Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations

Detalhes bibliográficos
Autor(a) principal: Susano, Patrícia
Data de Publicação: 2022
Outros Autores: Silva, Joana, Alves, Celso, Martins, Alice, Pinteus, Susete, Gaspar, Helena, Goettert, Márcia Inês, Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8755
Resumo: This work was funded by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects granted to the MARE—Marine and Environmental Sciences Centre (UIDP/04292/2020; UIDB/04292/2020), BioISI—BioSystems and Integrative Sciences Institute (UIDP/Multi/04046/2020; UIDB/04046/2020), and Associate Laboratory ARNET (LA/P/0069/2020). FCT also supported this study through the CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (PO-CI-01-0145-FEDER-029250). This work was also supported by the FCT and CAPES cooperation agreement through project MArTics (FCT/DRI/CAPES 2019.00277.CBM). It was also funded by the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC.
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spelling Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulationsBioactive compoundsBrown macroalgaeDermatological potentialOxidative stressAnti-inflammatory activityThis work was funded by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects granted to the MARE—Marine and Environmental Sciences Centre (UIDP/04292/2020; UIDB/04292/2020), BioISI—BioSystems and Integrative Sciences Institute (UIDP/Multi/04046/2020; UIDB/04046/2020), and Associate Laboratory ARNET (LA/P/0069/2020). FCT also supported this study through the CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (PO-CI-01-0145-FEDER-029250). This work was also supported by the FCT and CAPES cooperation agreement through project MArTics (FCT/DRI/CAPES 2019.00277.CBM). It was also funded by the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC.The growing knowledge about the harmful effects caused by some synthetic ingredients present in skincare products has led to an extensive search for natural bioactives. Thus, this study aimed to investigate the dermatological potential of five fractions (F1–F5), obtained by a sequential extraction procedure, from the brown seaweed Saccorhiza polyschides. The antioxidant (DPPH, FRAP, ORAC and TPC), anti-enzymatic (collagenase, elastase, hyaluronidase and tyrosinase), antimicrobial (Staphylococcus epidermidis, Cutibacterium acnes and Malassezia furfur), anti-inflammatory (nitric oxide, tumor necrosis factor-α, interleukin-6 and interleukin-10) and photoprotective (reactive oxygen species) properties of all fractions were evaluated. The ethyl acetate fraction (F3) displayed the highest antioxidant and photoprotective capacity, reducing ROS levels in UVA/B-exposed 3T3 fibroblasts, and the highest anti-enzymatic capacity against tyrosinase (IC50 value: 89.1 µg/mL). The solid water-insoluble fraction (F5) revealed the greatest antimicrobial activity against C. acnes growth (IC50 value: 12.4 µg/mL). Furthermore, all fractions demonstrated anti-inflammatory potential, reducing TNF-α and IL-6 levels in RAW 264.7 macrophages induced with lipopolysaccharides. Chemical analysis of the S. polyschides fractions by NMR revealed the presence of different classes of compounds, including lipids, polyphenols and sugars. The results highlight the potential of S. polyschides to be incorporated into new nature-based skincare products.MDPIIC-OnlineSusano, PatríciaSilva, JoanaAlves, CelsoMartins, AlicePinteus, SuseteGaspar, HelenaGoettert, Márcia InêsPedrosa, Rui2023-09-04T13:16:54Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8755engSusano, P.; Silva, J.; Alves, C.; Martins, A.; Pinteus, S.; Gaspar, H.; Goettert, M.I.; Pedrosa, R. Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations. Molecules 2022, 27, 6496. https:// doi.org/10.3390/molecules271964961420-304910.3390/molecules27196496info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:58:06Zoai:iconline.ipleiria.pt:10400.8/8755Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:24.723437Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
title Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
spellingShingle Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
Susano, Patrícia
Bioactive compounds
Brown macroalgae
Dermatological potential
Oxidative stress
Anti-inflammatory activity
title_short Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
title_full Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
title_fullStr Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
title_full_unstemmed Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
title_sort Saccorhiza polyschides: A source of natural active ingredients for greener skincare formulations
author Susano, Patrícia
author_facet Susano, Patrícia
Silva, Joana
Alves, Celso
Martins, Alice
Pinteus, Susete
Gaspar, Helena
Goettert, Márcia Inês
Pedrosa, Rui
author_role author
author2 Silva, Joana
Alves, Celso
Martins, Alice
Pinteus, Susete
Gaspar, Helena
Goettert, Márcia Inês
Pedrosa, Rui
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Susano, Patrícia
Silva, Joana
Alves, Celso
Martins, Alice
Pinteus, Susete
Gaspar, Helena
Goettert, Márcia Inês
Pedrosa, Rui
dc.subject.por.fl_str_mv Bioactive compounds
Brown macroalgae
Dermatological potential
Oxidative stress
Anti-inflammatory activity
topic Bioactive compounds
Brown macroalgae
Dermatological potential
Oxidative stress
Anti-inflammatory activity
description This work was funded by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects granted to the MARE—Marine and Environmental Sciences Centre (UIDP/04292/2020; UIDB/04292/2020), BioISI—BioSystems and Integrative Sciences Institute (UIDP/Multi/04046/2020; UIDB/04046/2020), and Associate Laboratory ARNET (LA/P/0069/2020). FCT also supported this study through the CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-financed by COMPETE (PO-CI-01-0145-FEDER-029250). This work was also supported by the FCT and CAPES cooperation agreement through project MArTics (FCT/DRI/CAPES 2019.00277.CBM). It was also funded by the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-09-04T13:16:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8755
url http://hdl.handle.net/10400.8/8755
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Susano, P.; Silva, J.; Alves, C.; Martins, A.; Pinteus, S.; Gaspar, H.; Goettert, M.I.; Pedrosa, R. Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations. Molecules 2022, 27, 6496. https:// doi.org/10.3390/molecules27196496
1420-3049
10.3390/molecules27196496
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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