Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester

Detalhes bibliográficos
Autor(a) principal: Chiplunkar, Pranali P.
Data de Publicação: 2018
Outros Autores: Zhao, Xiaoman, Tomke, Prerana D., Noro, Jennifer, Xu, B., Wang, Qiang, Silva, Carla, Pratap, Amit P., Cavaco-Paulo, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/47807
Resumo: Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.ultsonch.2017.08.004.
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spelling Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl esterHydrolysisAspirin methyl esterLipaseUltrasoundWaterScience & TechnologySupplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.ultsonch.2017.08.004.The ultrasound-assisted hydrolysis of aspirin methyl ester (AME) was investigated using immobilized Candida antarctica lipase B (CALB) (1%) in the presence of solvents like triolein, chloroform (CHCl3) and dichloromethane (DCM). The effect of ultrasound and the role of water on the conversion rates have also been investigated. Proton nuclear magnetic resonance spectroscopic (1H NMR) was chosen to calculate hydrolysis convertion rates. We observed that lipase-ultrasound assisted hydrolysis of AME in the presence of triolein and water showed the highest hydrolysis conversion rate (65.3%). Herein low water amount played an important role as a nucleophile being crucial for the hydrolysis yields obtained. Lipase activity was affected by the conjugated action of ultrasound and solvents (35.75% of decrease), however not disturbing its hydrolytic efficiency. It was demonstrated that lipase is able to hydrolyse AME to methyl 2-hydroxy benzoate (methyl salicylate), which applications include fragrance agents in food, beverages and cosmetics, or analgesic agent in liniments.All authors gratefully acknowledge the financial support provided by International Joint Research Laboratory for Textile and Fibre Bioprocesses at Jiangnan University. The authors are also thankful to the Department of Oils, Oleochemicals and Surfactants technology, Institute of Chemical Technology, Mumbai, India and to the Bioprocess and Bio nanotechnology Research Group (BBRG) of University of Minho. Authors would like also to acknowledge the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020 – Programa Operacional Regional do Norte and to the Fundamental Research Funds for the Central Universities (No. JUSRP51622 A and No. JUSRP115A03), and to the Jiangsu Province Scientific Research Innovation Project for Academic Graduate Students in 2016 (No. KYLX16_0788).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoChiplunkar, Pranali P.Zhao, XiaomanTomke, Prerana D.Noro, JenniferXu, B.Wang, QiangSilva, CarlaPratap, Amit P.Cavaco-Paulo, Artur20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/47807engChiplunkar, Pranali P.; Zhao, Xiaoman; Prerana D. Tomke; Jennifer Noro; Xu, B.; Wang, Qiang; Silva, Carla; Pratap, Amit P.; Cavaco-Paulo, Artur, Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester. Ultrasonics Sonochemistry, 40(Part A), 587-593, 20181350-417710.1016/j.ultsonch.2017.08.00428946463http://www.journals.elsevier.com/ultrasonics-sonochemistry/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:12Zoai:repositorium.sdum.uminho.pt:1822/47807Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:17.998903Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
title Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
spellingShingle Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
Chiplunkar, Pranali P.
Hydrolysis
Aspirin methyl ester
Lipase
Ultrasound
Water
Science & Technology
title_short Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
title_full Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
title_fullStr Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
title_full_unstemmed Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
title_sort Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester
author Chiplunkar, Pranali P.
author_facet Chiplunkar, Pranali P.
Zhao, Xiaoman
Tomke, Prerana D.
Noro, Jennifer
Xu, B.
Wang, Qiang
Silva, Carla
Pratap, Amit P.
Cavaco-Paulo, Artur
author_role author
author2 Zhao, Xiaoman
Tomke, Prerana D.
Noro, Jennifer
Xu, B.
Wang, Qiang
Silva, Carla
Pratap, Amit P.
Cavaco-Paulo, Artur
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Chiplunkar, Pranali P.
Zhao, Xiaoman
Tomke, Prerana D.
Noro, Jennifer
Xu, B.
Wang, Qiang
Silva, Carla
Pratap, Amit P.
Cavaco-Paulo, Artur
dc.subject.por.fl_str_mv Hydrolysis
Aspirin methyl ester
Lipase
Ultrasound
Water
Science & Technology
topic Hydrolysis
Aspirin methyl ester
Lipase
Ultrasound
Water
Science & Technology
description Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.ultsonch.2017.08.004.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/47807
url http://hdl.handle.net/1822/47807
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chiplunkar, Pranali P.; Zhao, Xiaoman; Prerana D. Tomke; Jennifer Noro; Xu, B.; Wang, Qiang; Silva, Carla; Pratap, Amit P.; Cavaco-Paulo, Artur, Ultrasound-assisted lipase catalyzed hydrolysis of aspirin methyl ester. Ultrasonics Sonochemistry, 40(Part A), 587-593, 2018
1350-4177
10.1016/j.ultsonch.2017.08.004
28946463
http://www.journals.elsevier.com/ultrasonics-sonochemistry/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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