Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/20589 |
Resumo: | Since the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, butmanyhot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host–guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century. |
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Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a reviewCentral nervous systemDendrimersDrug delivery systemsRegenerative medicineTissue engineeringTheranosticsScience & TechnologySince the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, butmanyhot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host–guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century.The authors wish to acknowledge the funding provided by the Portuguese Foundation for Science and Technology (FCT) through the POCTI and FEDER programs, and FCT project (SMARTCARBO). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283) and European Union HIPPOCRATES STREP Project (NMP3-CT-2003-505758). Canon Foundation in Europe is also gratefully acknowledged.ElsevierUniversidade do MinhoOliveira, Joaquim M.Salgado, A. J.Sousa, NunoMano, J. F.Reis, R. L.2010-092010-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/20589eng0079-670010.1016/j.progpolymsci.2010.04.006http://www.sciencedirect.com/science/article/pii/S1359644604032763info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:30:12Zoai:repositorium.sdum.uminho.pt:1822/20589Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:25:20.083082Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
title |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
spellingShingle |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review Oliveira, Joaquim M. Central nervous system Dendrimers Drug delivery systems Regenerative medicine Tissue engineering Theranostics Science & Technology |
title_short |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
title_full |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
title_fullStr |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
title_full_unstemmed |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
title_sort |
Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies : a review |
author |
Oliveira, Joaquim M. |
author_facet |
Oliveira, Joaquim M. Salgado, A. J. Sousa, Nuno Mano, J. F. Reis, R. L. |
author_role |
author |
author2 |
Salgado, A. J. Sousa, Nuno Mano, J. F. Reis, R. L. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Oliveira, Joaquim M. Salgado, A. J. Sousa, Nuno Mano, J. F. Reis, R. L. |
dc.subject.por.fl_str_mv |
Central nervous system Dendrimers Drug delivery systems Regenerative medicine Tissue engineering Theranostics Science & Technology |
topic |
Central nervous system Dendrimers Drug delivery systems Regenerative medicine Tissue engineering Theranostics Science & Technology |
description |
Since the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, butmanyhot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host–guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-09 2010-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/20589 |
url |
http://hdl.handle.net/1822/20589 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0079-6700 10.1016/j.progpolymsci.2010.04.006 http://www.sciencedirect.com/science/article/pii/S1359644604032763 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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