Plexins function in epithelial repair in both Drosophila and zebrafish

Detalhes bibliográficos
Autor(a) principal: Yoo, Sa Kan
Data de Publicação: 2016
Outros Autores: Pascoe, Heath G., Pereira, Telmo, Kondo, Shu, Jacinto, Antonio, Zhang, Xuewu, Hariharan, Iswar K.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1038/ncomms12282
Resumo: In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa.
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spelling Plexins function in epithelial repair in both Drosophila and zebrafishBiochemistry, Genetics and Molecular Biology(all)Chemistry(all)Physics and Astronomy(all)In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNYoo, Sa KanPascoe, Heath G.Pereira, TelmoKondo, ShuJacinto, AntonioZhang, XuewuHariharan, Iswar K.2017-12-11T23:06:38Z2016-07-252016-07-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttps://doi.org/10.1038/ncomms12282eng2041-1723PURE: 1172056http://www.scopus.com/inward/record.url?scp=84979516632&partnerID=8YFLogxKhttps://doi.org/10.1038/ncomms12282info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:13:59Zoai:run.unl.pt:10362/26616Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:31.035405Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Plexins function in epithelial repair in both Drosophila and zebrafish
title Plexins function in epithelial repair in both Drosophila and zebrafish
spellingShingle Plexins function in epithelial repair in both Drosophila and zebrafish
Yoo, Sa Kan
Biochemistry, Genetics and Molecular Biology(all)
Chemistry(all)
Physics and Astronomy(all)
title_short Plexins function in epithelial repair in both Drosophila and zebrafish
title_full Plexins function in epithelial repair in both Drosophila and zebrafish
title_fullStr Plexins function in epithelial repair in both Drosophila and zebrafish
title_full_unstemmed Plexins function in epithelial repair in both Drosophila and zebrafish
title_sort Plexins function in epithelial repair in both Drosophila and zebrafish
author Yoo, Sa Kan
author_facet Yoo, Sa Kan
Pascoe, Heath G.
Pereira, Telmo
Kondo, Shu
Jacinto, Antonio
Zhang, Xuewu
Hariharan, Iswar K.
author_role author
author2 Pascoe, Heath G.
Pereira, Telmo
Kondo, Shu
Jacinto, Antonio
Zhang, Xuewu
Hariharan, Iswar K.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Yoo, Sa Kan
Pascoe, Heath G.
Pereira, Telmo
Kondo, Shu
Jacinto, Antonio
Zhang, Xuewu
Hariharan, Iswar K.
dc.subject.por.fl_str_mv Biochemistry, Genetics and Molecular Biology(all)
Chemistry(all)
Physics and Astronomy(all)
topic Biochemistry, Genetics and Molecular Biology(all)
Chemistry(all)
Physics and Astronomy(all)
description In most multicellular organisms, homeostasis is contingent upon maintaining epithelial integrity. When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair are immediately activated. However, many of the mechanisms that repair damaged epithelia remain poorly characterized. Here we describe a role for Plexin A (PlexA), a protein with particularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Drosophila. Semaphorins, which are PlexA ligands, also regulate tissue repair. We show that Drosophila PlexA has GAP activity for the Rap1 GTPase, which is known to regulate the stability of adherens junctions. Our observations suggest that the inhibition of Rap1 activity by PlexA in damaged Drosophila epithelia allows epithelial remodelling, thus facilitating wound repair. We also demonstrate a role for Plexin A1, a zebrafish orthologue of Drosophila PlexA, in epithelial repair in zebrafish tail fins. Thus, plexins function in epithelial wound healing in diverse taxa.
publishDate 2016
dc.date.none.fl_str_mv 2016-07-25
2016-07-25T00:00:00Z
2017-12-11T23:06:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://doi.org/10.1038/ncomms12282
url https://doi.org/10.1038/ncomms12282
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2041-1723
PURE: 1172056
http://www.scopus.com/inward/record.url?scp=84979516632&partnerID=8YFLogxK
https://doi.org/10.1038/ncomms12282
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