Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort

Detalhes bibliográficos
Autor(a) principal: Santos, V.
Data de Publicação: 2020
Outros Autores: Martins, N., Sousa, C., Jacob, M., Padrão, E., Melo, N., Mota, P. Caetano, Bastos, H.N., Guimarães, S., Moura, C. Souto, Sokhatska, O., Cunha, R., Pereira, J., Morais, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2702
Resumo: Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) which varies in prevalence across the world, depending on disease definition, diagnostic methods, exposure type and intensity, geographical environments, agricultural and industrial practices, and host risk factors. This study aimed to deepen knowledge about HP's clinical characteristics, diagnosis and functional and imaging features in a cohort of HP patients from the North of Portugal. To achieve this goal, a retrospective assessment of the clinical and diagnostic data was carried out, and patients were classified and compared according to disease presentation (acute, sub-acute and chronic HP forms). Of the 209 HP patients included (mean age 58.3 ± 16.0 years), 52.6% were female and 73.7% presented a chronic form. Most patients had prior exposure to birds (76.6%). Dyspnoea and cough were the most frequently experienced symptoms, but no statistically significant differences were found between groups (p = 0.089, p = 0.418, respectively). Fever was most common in acute HP form (p < 0.001). The most common patterns found in Chest CT were ground glass (p = 0.002) in acute/subacute presentation, and reticulation (p < 0.001) in chronic form, while mosaic attenuation, although was also frequently observed, no statistically significant differences were found between groups (p = 0.512). The most common functional pattern was restrictive (38% of patients, 73.7% with chronic HP form). Bronchoalveolar lavage lymphocytes were higher in acute and subacute forms although not reaching statistical significance (p = 0.072), with lowest CD4/CD8 ratio (p = 0.001) in acute forms. Thus, given the significant disease heterogeneity, further studies with different populations and ambient exposures are needed to achieve a better stratification of the exposure risk, to provide proper implementation of avoidance methods and a precise diagnostic and therapeutic approach.
id RCAP_08e573679a7a4efee044f868aa6a64b3
oai_identifier_str oai:repositorio.chporto.pt:10400.16/2702
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohortAntigens exposureHypersensitivity pneumonitisInterstitial lung diseaseHypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) which varies in prevalence across the world, depending on disease definition, diagnostic methods, exposure type and intensity, geographical environments, agricultural and industrial practices, and host risk factors. This study aimed to deepen knowledge about HP's clinical characteristics, diagnosis and functional and imaging features in a cohort of HP patients from the North of Portugal. To achieve this goal, a retrospective assessment of the clinical and diagnostic data was carried out, and patients were classified and compared according to disease presentation (acute, sub-acute and chronic HP forms). Of the 209 HP patients included (mean age 58.3 ± 16.0 years), 52.6% were female and 73.7% presented a chronic form. Most patients had prior exposure to birds (76.6%). Dyspnoea and cough were the most frequently experienced symptoms, but no statistically significant differences were found between groups (p = 0.089, p = 0.418, respectively). Fever was most common in acute HP form (p < 0.001). The most common patterns found in Chest CT were ground glass (p = 0.002) in acute/subacute presentation, and reticulation (p < 0.001) in chronic form, while mosaic attenuation, although was also frequently observed, no statistically significant differences were found between groups (p = 0.512). The most common functional pattern was restrictive (38% of patients, 73.7% with chronic HP form). Bronchoalveolar lavage lymphocytes were higher in acute and subacute forms although not reaching statistical significance (p = 0.072), with lowest CD4/CD8 ratio (p = 0.001) in acute forms. Thus, given the significant disease heterogeneity, further studies with different populations and ambient exposures are needed to achieve a better stratification of the exposure risk, to provide proper implementation of avoidance methods and a precise diagnostic and therapeutic approach.ElsevierRepositório Científico do Centro Hospitalar Universitário de Santo AntónioSantos, V.Martins, N.Sousa, C.Jacob, M.Padrão, E.Melo, N.Mota, P. CaetanoBastos, H.N.Guimarães, S.Moura, C. SoutoSokhatska, O.Cunha, R.Pereira, J.Morais, A.2022-07-11T15:35:50Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2702engSantos V, Martins N, Sousa C, et al. Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort. Pulmonology. 2020;26(3):130-137. doi:10.1016/j.pulmoe.2019.09.0042531-043710.1016/j.pulmoe.2019.09.004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:01:49Zoai:repositorio.chporto.pt:10400.16/2702Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:53.798875Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
title Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
spellingShingle Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
Santos, V.
