Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents

Detalhes bibliográficos
Autor(a) principal: Popović, Boris M.
Data de Publicação: 2023
Outros Autores: Gligorijević, Nevenka, Aranđelović, Sandra, Macedo, Ana Catarina, Jurić, Tatjana, Uka, Denis, Mocko-Blažek, Karolina, Serra, Ana Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158532
Resumo: grant no. 7731993, Active Pharmaceutical Ingredient Deep Eutectic Solvents as Novel Therapeutic Agents and Food Supplements – APIDES, and the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant no. 451-03-68/2022-14/200117 and grant no. 451-03-68/2022-14/200043. Publisher Copyright: © 2023 The Royal Society of Chemistry.
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spelling Cytotoxicity profiling of choline chloride-based natural deep eutectic solventsChemistry(all)Chemical Engineering(all)grant no. 7731993, Active Pharmaceutical Ingredient Deep Eutectic Solvents as Novel Therapeutic Agents and Food Supplements – APIDES, and the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant no. 451-03-68/2022-14/200117 and grant no. 451-03-68/2022-14/200043. Publisher Copyright: © 2023 The Royal Society of Chemistry.This study aims to examine in detail for the first time the cytotoxic profile of twelve choline chloride-based deep eutectic solvents (NADES) against HT-29, Caco-2, MCF-7, and MRC-5 cell lines. All NADES systems were synthesized by microwave synthesis using choline chloride as a hydrogen bond acceptor (HBA) and selected sugars, alcohols, organic acids, and urea as hydrogen bond donors (HBD) with the addition of 20% water (w/w) to all systems. It was observed that the cytotoxic effect predominantly depended on the structure of HBD. Acidic systems, where HBDs were organic acids showed the highest cytotoxic effects in all investigated cell lines. The cytotoxicity depended mostly on the concentration of the NADES system in the cell medium as well as on the chemical constitution of the investigated systems. The highest cytotoxic effects showed acidic systems, especially to the HT-29 cell line. The EC50 value for the citric acid-based system was 3.91 mg mL−1 for the HT-29 cell line which was the most vulnerable to acidic NADES systems.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNPopović, Boris M.Gligorijević, NevenkaAranđelović, SandraMacedo, Ana CatarinaJurić, TatjanaUka, DenisMocko-Blažek, KarolinaSerra, Ana Teresa2023-09-30T22:19:32Z2023-01-252023-01-25T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/158532eng2046-2069PURE: 72431293https://doi.org/10.1039/d2ra07488einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:41:00Zoai:run.unl.pt:10362/158532Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:11.657078Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
title Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
spellingShingle Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
Popović, Boris M.
Chemistry(all)
Chemical Engineering(all)
title_short Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
title_full Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
title_fullStr Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
title_full_unstemmed Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
title_sort Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents
author Popović, Boris M.
author_facet Popović, Boris M.
Gligorijević, Nevenka
Aranđelović, Sandra
Macedo, Ana Catarina
Jurić, Tatjana
Uka, Denis
Mocko-Blažek, Karolina
Serra, Ana Teresa
author_role author
author2 Gligorijević, Nevenka
Aranđelović, Sandra
Macedo, Ana Catarina
Jurić, Tatjana
Uka, Denis
Mocko-Blažek, Karolina
Serra, Ana Teresa
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Popović, Boris M.
Gligorijević, Nevenka
Aranđelović, Sandra
Macedo, Ana Catarina
Jurić, Tatjana
Uka, Denis
Mocko-Blažek, Karolina
Serra, Ana Teresa
dc.subject.por.fl_str_mv Chemistry(all)
Chemical Engineering(all)
topic Chemistry(all)
Chemical Engineering(all)
description grant no. 7731993, Active Pharmaceutical Ingredient Deep Eutectic Solvents as Novel Therapeutic Agents and Food Supplements – APIDES, and the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant no. 451-03-68/2022-14/200117 and grant no. 451-03-68/2022-14/200043. Publisher Copyright: © 2023 The Royal Society of Chemistry.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-30T22:19:32Z
2023-01-25
2023-01-25T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158532
url http://hdl.handle.net/10362/158532
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2046-2069
PURE: 72431293
https://doi.org/10.1039/d2ra07488e
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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