Prevalence and risk factors of fatty liver in Portuguese adults
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/7346 |
Resumo: | Background: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly selected in 834 Portuguese adults (18-79 years). Participants were evaluated after 12-hour fasting. Anthropometric data, past history including alcohol consumption, and associated diseases were registered. Blood samples were collected for biochemical testing. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire. Presence of FL was evaluated using ultrasound, and NAFLD was diagnosed after exclusion of other causes for liver disease. Results: Adjusted prevalence of FL and NAFLD was 37.8% and 17.0%, respectively. FL individuals were older, more frequently males, with increased probability of having obesity, diabetes or harmful alcohol consumption (HAC). NAFLD individuals were also older, but had a similar sex distribution and an increased probability of obesity and diabetes. In both groups, no differences were found regarding dietary pattern or physical activity. During the same time period, nonalcoholic steatohepatitis (NASH) liver-related deaths in Portugal were 0.105/100 000, while alcohol-related liver disease mortality was 6.790/100 000. Conclusion: The large spectrum of FL was present in more than one third of the population, although only less than half could be classified as NAFLD. Other significant risk factors, such as HAC, are probably implicated in FL, explaining the low NASH-related mortality compared with the high alcohol-related mortality during the same time period. |
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Prevalence and risk factors of fatty liver in Portuguese adultsAlcohol ConsumptionDiabetesFatty LiverMortalityNonalcoholic Fatty LiverNutritional PatternObesityDoenças Cardio e Cérebro-vascularesPortugalBackground: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly selected in 834 Portuguese adults (18-79 years). Participants were evaluated after 12-hour fasting. Anthropometric data, past history including alcohol consumption, and associated diseases were registered. Blood samples were collected for biochemical testing. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire. Presence of FL was evaluated using ultrasound, and NAFLD was diagnosed after exclusion of other causes for liver disease. Results: Adjusted prevalence of FL and NAFLD was 37.8% and 17.0%, respectively. FL individuals were older, more frequently males, with increased probability of having obesity, diabetes or harmful alcohol consumption (HAC). NAFLD individuals were also older, but had a similar sex distribution and an increased probability of obesity and diabetes. In both groups, no differences were found regarding dietary pattern or physical activity. During the same time period, nonalcoholic steatohepatitis (NASH) liver-related deaths in Portugal were 0.105/100 000, while alcohol-related liver disease mortality was 6.790/100 000. Conclusion: The large spectrum of FL was present in more than one third of the population, although only less than half could be classified as NAFLD. Other significant risk factors, such as HAC, are probably implicated in FL, explaining the low NASH-related mortality compared with the high alcohol-related mortality during the same time period.The present study received grants from: Portuguese Association for the Study of the Liver (APEF), Gilead Foundation and Gilead Genesis and Roche supplied laboratorial kits. APEF, Gilead Foundation and Gilead Genesis and Roche had no role in the design, analysis or writing of this article, and in the decision to submit the article for publication.Wiley/ Stichting European Society for Clinical Investigation Journal FoundationRepositório Científico do Instituto Nacional de SaúdeLeitão, JorgeCarvalhana, SofiaCochicho, JoanaSilva, Ana PaulaVelasco, FranciscoMedeiros, IsabelAlves, Ana CatarinaBourbon, MafaldaOliveiros, BárbaraRodrigues, VitorSousa, RitaSampaio, FilipaCarvalho, ArmandoCortez‐Pinto, Helena2021-03-06T15:47:51Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7346engEur J Clin Invest. 2020 Jun;50(6):e13235. doi: 10.1111/eci.13235. Epub 2020 May 190014-297210.1111/eci.13235info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:54Zoai:repositorio.insa.pt:10400.18/7346Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:55.361586Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Prevalence and risk factors of fatty liver in Portuguese adults |
