Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/38659 |
Resumo: | Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter. |
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Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk MarkerEpicardial adipose tissueGenetic Risk Scoreatherosclerosiscardiovascular risk factorsgenetic polymorphismsEvidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter.SAGE JournalsRepositório ComumSousa, João AdrianoMendonca, Maria IsabelSerrão, MarcoBorges, SofiaHenriques, EvaFreitas, SóniaTentem, MargaridaSantos, MarinaFreitas, PedroFerreira, AntónioGuerra, GraçaDrumond, AntónioPalma Reis, Roberto2022-01-06T12:01:45Z2021-07-022021-07-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/38659engSousa JA, Mendonça MI, Serrão M, et al. Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker. Clin Med Insights Cardiol. 2021;15:11795468211029244. Published 2021 Jul 3. doi:10.1177/1179546821102924410.1177/11795468211029244info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-10T02:18:24Zoai:comum.rcaap.pt:10400.26/38659Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:34:34.421553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
title |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
spellingShingle |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker Sousa, João Adriano Epicardial adipose tissue Genetic Risk Score atherosclerosis cardiovascular risk factors genetic polymorphisms |
title_short |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
title_full |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
title_fullStr |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
title_full_unstemmed |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
title_sort |
Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker |
author |
Sousa, João Adriano |
author_facet |
Sousa, João Adriano Mendonca, Maria Isabel Serrão, Marco Borges, Sofia Henriques, Eva Freitas, Sónia Tentem, Margarida Santos, Marina Freitas, Pedro Ferreira, António Guerra, Graça Drumond, António Palma Reis, Roberto |
author_role |
author |
author2 |
Mendonca, Maria Isabel Serrão, Marco Borges, Sofia Henriques, Eva Freitas, Sónia Tentem, Margarida Santos, Marina Freitas, Pedro Ferreira, António Guerra, Graça Drumond, António Palma Reis, Roberto |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Sousa, João Adriano Mendonca, Maria Isabel Serrão, Marco Borges, Sofia Henriques, Eva Freitas, Sónia Tentem, Margarida Santos, Marina Freitas, Pedro Ferreira, António Guerra, Graça Drumond, António Palma Reis, Roberto |
dc.subject.por.fl_str_mv |
Epicardial adipose tissue Genetic Risk Score atherosclerosis cardiovascular risk factors genetic polymorphisms |
topic |
Epicardial adipose tissue Genetic Risk Score atherosclerosis cardiovascular risk factors genetic polymorphisms |
description |
Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-02 2021-07-02T00:00:00Z 2022-01-06T12:01:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/38659 |
url |
http://hdl.handle.net/10400.26/38659 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sousa JA, Mendonça MI, Serrão M, et al. Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker. Clin Med Insights Cardiol. 2021;15:11795468211029244. Published 2021 Jul 3. doi:10.1177/11795468211029244 10.1177/11795468211029244 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SAGE Journals |
publisher.none.fl_str_mv |
SAGE Journals |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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