Antigens exposure
Hypersensitivity pneumonitis
Interstitial lung disease
title_short Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
title_full Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
title_fullStr Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
title_full_unstemmed Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
title_sort Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort
author Santos, V.
author_facet Santos, V.
Martins, N.
Sousa, C.
Jacob, M.
Padrão, E.
Melo, N.
Mota, P. Caetano
Bastos, H.N.
Guimarães, S.
Moura, C. Souto
Sokhatska, O.
Cunha, R.
Pereira, J.
Morais, A.
author_role author
author2 Martins, N.
Sousa, C.
Jacob, M.
Padrão, E.
Melo, N.
Mota, P. Caetano
Bastos, H.N.
Guimarães, S.
Moura, C. Souto
Sokhatska, O.
Cunha, R.
Pereira, J.
Morais, A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Santos, V.
Martins, N.
Sousa, C.
Jacob, M.
Padrão, E.
Melo, N.
Mota, P. Caetano
Bastos, H.N.
Guimarães, S.
Moura, C. Souto
Sokhatska, O.
Cunha, R.
Pereira, J.
Morais, A.
dc.subject.por.fl_str_mv Antigens exposure
Hypersensitivity pneumonitis
Interstitial lung disease
topic Antigens exposure
Hypersensitivity pneumonitis
Interstitial lung disease
description Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) which varies in prevalence across the world, depending on disease definition, diagnostic methods, exposure type and intensity, geographical environments, agricultural and industrial practices, and host risk factors. This study aimed to deepen knowledge about HP's clinical characteristics, diagnosis and functional and imaging features in a cohort of HP patients from the North of Portugal. To achieve this goal, a retrospective assessment of the clinical and diagnostic data was carried out, and patients were classified and compared according to disease presentation (acute, sub-acute and chronic HP forms). Of the 209 HP patients included (mean age 58.3 ± 16.0 years), 52.6% were female and 73.7% presented a chronic form. Most patients had prior exposure to birds (76.6%). Dyspnoea and cough were the most frequently experienced symptoms, but no statistically significant differences were found between groups (p = 0.089, p = 0.418, respectively). Fever was most common in acute HP form (p < 0.001). The most common patterns found in Chest CT were ground glass (p = 0.002) in acute/subacute presentation, and reticulation (p < 0.001) in chronic form, while mosaic attenuation, although was also frequently observed, no statistically significant differences were found between groups (p = 0.512). The most common functional pattern was restrictive (38% of patients, 73.7% with chronic HP form). Bronchoalveolar lavage lymphocytes were higher in acute and subacute forms although not reaching statistical significance (p = 0.072), with lowest CD4/CD8 ratio (p = 0.001) in acute forms. Thus, given the significant disease heterogeneity, further studies with different populations and ambient exposures are needed to achieve a better stratification of the exposure risk, to provide proper implementation of avoidance methods and a precise diagnostic and therapeutic approach.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2022-07-11T15:35:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2702
url http://hdl.handle.net/10400.16/2702
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Santos V, Martins N, Sousa C, et al. Hypersensitivity pneumonitis: Main features characterization in a Portuguese cohort. Pulmonology. 2020;26(3):130-137. doi:10.1016/j.pulmoe.2019.09.004
2531-0437
10.1016/j.pulmoe.2019.09.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133649097981952