The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.3/6194 |
Resumo: | Neuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants. |
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The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic SurroundingsCell BiologyImmunologyHealth HazardsVolcanoesNeuroinflammationNeuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants.HindawiRepositório da Universidade dos AçoresNavarro-Sempere, AliciaMartínez-Peinado, PascualRodrigues, ArmindoGarcia, PatríciaCamarinho, RicardoGarcía, MagdalenaSegovia, Yolanda2022-02-14T11:36:14Z2021-102021-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/6194engNavarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A.S., Garcia, P.V., Camarinho, R., García, M. & Segovia, Y. (2021). The health hazards of volcanoes: first evidence of neuroinflammation in the hippocampus of mice exposed to active volcanic surroundings. “Mediators of Inflammation”, 2021, 5891095. DOI: 10.1155/2021/58910950962-935110.1155/2021/58910951466-1861PMC852323534671225info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:34:38Zoai:repositorio.uac.pt:10400.3/6194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:28:21.945486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
title |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
spellingShingle |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings Navarro-Sempere, Alicia Cell Biology Immunology Health Hazards Volcanoes Neuroinflammation |
title_short |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
title_full |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
title_fullStr |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
title_full_unstemmed |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
title_sort |
The Health Hazards of Volcanoes : First Evidence of Neuroinflammation in the Hippocampus of Mice Exposed to Active Volcanic Surroundings |
author |
Navarro-Sempere, Alicia |
author_facet |
Navarro-Sempere, Alicia Martínez-Peinado, Pascual Rodrigues, Armindo Garcia, Patrícia Camarinho, Ricardo García, Magdalena Segovia, Yolanda |
author_role |
author |
author2 |
Martínez-Peinado, Pascual Rodrigues, Armindo Garcia, Patrícia Camarinho, Ricardo García, Magdalena Segovia, Yolanda |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade dos Açores |
dc.contributor.author.fl_str_mv |
Navarro-Sempere, Alicia Martínez-Peinado, Pascual Rodrigues, Armindo Garcia, Patrícia Camarinho, Ricardo García, Magdalena Segovia, Yolanda |
dc.subject.por.fl_str_mv |
Cell Biology Immunology Health Hazards Volcanoes Neuroinflammation |
topic |
Cell Biology Immunology Health Hazards Volcanoes Neuroinflammation |
description |
Neuroinflammation is a process related to the onset of neurodegenerative diseases; one of the hallmarks of this process is microglial reactivation and the secretion by these cells of proinflammatory cytokines such as TNFα. Numerous studies report the relationship between neuroinflammatory processes and exposure to anthropogenic air pollutants, but few refer to natural pollutants. Volcanoes are highly inhabited natural sources of environmental pollution that induce changes in the nervous system, such as reactive astrogliosis or the blood-brain barrier breakdown in exposed individuals; however, no neuroinflammatory event has been yet defined. To this purpose, we studied resting microglia, reactive microglia, and TNFα production in the brains of mice chronically exposed to an active volcanic environment on the island of São Miguel (Azores, Portugal). For the first time, we demonstrate a proliferation of microglial cells and an increase in reactive microglia, as well an increase in TNFα secretion, in the central nervous system of individuals exposed to volcanogenic pollutants. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10 2021-10-01T00:00:00Z 2022-02-14T11:36:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.3/6194 |
url |
http://hdl.handle.net/10400.3/6194 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Navarro-Sempere, A., Martínez-Peinado, P., Rodrigues, A.S., Garcia, P.V., Camarinho, R., García, M. & Segovia, Y. (2021). The health hazards of volcanoes: first evidence of neuroinflammation in the hippocampus of mice exposed to active volcanic surroundings. “Mediators of Inflammation”, 2021, 5891095. DOI: 10.1155/2021/5891095 0962-9351 10.1155/2021/5891095 1466-1861 PMC8523235 34671225 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi |
publisher.none.fl_str_mv |
Hindawi |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130740994080768 |