Cracking the Toll-like receptor code in fungal infections

Detalhes bibliográficos
Autor(a) principal: Cunha, Cristina
Data de Publicação: 2010
Outros Autores: Romani, Luigina, Carvalho, Agostinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/29617
Resumo: Innate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors. In addition to the role in inducing protective immune responses, Toll-like receptor engagement may paradoxically favor fungal infections, by inducing inflammatory pathology and impairing antifungal immunity. Although the dissection of complex genetic traits modulating susceptibility to fungal infections is complex, the contribution of host genetics may hold the key to elucidating new risk factors for these severe, often fatal diseases. Understanding host-pathogen interactions at the innate immune interface will eventually lead to the development of new therapeutics and genetic markers in fungal infections.
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spelling Cracking the Toll-like receptor code in fungal infectionsFungal infectionsGenetic susceptibilityInflammationInnate immunityToll-like receptorsScience & TechnologyInnate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors. In addition to the role in inducing protective immune responses, Toll-like receptor engagement may paradoxically favor fungal infections, by inducing inflammatory pathology and impairing antifungal immunity. Although the dissection of complex genetic traits modulating susceptibility to fungal infections is complex, the contribution of host genetics may hold the key to elucidating new risk factors for these severe, often fatal diseases. Understanding host-pathogen interactions at the innate immune interface will eventually lead to the development of new therapeutics and genetic markers in fungal infections.This work was supported by the Specific Targeted Research Projects SYBARIS (FP7-HEALTH-2009), contract number 242220, and by the Italian Project PRIN 2007KLCKP8_004. Cristina Cunha and Agostinho Carvalho were financially supported by fellowships from Fundacao para a Ciencia e Tecnologia, Portugal (contracts SFRH/BD/65962/2009 and SFRH/BPD/46292/2008, respectively). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Informa HealthcareUniversidade do MinhoCunha, CristinaRomani, LuiginaCarvalho, Agostinho2010-102010-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29617eng1478-721010.1586/eri.10.9320954879http://www.expert-reviews.com/doi/abs/10.1586/eri.10.93info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:51Zoai:repositorium.sdum.uminho.pt:1822/29617Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:48:27.021895Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cracking the Toll-like receptor code in fungal infections
title Cracking the Toll-like receptor code in fungal infections
spellingShingle Cracking the Toll-like receptor code in fungal infections
Cunha, Cristina
Fungal infections
Genetic susceptibility
Inflammation
Innate immunity
Toll-like receptors
Science & Technology
title_short Cracking the Toll-like receptor code in fungal infections
title_full Cracking the Toll-like receptor code in fungal infections
title_fullStr Cracking the Toll-like receptor code in fungal infections
title_full_unstemmed Cracking the Toll-like receptor code in fungal infections
title_sort Cracking the Toll-like receptor code in fungal infections
author Cunha, Cristina
author_facet Cunha, Cristina
Romani, Luigina
Carvalho, Agostinho
author_role author
author2 Romani, Luigina
Carvalho, Agostinho
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cunha, Cristina
Romani, Luigina
Carvalho, Agostinho
dc.subject.por.fl_str_mv Fungal infections
Genetic susceptibility
Inflammation
Innate immunity
Toll-like receptors
Science & Technology
topic Fungal infections
Genetic susceptibility
Inflammation
Innate immunity
Toll-like receptors
Science & Technology
description Innate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors. In addition to the role in inducing protective immune responses, Toll-like receptor engagement may paradoxically favor fungal infections, by inducing inflammatory pathology and impairing antifungal immunity. Although the dissection of complex genetic traits modulating susceptibility to fungal infections is complex, the contribution of host genetics may hold the key to elucidating new risk factors for these severe, often fatal diseases. Understanding host-pathogen interactions at the innate immune interface will eventually lead to the development of new therapeutics and genetic markers in fungal infections.
publishDate 2010
dc.date.none.fl_str_mv 2010-10
2010-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/29617
url http://hdl.handle.net/1822/29617
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1478-7210
10.1586/eri.10.93
20954879
http://www.expert-reviews.com/doi/abs/10.1586/eri.10.93
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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