Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis

• Autor(a) principal: Mancio, Jennifer
• Data de Publicação: 2020
• Outros Autores: Barros, António S., Conceicão, Glória, Santa, Cátia, Pessoa-Amorim, Guilherme, Bartosch, Carla, Fragao-Marques, Mariana, Ferreira, Wilson, Carvalho, Mónica, Ferreira, Nuno, Vouga, Luís, Miranda, Isabel M., Vitorino, Rui, Fontes-Carvalho, Ricardo, Manadas, Bruno, Falcão-Pires, Inês, Ribeiro, Vasco Gama, Leite-Moreira, Adelino, Bettencourt, Nuno
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/101329; https://doi.org/10.1016/j.repc.2020.03.017
• topic: Aterosclerose coronária; Computed tomography; Coronary atherosclerosis; EPICHEART study; Epicardial adipose tissue; Espectrometria de massa; Estudo EPICHEART; Mass spectrometry; Proteomics; Tecido adiposo epicárdico; Tomografia computadorizada; Adipose Tissue; Aged; Humans; Pericardium; Prospective Studies; Proteomics; Coronary Artery Disease

Accumulation of epicardial adipose tissue (EAT) is associated with coronary artery disease (CAD) and increased risk of coronary events in asymptomatic subjects and low-risk patients, suggesting that EAT promotes atherosclerosis in its early stage. Recent studies have shown that the presence of CAD affects the properties of adjacent EAT, leading to dynamic changes in the molecular players involved in the interplay between EAT and the coronary arteries over the history of the disease. The role of EAT in late-stage CAD has not been investigated.