title |
Prevalence and risk factors of fatty liver in Portuguese adults |
spellingShingle |
Prevalence and risk factors of fatty liver in Portuguese adults Leitão, Jorge Alcohol Consumption Diabetes Fatty Liver Mortality Nonalcoholic Fatty Liver Nutritional Pattern Obesity Doenças Cardio e Cérebro-vasculares Portugal |
title_short |
Prevalence and risk factors of fatty liver in Portuguese adults |
title_full |
Prevalence and risk factors of fatty liver in Portuguese adults |
title_fullStr |
Prevalence and risk factors of fatty liver in Portuguese adults |
title_full_unstemmed |
Prevalence and risk factors of fatty liver in Portuguese adults |
title_sort |
Prevalence and risk factors of fatty liver in Portuguese adults |
author |
Leitão, Jorge |
author_facet |
Leitão, Jorge Carvalhana, Sofia Cochicho, Joana Silva, Ana Paula Velasco, Francisco Medeiros, Isabel Alves, Ana Catarina Bourbon, Mafalda Oliveiros, Bárbara Rodrigues, Vitor Sousa, Rita Sampaio, Filipa Carvalho, Armando Cortez‐Pinto, Helena |
author_role |
author |
author2 |
Carvalhana, Sofia Cochicho, Joana Silva, Ana Paula Velasco, Francisco Medeiros, Isabel Alves, Ana Catarina Bourbon, Mafalda Oliveiros, Bárbara Rodrigues, Vitor Sousa, Rita Sampaio, Filipa Carvalho, Armando Cortez‐Pinto, Helena |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Leitão, Jorge Carvalhana, Sofia Cochicho, Joana Silva, Ana Paula Velasco, Francisco Medeiros, Isabel Alves, Ana Catarina Bourbon, Mafalda Oliveiros, Bárbara Rodrigues, Vitor Sousa, Rita Sampaio, Filipa Carvalho, Armando Cortez‐Pinto, Helena |
dc.subject.por.fl_str_mv |
Alcohol Consumption Diabetes Fatty Liver Mortality Nonalcoholic Fatty Liver Nutritional Pattern Obesity Doenças Cardio e Cérebro-vasculares Portugal |
topic |
Alcohol Consumption Diabetes Fatty Liver Mortality Nonalcoholic Fatty Liver Nutritional Pattern Obesity Doenças Cardio e Cérebro-vasculares Portugal |
description |
Background: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly selected in 834 Portuguese adults (18-79 years). Participants were evaluated after 12-hour fasting. Anthropometric data, past history including alcohol consumption, and associated diseases were registered. Blood samples were collected for biochemical testing. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire. Presence of FL was evaluated using ultrasound, and NAFLD was diagnosed after exclusion of other causes for liver disease. Results: Adjusted prevalence of FL and NAFLD was 37.8% and 17.0%, respectively. FL individuals were older, more frequently males, with increased probability of having obesity, diabetes or harmful alcohol consumption (HAC). NAFLD individuals were also older, but had a similar sex distribution and an increased probability of obesity and diabetes. In both groups, no differences were found regarding dietary pattern or physical activity. During the same time period, nonalcoholic steatohepatitis (NASH) liver-related deaths in Portugal were 0.105/100 000, while alcohol-related liver disease mortality was 6.790/100 000. Conclusion: The large spectrum of FL was present in more than one third of the population, although only less than half could be classified as NAFLD. Other significant risk factors, such as HAC, are probably implicated in FL, explaining the low NASH-related mortality compared with the high alcohol-related mortality during the same time period. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06 2020-06-01T00:00:00Z 2021-03-06T15:47:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/7346 |
url |
http://hdl.handle.net/10400.18/7346 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Eur J Clin Invest. 2020 Jun;50(6):e13235. doi: 10.1111/eci.13235. Epub 2020 May 19 0014-2972 10.1111/eci.13235 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley/ Stichting European Society for Clinical Investigation Journal Foundation |
publisher.none.fl_str_mv |
Wiley/ Stichting European Society for Clinical Investigation Journal Foundation |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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