Low-energy electrons transform the nimorazole molecule into a radiosensitiser

Detalhes bibliográficos
Autor(a) principal: Meißner, Rebecca
Data de Publicação: 2019
Outros Autores: Kočišek, Jaroslav, Feketeová, Linda, Fedor, Juraj, Fárník, Michal, Limão-Vieira, Paulo, Illenberger, Eugen, Denifl, Stephan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/104982
Resumo: This work was supported by FWF, Vienna (P30332). R.M. and P.L.V. acknowledge the Portuguese National Funding Agency FCT-MCTES through PD/BD/114452/2016 and research grants UID/FIS/00068/2019 (CEFITEC) and PTDC/FIS-AQM/31281/2017. This work was also supported by Radiation Biology and Biophysics Doctoral Training Programme (RaBBiT, PD/00193/2010); UID/Multi/04378/2019 (UCIBIO). J.K. acknowledges the support by the Czech Science Foundation Grant 19-01159S. L.F. is grateful to the LABEX Lyon Institute of Origins (ANR-10-LABX-0066) of the Universite de Lyon for its financial support within the program "Investissements d'Avenir" (ANR-11-IDEX-0007) of the French government operated by the National Research Agency (ANR).
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spelling Low-energy electrons transform the nimorazole molecule into a radiosensitiserChemistry(all)Biochemistry, Genetics and Molecular Biology(all)Physics and Astronomy(all)This work was supported by FWF, Vienna (P30332). R.M. and P.L.V. acknowledge the Portuguese National Funding Agency FCT-MCTES through PD/BD/114452/2016 and research grants UID/FIS/00068/2019 (CEFITEC) and PTDC/FIS-AQM/31281/2017. This work was also supported by Radiation Biology and Biophysics Doctoral Training Programme (RaBBiT, PD/00193/2010); UID/Multi/04378/2019 (UCIBIO). J.K. acknowledges the support by the Czech Science Foundation Grant 19-01159S. L.F. is grateful to the LABEX Lyon Institute of Origins (ANR-10-LABX-0066) of the Universite de Lyon for its financial support within the program "Investissements d'Avenir" (ANR-11-IDEX-0007) of the French government operated by the National Research Agency (ANR).While matter is irradiated with highly-energetic particles, it may become chemically modified. Thereby, the reactions of free low-energy electrons (LEEs) formed as secondary particles play an important role. It is unknown to what degree and by which mechanism LEEs contribute to the action of electron-affinic radiosensitisers applied in radiotherapy of hypoxic tumours. Here we show that LEEs effectively cause the reduction of the radiosensitiser nimorazole via associative electron attachment with the cross-section exceeding most of known molecules. This supports the hypothesis that nimorazole is selectively cytotoxic to tumour cells due to reduction of the molecule as prerequisite for accumulation in the cell. In contrast, dissociative electron attachment, commonly believed to be the source of chemical activity of LEEs, represents only a minor reaction channel which is further suppressed upon hydration. Our results show that LEEs may strongly contribute to the radiosensitising effect of nimorazole via associative electron attachment.DF – Departamento de FísicaCeFITec – Centro de Física e Investigação TecnológicaRUNMeißner, RebeccaKočišek, JaroslavFeketeová, LindaFedor, JurajFárník, MichalLimão-Vieira, PauloIllenberger, EugenDenifl, Stephan2020-09-30T22:22:49Z2019-12-012019-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/104982eng2041-1723PURE: 18783922https://doi.org/10.1038/s41467-019-10340-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:50:26Zoai:run.unl.pt:10362/104982Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:22.833972Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title Low-energy electrons transform the nimorazole molecule into a radiosensitiser
spellingShingle Low-energy electrons transform the nimorazole molecule into a radiosensitiser
Meißner, Rebecca
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
title_short Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_full Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_fullStr Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_full_unstemmed Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_sort Low-energy electrons transform the nimorazole molecule into a radiosensitiser
author Meißner, Rebecca
author_facet Meißner, Rebecca
Kočišek, Jaroslav
Feketeová, Linda
Fedor, Juraj
Fárník, Michal
Limão-Vieira, Paulo
Illenberger, Eugen
Denifl, Stephan
author_role author
author2 Kočišek, Jaroslav
Feketeová, Linda
Fedor, Juraj
Fárník, Michal
Limão-Vieira, Paulo
Illenberger, Eugen
Denifl, Stephan
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DF – Departamento de Física
CeFITec – Centro de Física e Investigação Tecnológica
RUN
dc.contributor.author.fl_str_mv Meißner, Rebecca
Kočišek, Jaroslav
Feketeová, Linda
Fedor, Juraj
Fárník, Michal
Limão-Vieira, Paulo
Illenberger, Eugen
Denifl, Stephan
dc.subject.por.fl_str_mv Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
topic Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
description This work was supported by FWF, Vienna (P30332). R.M. and P.L.V. acknowledge the Portuguese National Funding Agency FCT-MCTES through PD/BD/114452/2016 and research grants UID/FIS/00068/2019 (CEFITEC) and PTDC/FIS-AQM/31281/2017. This work was also supported by Radiation Biology and Biophysics Doctoral Training Programme (RaBBiT, PD/00193/2010); UID/Multi/04378/2019 (UCIBIO). J.K. acknowledges the support by the Czech Science Foundation Grant 19-01159S. L.F. is grateful to the LABEX Lyon Institute of Origins (ANR-10-LABX-0066) of the Universite de Lyon for its financial support within the program "Investissements d'Avenir" (ANR-11-IDEX-0007) of the French government operated by the National Research Agency (ANR).
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
2019-12-01T00:00:00Z
2020-09-30T22:22:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/104982
url http://hdl.handle.net/10362/104982
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2041-1723
PURE: 18783922
https://doi.org/10.1038/s41467-019-10340-8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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