Disconnection and reconnection: the morphological basis of (mal)adaptation to stress

Detalhes bibliográficos
Autor(a) principal: Sousa, Nuno
Data de Publicação: 2012
Outros Autores: Almeida, O. F. X.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/21091
Resumo: We would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions.
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spelling Disconnection and reconnection: the morphological basis of (mal)adaptation to stressStressCognitionEmotionPlasticityGlucocorticoidsScience & TechnologyWe would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions.Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive impairments. Research in both humans and animal models has begun to identify morphological correlates of these functional changes. These include dendritic and synaptic reorganization, glial remodeling, and altered cell fate in cortical and subcortical structures. The emerging view is that stress induces a disconnection syndrome’ whereby the transmission and integration of information that are critical for orchestrating appropriate physiological and behavioral responses are perturbed. High-resolution spatiotemporal mapping of the complete neural circuitry and identification of the cellular processes impacted by stress will help to advance discovery of strategies to reduce or reverse the burden of stress-related neuropsychiatric disorders.Work in our laboratories was supported by the German Academic Exchange Service - Acções Luso-Alemãs, Fundação para a Ciência e Tecnologia (PTDC/SAUNSC/ 111814/2009), and European Union FP7 (SwitchBox Project, Contract 259772; Neuroendocrine Immune Networks in Ageing Scientific Network, Contract 238665).ElsevierUniversidade do MinhoSousa, NunoAlmeida, O. F. X.2012-11-302012-11-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/21091eng0166-223610.1016/j.tins.2012.08.00623000140http://www.sciencedirect.com/science/article/pii/S0166223612001543info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:58:00Zoai:repositorium.sdum.uminho.pt:1822/21091Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:41.769743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
title Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
spellingShingle Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
Sousa, Nuno
Stress
Cognition
Emotion
Plasticity
Glucocorticoids
Science & Technology
title_short Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
title_full Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
title_fullStr Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
title_full_unstemmed Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
title_sort Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
author Sousa, Nuno
author_facet Sousa, Nuno
Almeida, O. F. X.
author_role author
author2 Almeida, O. F. X.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Sousa, Nuno
Almeida, O. F. X.
dc.subject.por.fl_str_mv Stress
Cognition
Emotion
Plasticity
Glucocorticoids
Science & Technology
topic Stress
Cognition
Emotion
Plasticity
Glucocorticoids
Science & Technology
description We would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions.
publishDate 2012
dc.date.none.fl_str_mv 2012-11-30
2012-11-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/21091
url http://hdl.handle.net/1822/21091
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0166-2236
10.1016/j.tins.2012.08.006
23000140
http://www.sciencedirect.com/science/article/pii/S0166223612001543
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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