Signal transduction pathways regulating alternative splicing of tumour-related RAC1b

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Vânia
Data de Publicação: 2017
Outros Autores: Matos, Paulo, Henriques, Andreia, Pereira, Joana, Jordan, Peter
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5395
Resumo: The expression of most genes in the human genome can yield >1 transcript through the process of alternative splicing of pre-messenger RNA. Alternatively spliced transcripts significantly increase the complexity of human gene products because they either influence transcript degradation levels or encode functional protein variants that differ in specific domains. Even with cutting-edge transcriptomic approaches, it has been extremely challenging to understand or predict the complex splicing patterns observed in tissues or in diseases such as cancer; therefore, a better understanding of how cells are able to regulate alternative splicing is required.
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spelling Signal transduction pathways regulating alternative splicing of tumour-related RAC1bSignalling PathwaysAlternative SplicingRAC1bSplicing AlternativoVias de Transdução de Sinal e Patologias AssociadasCancro ColoretalThe expression of most genes in the human genome can yield >1 transcript through the process of alternative splicing of pre-messenger RNA. Alternatively spliced transcripts significantly increase the complexity of human gene products because they either influence transcript degradation levels or encode functional protein variants that differ in specific domains. Even with cutting-edge transcriptomic approaches, it has been extremely challenging to understand or predict the complex splicing patterns observed in tissues or in diseases such as cancer; therefore, a better understanding of how cells are able to regulate alternative splicing is required.This work was supported by the Fundação para a Ciência e Tecnologia through a centre grant (UID/MULTI/04046/2013) to BioISI, and by the Portuguese association Maratona da Saúde - Cancro 2014.European Medical JournalRepositório Científico do Instituto Nacional de SaúdeGonçalves, VâniaMatos, PauloHenriques, AndreiaPereira, JoanaJordan, Peter2018-03-13T15:31:19Z2017-102017-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5395engEMJ Oncol. 2017;51[1]:45-46. Abstract review No. AR5ISSN-2054-619Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:43Zoai:repositorio.insa.pt:10400.18/5395Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:54.403660Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
title Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
spellingShingle Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
Gonçalves, Vânia
Signalling Pathways
Alternative Splicing
RAC1b
Splicing Alternativo
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
title_short Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
title_full Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
title_fullStr Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
title_full_unstemmed Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
title_sort Signal transduction pathways regulating alternative splicing of tumour-related RAC1b
author Gonçalves, Vânia
author_facet Gonçalves, Vânia
Matos, Paulo
Henriques, Andreia
Pereira, Joana
Jordan, Peter
author_role author
author2 Matos, Paulo
Henriques, Andreia
Pereira, Joana
Jordan, Peter
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Gonçalves, Vânia
Matos, Paulo
Henriques, Andreia
Pereira, Joana
Jordan, Peter
dc.subject.por.fl_str_mv Signalling Pathways
Alternative Splicing
RAC1b
Splicing Alternativo
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
topic Signalling Pathways
Alternative Splicing
RAC1b
Splicing Alternativo
Vias de Transdução de Sinal e Patologias Associadas
Cancro Coloretal
description The expression of most genes in the human genome can yield >1 transcript through the process of alternative splicing of pre-messenger RNA. Alternatively spliced transcripts significantly increase the complexity of human gene products because they either influence transcript degradation levels or encode functional protein variants that differ in specific domains. Even with cutting-edge transcriptomic approaches, it has been extremely challenging to understand or predict the complex splicing patterns observed in tissues or in diseases such as cancer; therefore, a better understanding of how cells are able to regulate alternative splicing is required.
publishDate 2017
dc.date.none.fl_str_mv 2017-10
2017-10-01T00:00:00Z
2018-03-13T15:31:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5395
url http://hdl.handle.net/10400.18/5395
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv EMJ Oncol. 2017;51[1]:45-46. Abstract review No. AR5
ISSN-2054-619X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Medical Journal
publisher.none.fl_str_mv European Medical Journal
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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