Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs.
Autor(a) principal: | |
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Data de Publicação: | 1979 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334 |
Resumo: | Five anaesthetized open chested dogs were studied by measuring left anterior descending (LAD) coronary blood flow, at rest, after atrial pacing and after Isoprenaline infusion. The LAD was then stenosed in order to reduce the hyperaemic response and then the study was repeated. During the control situation LAD flow was shown to increase with the increase in heart rate. Although the partial occlusion did not drop resting coronary flow, it actually fell under stress conditions to 68 % of the control values. The importance of this observation is that although one might expect flow in a stenosed vessel to increase to a maximum limited by the stenosis, this in fact does not happen. lt appears that with increasing stress, local ischaemia produces a rise in coronary resistance. Such a mechanism may explain the occurrence of myocardial infarction without proximal occlusion of coronary vessels and may explain the discrepancy between the time course of myocardial infarction as observed following experimental coronary ligation and that seen in man. |
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spelling |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs.Five anaesthetized open chested dogs were studied by measuring left anterior descending (LAD) coronary blood flow, at rest, after atrial pacing and after Isoprenaline infusion. The LAD was then stenosed in order to reduce the hyperaemic response and then the study was repeated. During the control situation LAD flow was shown to increase with the increase in heart rate. Although the partial occlusion did not drop resting coronary flow, it actually fell under stress conditions to 68 % of the control values. The importance of this observation is that although one might expect flow in a stenosed vessel to increase to a maximum limited by the stenosis, this in fact does not happen. lt appears that with increasing stress, local ischaemia produces a rise in coronary resistance. Such a mechanism may explain the occurrence of myocardial infarction without proximal occlusion of coronary vessels and may explain the discrepancy between the time course of myocardial infarction as observed following experimental coronary ligation and that seen in man.Ordem dos Médicos1979-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334oai:ojs.www.actamedicaportuguesa.com:article/4334Acta Médica Portuguesa; Vol. 1 No. 2 (1979): 1979 Março-Abril; 203-207Acta Médica Portuguesa; Vol. 1 N.º 2 (1979): 1979 Março-Abril; 203-2071646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334/3404Seabra-Gomes, RRickards, A FParker, D Jinfo:eu-repo/semantics/openAccess2022-12-20T11:03:36Zoai:ojs.www.actamedicaportuguesa.com:article/4334Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:50.499434Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
title |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
spellingShingle |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. Seabra-Gomes, R |
title_short |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
title_full |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
title_fullStr |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
title_full_unstemmed |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
title_sort |
Effects of acute ischaemia induced by atrial pacing on coronary blood flow in dogs. |
author |
Seabra-Gomes, R |
author_facet |
Seabra-Gomes, R Rickards, A F Parker, D J |
author_role |
author |
author2 |
Rickards, A F Parker, D J |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Seabra-Gomes, R Rickards, A F Parker, D J |
description |
Five anaesthetized open chested dogs were studied by measuring left anterior descending (LAD) coronary blood flow, at rest, after atrial pacing and after Isoprenaline infusion. The LAD was then stenosed in order to reduce the hyperaemic response and then the study was repeated. During the control situation LAD flow was shown to increase with the increase in heart rate. Although the partial occlusion did not drop resting coronary flow, it actually fell under stress conditions to 68 % of the control values. The importance of this observation is that although one might expect flow in a stenosed vessel to increase to a maximum limited by the stenosis, this in fact does not happen. lt appears that with increasing stress, local ischaemia produces a rise in coronary resistance. Such a mechanism may explain the occurrence of myocardial infarction without proximal occlusion of coronary vessels and may explain the discrepancy between the time course of myocardial infarction as observed following experimental coronary ligation and that seen in man. |
publishDate |
1979 |
dc.date.none.fl_str_mv |
1979-04-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334 oai:ojs.www.actamedicaportuguesa.com:article/4334 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/4334 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4334/3404 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 1 No. 2 (1979): 1979 Março-Abril; 203-207 Acta Médica Portuguesa; Vol. 1 N.º 2 (1979): 1979 Março-Abril; 203-207 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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