The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings

Detalhes bibliográficos
Autor(a) principal: Navarro-Sempere, Alicia
Data de Publicação: 2021
Outros Autores: Martínez-Peinado, Pascual, Rodrigues, Armindo, Garcia, Patrícia, Camarinho, Ricardo, García, Magdalena, Segovia, Yolanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/6194
Resumo: Neuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants.
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spelling The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic SurroundingsCell BiologyImmunologyHealth HazardsVolcanoesNeuroinflammationNeuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants.HindawiRepositório da Universidade dos AçoresNavarro-Sempere, AliciaMartínez-Peinado, PascualRodrigues, ArmindoGarcia, PatríciaCamarinho, RicardoGarcía, MagdalenaSegovia, Yolanda2022-02-14T11:36:14Z2021-102021-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/6194engNavarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A.S., Garcia, P.V., Camarinho, R., García, M. & Segovia, Y. (2021). The health hazards of volcanoes: first evidence of neuroinflammation in the hippocampus of mice exposed to active volcanic surroundings. “Mediators of Inflammation”, 2021, 5891095. DOI: 10.1155/2021/58910950962-935110.1155/2021/58910951466-1861PMC852323534671225info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:34:38Zoai:repositorio.uac.pt:10400.3/6194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:28:21.945486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
title The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
spellingShingle The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
Navarro-Sempere, Alicia
Cell Biology
Immunology
Health Hazards
Volcanoes
Neuroinflammation
title_short The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
title_full The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
title_fullStr The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
title_full_unstemmed The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
title_sort The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
author Navarro-Sempere, Alicia
author_facet Navarro-Sempere, Alicia
Martínez-Peinado, Pascual
Rodrigues, Armindo
Garcia, Patrícia
Camarinho, Ricardo
García, Magdalena
Segovia, Yolanda
author_role author
author2 Martínez-Peinado, Pascual
Rodrigues, Armindo
Garcia, Patrícia
Camarinho, Ricardo
García, Magdalena
Segovia, Yolanda
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Navarro-Sempere, Alicia
Martínez-Peinado, Pascual
Rodrigues, Armindo
Garcia, Patrícia
Camarinho, Ricardo
García, Magdalena
Segovia, Yolanda
dc.subject.por.fl_str_mv Cell Biology
Immunology
Health Hazards
Volcanoes
Neuroinflammation
topic Cell Biology
Immunology
Health Hazards
Volcanoes
Neuroinflammation
description Neuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
2021-10-01T00:00:00Z
2022-02-14T11:36:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/6194
url http://hdl.handle.net/10400.3/6194
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Navarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A.S., Garcia, P.V., Camarinho, R., García, M. & Segovia, Y. (2021). The health hazards of volcanoes: first evidence of neuroinflammation in the hippocampus of mice exposed to active volcanic surroundings. “Mediators of Inflammation”, 2021, 5891095. DOI: 10.1155/2021/5891095
0962-9351
10.1155/2021/5891095
1466-1861
PMC8523235
34671225
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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