Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/109079 https://doi.org/10.1186/s12864-014-1201-x |
Resumo: | Background: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. Results: In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. Conclusions: The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated “later” events of (South) East Asian origin pinpoints a highly dynamic migratory phase. |
id |
RCAP_0768850f50c391986ec3dde3bd50bb2e |
---|---|
oai_identifier_str |
oai:estudogeral.uc.pt:10316/109079 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversityEast Timor (Timor-Leste)Island Southeast AsiaMitochondrial DNAmtDNA haplogroup PHuman migrationFirst settlersPopulation geneticsForensic mtDNA analysisNext generation sequencingIon Torrent PGMAsian PeopleAustraliaChromosomes, Human, YDNA, MitochondrialFemaleGeographyHaplotypesHistory, AncientHuman MigrationHumansMaleMolecular Sequence DataTimor-LestePhylogenyBackground: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. Results: In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. Conclusions: The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated “later” events of (South) East Asian origin pinpoints a highly dynamic migratory phase.Springer Nature2015-02-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109079http://hdl.handle.net/10316/109079https://doi.org/10.1186/s12864-014-1201-xeng1471-2164Gomes, Sibylle M.Bodner, MartinSouto, LuísZimmermann, BettinaHuber, GabrielaStrobl, ChristinaRöck, Alexander W.Achilli, AlessandroOlivieri, AnnaTorroni, AntonioCorte Real, FranciscoParson, Waltherinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-27T08:02:51Zoai:estudogeral.uc.pt:10316/109079Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:17.412015Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
title |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
spellingShingle |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity Gomes, Sibylle M. East Timor (Timor-Leste) Island Southeast Asia Mitochondrial DNA mtDNA haplogroup P Human migration First settlers Population genetics Forensic mtDNA analysis Next generation sequencing Ion Torrent PGM Asian People Australia Chromosomes, Human, Y DNA, Mitochondrial Female Geography Haplotypes History, Ancient Human Migration Humans Male Molecular Sequence Data Timor-Leste Phylogeny |
title_short |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
title_full |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
title_fullStr |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
title_full_unstemmed |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
title_sort |
Human settlement history between Sunda and Sahul: a focus on East Timor (Timor-Leste) and the Pleistocenic mtDNA diversity |
author |
Gomes, Sibylle M. |
author_facet |
Gomes, Sibylle M. Bodner, Martin Souto, Luís Zimmermann, Bettina Huber, Gabriela Strobl, Christina Röck, Alexander W. Achilli, Alessandro Olivieri, Anna Torroni, Antonio Corte Real, Francisco Parson, Walther |
author_role |
author |
author2 |
Bodner, Martin Souto, Luís Zimmermann, Bettina Huber, Gabriela Strobl, Christina Röck, Alexander W. Achilli, Alessandro Olivieri, Anna Torroni, Antonio Corte Real, Francisco Parson, Walther |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Sibylle M. Bodner, Martin Souto, Luís Zimmermann, Bettina Huber, Gabriela Strobl, Christina Röck, Alexander W. Achilli, Alessandro Olivieri, Anna Torroni, Antonio Corte Real, Francisco Parson, Walther |
dc.subject.por.fl_str_mv |
East Timor (Timor-Leste) Island Southeast Asia Mitochondrial DNA mtDNA haplogroup P Human migration First settlers Population genetics Forensic mtDNA analysis Next generation sequencing Ion Torrent PGM Asian People Australia Chromosomes, Human, Y DNA, Mitochondrial Female Geography Haplotypes History, Ancient Human Migration Humans Male Molecular Sequence Data Timor-Leste Phylogeny |
topic |
East Timor (Timor-Leste) Island Southeast Asia Mitochondrial DNA mtDNA haplogroup P Human migration First settlers Population genetics Forensic mtDNA analysis Next generation sequencing Ion Torrent PGM Asian People Australia Chromosomes, Human, Y DNA, Mitochondrial Female Geography Haplotypes History, Ancient Human Migration Humans Male Molecular Sequence Data Timor-Leste Phylogeny |
description |
Background: Distinct, partly competing, “waves” have been proposed to explain human migration in(to) today’s Island Southeast Asia and Australia based on genetic (and other) evidence. The paucity of high quality and high resolution data has impeded insights so far. In this study, one of the first in a forensic environment, we used the Ion Torrent Personal Genome Machine (PGM) for generating complete mitogenome sequences via stand-alone massively parallel sequencing and describe a standard data validation practice. Results: In this first representative investigation on the mitochondrial DNA (mtDNA) variation of East Timor (Timor-Leste) population including >300 individuals, we put special emphasis on the reconstruction of the initial settlement, in particular on the previously poorly resolved haplogroup P1, an indigenous lineage of the Southwest Pacific region. Our results suggest a colonization of southern Sahul (Australia) >37 kya, limited subsequent exchange, and a parallel incubation of initial settlers in northern Sahul (New Guinea) followed by westward migrations <28 kya. Conclusions: The temporal proximity and possible coincidence of these latter dispersals, which encompassed autochthonous haplogroups, with the postulated “later” events of (South) East Asian origin pinpoints a highly dynamic migratory phase. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/109079 http://hdl.handle.net/10316/109079 https://doi.org/10.1186/s12864-014-1201-x |
url |
http://hdl.handle.net/10316/109079 https://doi.org/10.1186/s12864-014-1201-x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134135759929344 |