Stress transiently affects Pavlovian-to-instrumental transfer

Detalhes bibliográficos
Autor(a) principal: Morgado, Pedro
Data de Publicação: 2012
Outros Autores: Silva, Miguel, Sousa, Nuno, Cerqueira, João José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/19900
Resumo: Stress has a strong impact in the brain, impairing decision-making processes as a result of changes in circuits involving the prefrontal and orbitofrontal cortices and the striatum. Given that these same circuits are key for action control and outcome encoding, we hypothesized that adaptive responses to which these are essential functions, could also be targeted by stress. To test this hypothesis we herein assessed the impact of chronic stress in a Pavlovian-to-instrumental transfer (PIT) paradigm, a model of an adaptive response in which a previously conditioned cue biases an instrumental goal-directed action. Data reveals that rats submitted to chronic unpredictable stress did not display deficits in pavlovian conditioning nor on the learning of the instrumental task, but were impaired in PIT; importantly, after a stress-free period the PIT deficits were no longer observed. These results are relevant to understand how stress biases multiple incentive processes that contribute to instrumental performance.
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spelling Stress transiently affects Pavlovian-to-instrumental transferStressConditioningPavlovian-to-instrumental transferChoicesScience & TechnologyStress has a strong impact in the brain, impairing decision-making processes as a result of changes in circuits involving the prefrontal and orbitofrontal cortices and the striatum. Given that these same circuits are key for action control and outcome encoding, we hypothesized that adaptive responses to which these are essential functions, could also be targeted by stress. To test this hypothesis we herein assessed the impact of chronic stress in a Pavlovian-to-instrumental transfer (PIT) paradigm, a model of an adaptive response in which a previously conditioned cue biases an instrumental goal-directed action. Data reveals that rats submitted to chronic unpredictable stress did not display deficits in pavlovian conditioning nor on the learning of the instrumental task, but were impaired in PIT; importantly, after a stress-free period the PIT deficits were no longer observed. These results are relevant to understand how stress biases multiple incentive processes that contribute to instrumental performance.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/SINTD/60129/2009, PTDC/SAU-NSC/111814/2009 FEDERFEDER - Operational program for competitivity factors – COMPETEFrontiers MediaUniversidade do MinhoMorgado, PedroSilva, MiguelSousa, NunoCerqueira, João José2012-062012-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/19900eng1662-453X10.3389/fnins.2012.00093info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:41:30Zoai:repositorium.sdum.uminho.pt:1822/19900Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:38:29.909916Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Stress transiently affects Pavlovian-to-instrumental transfer
title Stress transiently affects Pavlovian-to-instrumental transfer
spellingShingle Stress transiently affects Pavlovian-to-instrumental transfer
Morgado, Pedro
Stress
Conditioning
Pavlovian-to-instrumental transfer
Choices
Science & Technology
title_short Stress transiently affects Pavlovian-to-instrumental transfer
title_full Stress transiently affects Pavlovian-to-instrumental transfer
title_fullStr Stress transiently affects Pavlovian-to-instrumental transfer
title_full_unstemmed Stress transiently affects Pavlovian-to-instrumental transfer
title_sort Stress transiently affects Pavlovian-to-instrumental transfer
author Morgado, Pedro
author_facet Morgado, Pedro
Silva, Miguel
Sousa, Nuno
Cerqueira, João José
author_role author
author2 Silva, Miguel
Sousa, Nuno
Cerqueira, João José
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Morgado, Pedro
Silva, Miguel
Sousa, Nuno
Cerqueira, João José
dc.subject.por.fl_str_mv Stress
Conditioning
Pavlovian-to-instrumental transfer
Choices
Science & Technology
topic Stress
Conditioning
Pavlovian-to-instrumental transfer
Choices
Science & Technology
description Stress has a strong impact in the brain, impairing decision-making processes as a result of changes in circuits involving the prefrontal and orbitofrontal cortices and the striatum. Given that these same circuits are key for action control and outcome encoding, we hypothesized that adaptive responses to which these are essential functions, could also be targeted by stress. To test this hypothesis we herein assessed the impact of chronic stress in a Pavlovian-to-instrumental transfer (PIT) paradigm, a model of an adaptive response in which a previously conditioned cue biases an instrumental goal-directed action. Data reveals that rats submitted to chronic unpredictable stress did not display deficits in pavlovian conditioning nor on the learning of the instrumental task, but were impaired in PIT; importantly, after a stress-free period the PIT deficits were no longer observed. These results are relevant to understand how stress biases multiple incentive processes that contribute to instrumental performance.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
2012-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/19900
url http://hdl.handle.net/1822/19900
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-453X
10.3389/fnins.2012.00093
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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