Melanin nanoparticles as a promising tool for biomedical applications – a review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/66389 |
Resumo: | Melanin is a biopolymer of easy and cheap availability that can be found among the living organisms and excels for its biocompatibility and biodegradability properties, along with scavenging abilities, metal chelation and electronic conductance. This biomaterial can act as a nanocarrier or agent itself to be used in diverse biomedical applications, such as imaging, controlled drug release, bioengineering and bioelectronics, antioxidant applications and theranostics. In this review, the melanin source and structure, its physicochemical properties, melanin-like polymers as well as the differences among those will be elucidated. The focus will be the discussion of the current approaches that apply melanin nanoparticles (MNPs) and melanin-like nanoparticles (MLNPs) in the biomedical field, to which promising capabilities have been attributed, regarding optoelectronic, photoconductivity and photoacoustic. The use of these nanoparticles, in the last 10 years, in topics as drug delivery or theranostics will be detailed and the major achievements will be discussed. Overall, we anticipate that melanin can drive us toward a new paradigm in medical diagnostics and treatments, since applying melanin features possibly its use as a theranostics nanocarrier agent, not only for diagnostics, but also for photothermal therapy and controlled drug release through chemotherapy. |
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Melanin nanoparticles as a promising tool for biomedical applications – a reviewbioengineeringDrug Delivery SystemImagingmelaninNanoparticletheranosticsDioengineeringScience & TechnologyMelanin is a biopolymer of easy and cheap availability that can be found among the living organisms and excels for its biocompatibility and biodegradability properties, along with scavenging abilities, metal chelation and electronic conductance. This biomaterial can act as a nanocarrier or agent itself to be used in diverse biomedical applications, such as imaging, controlled drug release, bioengineering and bioelectronics, antioxidant applications and theranostics. In this review, the melanin source and structure, its physicochemical properties, melanin-like polymers as well as the differences among those will be elucidated. The focus will be the discussion of the current approaches that apply melanin nanoparticles (MNPs) and melanin-like nanoparticles (MLNPs) in the biomedical field, to which promising capabilities have been attributed, regarding optoelectronic, photoconductivity and photoacoustic. The use of these nanoparticles, in the last 10 years, in topics as drug delivery or theranostics will be detailed and the major achievements will be discussed. Overall, we anticipate that melanin can drive us toward a new paradigm in medical diagnostics and treatments, since applying melanin features possibly its use as a theranostics nanocarrier agent, not only for diagnostics, but also for photothermal therapy and controlled drug release through chemotherapy.VM Correlo would like to acknowledge FROnTHERA (NORTE-01–0145-FEDER-0000232) project. RRebelo would like to acknowledge BREAST-IT PTDC/BTM-ORG/28168/2017 project.Elsevier IncUniversidade do MinhoCaldas, M.Santos, A. C.Rebelo, R.Veiga, F.Reis, R. L.Correlo, V. M.2020-022020-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/66389engCaldas M., Santos A. C., Rebelo R., Veiga F., Reis R. L., Correlo V. M. Melanin nanoparticles as a promising tool for biomedical applications – a review, Acta Biomaterialia, Vol. 115, pp. 26-43, doi:10.1016/j.actbio.2020.01.044, 20201742-70611878-756810.1016/j.actbio.2020.01.04432014585https://doi.org/10.1016/j.actbio.2020.01.044info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:20:50Zoai:repositorium.sdum.uminho.pt:1822/66389Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:13:59.031585Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
title |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
spellingShingle |
Melanin nanoparticles as a promising tool for biomedical applications – a review Caldas, M. bioengineering Drug Delivery System Imaging melanin Nanoparticle theranostics Dioengineering Science & Technology |
title_short |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
title_full |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
title_fullStr |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
title_full_unstemmed |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
title_sort |
Melanin nanoparticles as a promising tool for biomedical applications – a review |
author |
Caldas, M. |
author_facet |
Caldas, M. Santos, A. C. Rebelo, R. Veiga, F. Reis, R. L. Correlo, V. M. |
author_role |
author |
author2 |
Santos, A. C. Rebelo, R. Veiga, F. Reis, R. L. Correlo, V. M. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Caldas, M. Santos, A. C. Rebelo, R. Veiga, F. Reis, R. L. Correlo, V. M. |
dc.subject.por.fl_str_mv |
bioengineering Drug Delivery System Imaging melanin Nanoparticle theranostics Dioengineering Science & Technology |
topic |
bioengineering Drug Delivery System Imaging melanin Nanoparticle theranostics Dioengineering Science & Technology |
description |
Melanin is a biopolymer of easy and cheap availability that can be found among the living organisms and excels for its biocompatibility and biodegradability properties, along with scavenging abilities, metal chelation and electronic conductance. This biomaterial can act as a nanocarrier or agent itself to be used in diverse biomedical applications, such as imaging, controlled drug release, bioengineering and bioelectronics, antioxidant applications and theranostics. In this review, the melanin source and structure, its physicochemical properties, melanin-like polymers as well as the differences among those will be elucidated. The focus will be the discussion of the current approaches that apply melanin nanoparticles (MNPs) and melanin-like nanoparticles (MLNPs) in the biomedical field, to which promising capabilities have been attributed, regarding optoelectronic, photoconductivity and photoacoustic. The use of these nanoparticles, in the last 10 years, in topics as drug delivery or theranostics will be detailed and the major achievements will be discussed. Overall, we anticipate that melanin can drive us toward a new paradigm in medical diagnostics and treatments, since applying melanin features possibly its use as a theranostics nanocarrier agent, not only for diagnostics, but also for photothermal therapy and controlled drug release through chemotherapy. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02 2020-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/66389 |
url |
https://hdl.handle.net/1822/66389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Caldas M., Santos A. C., Rebelo R., Veiga F., Reis R. L., Correlo V. M. Melanin nanoparticles as a promising tool for biomedical applications – a review, Acta Biomaterialia, Vol. 115, pp. 26-43, doi:10.1016/j.actbio.2020.01.044, 2020 1742-7061 1878-7568 10.1016/j.actbio.2020.01.044 32014585 https://doi.org/10.1016/j.actbio.2020.01.044 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Inc |
publisher.none.fl_str_mv |
Elsevier Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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