Plexins function in epithelial repair in both Drosophila and zebrafish
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1038/ncomms12282 |
Resumo: | In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa. |
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Plexins function in epithelial repair in both Drosophila and zebrafishBiochemistry, Genetics and Molecular Biology(all)Chemistry(all)Physics and Astronomy(all)In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNYoo, Sa KanPascoe, Heath G.Pereira, TelmoKondo, ShuJacinto, AntonioZhang, XuewuHariharan, Iswar K.2017-12-11T23:06:38Z2016-07-252016-07-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttps://doi.org/10.1038/ncomms12282eng2041-1723PURE: 1172056http://www.scopus.com/inward/record.url?scp=84979516632&partnerID=8YFLogxKhttps://doi.org/10.1038/ncomms12282info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:13:59Zoai:run.unl.pt:10362/26616Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:31.035405Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Plexins function in epithelial repair in both Drosophila and zebrafish |
title |
Plexins function in epithelial repair in both Drosophila and zebrafish |
spellingShingle |
Plexins function in epithelial repair in both Drosophila and zebrafish Yoo, Sa Kan Biochemistry, Genetics and Molecular Biology(all) Chemistry(all) Physics and Astronomy(all) |
title_short |
Plexins function in epithelial repair in both Drosophila and zebrafish |
title_full |
Plexins function in epithelial repair in both Drosophila and zebrafish |
title_fullStr |
Plexins function in epithelial repair in both Drosophila and zebrafish |
title_full_unstemmed |
Plexins function in epithelial repair in both Drosophila and zebrafish |
title_sort |
Plexins function in epithelial repair in both Drosophila and zebrafish |
author |
Yoo, Sa Kan |
author_facet |
Yoo, Sa Kan Pascoe, Heath G. Pereira, Telmo Kondo, Shu Jacinto, Antonio Zhang, Xuewu Hariharan, Iswar K. |
author_role |
author |
author2 |
Pascoe, Heath G. Pereira, Telmo Kondo, Shu Jacinto, Antonio Zhang, Xuewu Hariharan, Iswar K. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Yoo, Sa Kan Pascoe, Heath G. Pereira, Telmo Kondo, Shu Jacinto, Antonio Zhang, Xuewu Hariharan, Iswar K. |
dc.subject.por.fl_str_mv |
Biochemistry, Genetics and Molecular Biology(all) Chemistry(all) Physics and Astronomy(all) |
topic |
Biochemistry, Genetics and Molecular Biology(all) Chemistry(all) Physics and Astronomy(all) |
description |
In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-25 2016-07-25T00:00:00Z 2017-12-11T23:06:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1038/ncomms12282 |
url |
https://doi.org/10.1038/ncomms12282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2041-1723 PURE: 1172056 http://www.scopus.com/inward/record.url?scp=84979516632&partnerID=8YFLogxK https://doi.org/10.1038/ncomms12282 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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