Disconnection and reconnection: the morphological basis of (mal)adaptation to stress
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/21091 |
Resumo: | We would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions. |
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Disconnection and reconnection: the morphological basis of (mal)adaptation to stressStressCognitionEmotionPlasticityGlucocorticoidsScience & TechnologyWe would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions.Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive impairments. Research in both humans and animal models has begun to identify morphological correlates of these functional changes. These include dendritic and synaptic reorganization, glial remodeling, and altered cell fate in cortical and subcortical structures. The emerging view is that stress induces a disconnection syndrome’ whereby the transmission and integration of information that are critical for orchestrating appropriate physiological and behavioral responses are perturbed. High-resolution spatiotemporal mapping of the complete neural circuitry and identification of the cellular processes impacted by stress will help to advance discovery of strategies to reduce or reverse the burden of stress-related neuropsychiatric disorders.Work in our laboratories was supported by the German Academic Exchange Service - Acções Luso-Alemãs, Fundação para a Ciência e Tecnologia (PTDC/SAUNSC/ 111814/2009), and European Union FP7 (SwitchBox Project, Contract 259772; Neuroendocrine Immune Networks in Ageing Scientific Network, Contract 238665).ElsevierUniversidade do MinhoSousa, NunoAlmeida, O. F. X.2012-11-302012-11-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/21091eng0166-223610.1016/j.tins.2012.08.00623000140http://www.sciencedirect.com/science/article/pii/S0166223612001543info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:58:00Zoai:repositorium.sdum.uminho.pt:1822/21091Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:41.769743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
title |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
spellingShingle |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress Sousa, Nuno Stress Cognition Emotion Plasticity Glucocorticoids Science & Technology |
title_short |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
title_full |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
title_fullStr |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
title_full_unstemmed |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
title_sort |
Disconnection and reconnection: the morphological basis of (mal)adaptation to stress |
author |
Sousa, Nuno |
author_facet |
Sousa, Nuno Almeida, O. F. X. |
author_role |
author |
author2 |
Almeida, O. F. X. |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sousa, Nuno Almeida, O. F. X. |
dc.subject.por.fl_str_mv |
Stress Cognition Emotion Plasticity Glucocorticoids Science & Technology |
topic |
Stress Cognition Emotion Plasticity Glucocorticoids Science & Technology |
description |
We would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11-30 2012-11-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/21091 |
url |
http://hdl.handle.net/1822/21091 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0166-2236 10.1016/j.tins.2012.08.006 23000140 http://www.sciencedirect.com/science/article/pii/S0166223612001543 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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