Membrane proteins structures: A review on computational modeling tools

Detalhes bibliográficos
Autor(a) principal: Almeida, Jose G.
Data de Publicação: 2017
Outros Autores: Preto, Antonio J., Koukos, Panagiotis I., Bonvin, Alexandre M. J. J., Moreira, Irina S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/48362
https://doi.org/10.1016/j.bbamem.2017.07.008
Resumo: Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights.
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spelling Membrane proteins structures: A review on computational modeling toolsAlgorithmsComputational BiologyHumansMembrane ProteinsMolecular Dynamics SimulationSoftwareMembrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights.2017-07-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/48362http://hdl.handle.net/10316/48362https://doi.org/10.1016/j.bbamem.2017.07.008enghttps://www.sciencedirect.com/science/article/pii/S000527361730233X?via%3DihubAlmeida, Jose G.Preto, Antonio J.Koukos, Panagiotis I.Bonvin, Alexandre M. J. J.Moreira, Irina S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-07-26T15:14:27Zoai:estudogeral.uc.pt:10316/48362Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:39.062188Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Membrane proteins structures: A review on computational modeling tools
title Membrane proteins structures: A review on computational modeling tools
spellingShingle Membrane proteins structures: A review on computational modeling tools
Almeida, Jose G.
Algorithms
Computational Biology
Humans
Membrane Proteins
Molecular Dynamics Simulation
Software
title_short Membrane proteins structures: A review on computational modeling tools
title_full Membrane proteins structures: A review on computational modeling tools
title_fullStr Membrane proteins structures: A review on computational modeling tools
title_full_unstemmed Membrane proteins structures: A review on computational modeling tools
title_sort Membrane proteins structures: A review on computational modeling tools
author Almeida, Jose G.
author_facet Almeida, Jose G.
Preto, Antonio J.
Koukos, Panagiotis I.
Bonvin, Alexandre M. J. J.
Moreira, Irina S.
author_role author
author2 Preto, Antonio J.
Koukos, Panagiotis I.
Bonvin, Alexandre M. J. J.
Moreira, Irina S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Jose G.
Preto, Antonio J.
Koukos, Panagiotis I.
Bonvin, Alexandre M. J. J.
Moreira, Irina S.
dc.subject.por.fl_str_mv Algorithms
Computational Biology
Humans
Membrane Proteins
Molecular Dynamics Simulation
Software
topic Algorithms
Computational Biology
Humans
Membrane Proteins
Molecular Dynamics Simulation
Software
description Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/48362
http://hdl.handle.net/10316/48362
https://doi.org/10.1016/j.bbamem.2017.07.008
url http://hdl.handle.net/10316/48362
https://doi.org/10.1016/j.bbamem.2017.07.008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S000527361730233X?via%3Dihub
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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