Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker

Detalhes bibliográficos
Autor(a) principal: Sousa, João Adriano
Data de Publicação: 2021
Outros Autores: Mendonca, Maria Isabel, Serrão, Marco, Borges, Sofia, Henriques, Eva, Freitas, Sónia, Tentem, Margarida, Santos, Marina, Freitas, Pedro, Ferreira, António, Guerra, Graça, Drumond, António, Palma Reis, Roberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/38659
Resumo: Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter.
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spelling Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk MarkerEpicardial adipose tissueGenetic Risk Scoreatherosclerosiscardiovascular risk factorsgenetic polymorphismsEvidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter.SAGE JournalsRepositório ComumSousa, João AdrianoMendonca, Maria IsabelSerrão, MarcoBorges, SofiaHenriques, EvaFreitas, SóniaTentem, MargaridaSantos, MarinaFreitas, PedroFerreira, AntónioGuerra, GraçaDrumond, AntónioPalma Reis, Roberto2022-01-06T12:01:45Z2021-07-022021-07-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/38659engSousa JA, Mendonça MI, Serrão M, et al. Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker. Clin Med Insights Cardiol. 2021;15:11795468211029244. Published 2021 Jul 3. doi:10.1177/1179546821102924410.1177/11795468211029244info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-10T02:18:24Zoai:comum.rcaap.pt:10400.26/38659Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:34:34.421553Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
title Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
spellingShingle Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
Sousa, João Adriano
Epicardial adipose tissue
Genetic Risk Score
atherosclerosis
cardiovascular risk factors
genetic polymorphisms
title_short Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
title_full Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
title_fullStr Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
title_full_unstemmed Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
title_sort Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker
author Sousa, João Adriano
author_facet Sousa, João Adriano
Mendonca, Maria Isabel
Serrão, Marco
Borges, Sofia
Henriques, Eva
Freitas, Sónia
Tentem, Margarida
Santos, Marina
Freitas, Pedro
Ferreira, António
Guerra, Graça
Drumond, António
Palma Reis, Roberto
author_role author
author2 Mendonca, Maria Isabel
Serrão, Marco
Borges, Sofia
Henriques, Eva
Freitas, Sónia
Tentem, Margarida
Santos, Marina
Freitas, Pedro
Ferreira, António
Guerra, Graça
Drumond, António
Palma Reis, Roberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Sousa, João Adriano
Mendonca, Maria Isabel
Serrão, Marco
Borges, Sofia
Henriques, Eva
Freitas, Sónia
Tentem, Margarida
Santos, Marina
Freitas, Pedro
Ferreira, António
Guerra, Graça
Drumond, António
Palma Reis, Roberto
dc.subject.por.fl_str_mv Epicardial adipose tissue
Genetic Risk Score
atherosclerosis
cardiovascular risk factors
genetic polymorphisms
topic Epicardial adipose tissue
Genetic Risk Score
atherosclerosis
cardiovascular risk factors
genetic polymorphisms
description Evidence points epicardial adipose tissue (EAT) as an emerging cardiovascular risk marker. Whether genetic polymorphisms linked with atherosclerosis are associated with higher EAT is still unknown. We aim to assess the role of genetic burden of atherosclerosis and its association to EAT in a cohort of asymptomatic individuals without coronary disease. A total of 996 participants were prospectively enrolled in a single Portuguese center. EAT volume was measured by Cardiac Computed Tomography and participants were distributed into 2 groups, above and below median EAT. SNPs were genotyped and linked to their respective pathophysiological axes. A multiplicative genetic risk score (mGRS) was constructed, representing the genetic burden of the studied SNPs. To evaluate the association between genetics and EAT, we compared both groups by global mGRS, mGRS by functional axes, and SNPs individually. Individuals above-median EAT were older, had a higher body mass index (BMI) and higher prevalence of hypertension, metabolic syndrome, diabetes, and dyslipidemia. They presented higher GRS, that remained an independent predictor of higher EAT volumes. The group with more EAT consistently presented higher polymorphic burden across numerous pathways. After adjustment, age, BMI, and mGRS of each functional axis emerged as independently related to higher EAT volumes. Amongst the 33 SNPs, MTHFR677 polymorphism emerged as the only significant and independent predictor of higher EAT volumes. Patients with higher polymorphism burden for atherosclerosis present higher EAT volumes. We present the first study in a Portuguese population, evaluating the genetic profile of EAT through GWAS and GRS, casting further insight into this complicated matter.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-02
2021-07-02T00:00:00Z
2022-01-06T12:01:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/38659
url http://hdl.handle.net/10400.26/38659
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sousa JA, Mendonça MI, Serrão M, et al. Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker. Clin Med Insights Cardiol. 2021;15:11795468211029244. Published 2021 Jul 3. doi:10.1177/11795468211029244
10.1177/11795468211029244
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SAGE Journals
publisher.none.fl_str_mv SAGE Journals
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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