Anti-Aspergillus fumigatus IgG in patients with bronchiectasis and its relationship with clinical outcome

• Autor(a) principal: Rodrigues Trápaga, Mariana
• Data de Publicação: 2022
• Outros Autores: Rodrigues Poester, Vanice, Sanchotene, Karine Ortiz, Martins Melo, Aryse, Benelli, Jéssica Louise, Basso, Rossana Patricia, Klafke, Gabriel Baracy, Fernandes Ramos, Daniela, Veríssimo, Cristina, Sabino, Raquel, Stevens, David A., Xavier, Melissa Orzechowski
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.18/8513
• topic: Aspergillosis; Aspergillus IgG; Fungal Disease; Immunodifusion; ELISA; Infecções Sistémicas e Zoonoses

Aspergillosis is a mycosis, most commonly afecting the airways. This mycosis can worsen the clinical condition of patients with concurrent lung diseases. We assayed for the presence of serum anti-A. fumigatus IgG in bronchiectasis patients from a tertiary hospital in south Brazil and evaluated the relationship with clinical outcome. Thirty-one patients with bronchiec tasis, without cystic fbrosis, were included. Clinical and epidemiological data were collected from all participants. Positive serological tests were detected in 13% (4/31) of the patients. The mortality rate for the year following the assay was, in the seropositive group, 75% (3/4), whereas in the seronegative group, 15% (4/27). An illustrative case is also shown and discussed. Our study highlights the diagnostic challenge and the possible impact of Aspergillus infection on these patients, indicating the necessity of more and larger investigations in the feld