The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization

Detalhes bibliográficos
Autor(a) principal: De Falco, Louis
Data de Publicação: 2021
Outros Autores: Silva, Nelly, Santos, Nuno C., Huber, Roland G., Martins, Ivo C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49529
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularizationRNA structureCircular RNACircular genomesFlavivirusVirus genomes© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).The circularization of viral genomes fulfills various functions, from evading host defense mechanisms to promoting specific replication and translation patterns supporting viral proliferation. Here, we describe the genomic structures and associated host factors important for flaviviruses genome circularization and summarize their functional roles. Flaviviruses are relatively small, single-stranded, positive-sense RNA viruses with genomes of approximately 11 kb in length. These genomes contain motifs at their 5' and 3' ends, as well as in other regions, that are involved in circularization. These motifs are highly conserved throughout the Flavivirus genus and occur both in mature virions and within infected cells. We provide an overview of these sequence motifs and RNA structures involved in circularization, describe their linear and circularized structures, and discuss the proteins that interact with these circular structures and that promote and regulate their formation, aiming to clarify the key features of genome circularization and understand how these affect the flaviviruses life cycle.This research was supported by Fundação para a Ciência e a Tecnologia—Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) and the Calouste Gulbenkian Foundation (FCG, Portugal) project Science Frontiers Research Prize 2010. N.M.S. acknowledges FCT-MCTES fellowship SFRH/BD/144585/2019. I.C.M. acknowledges FCT-MCTES program “Concurso de Estímulo ao Emprego Científico” (CEECIND/01670/2017).MDPIRepositório da Universidade de LisboaDe Falco, LouisSilva, NellySantos, Nuno C.Huber, Roland G.Martins, Ivo C.2021-09-16T13:18:39Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49529engCells. 2021 Mar 13;10(3):64210.3390/cells100306422073-4409info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:22Zoai:repositorio.ul.pt:10451/49529Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:09.165795Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
title The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
spellingShingle The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
De Falco, Louis
RNA structure
Circular RNA
Circular genomes
Flavivirus
Virus genomes
title_short The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
title_full The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
title_fullStr The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
title_full_unstemmed The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
title_sort The pseudo-circular genomes of Flaviviruses: structures, mechanisms, and functions of circularization
author De Falco, Louis
author_facet De Falco, Louis
Silva, Nelly
Santos, Nuno C.
Huber, Roland G.
Martins, Ivo C.
author_role author
author2 Silva, Nelly
Santos, Nuno C.
Huber, Roland G.
Martins, Ivo C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv De Falco, Louis
Silva, Nelly
Santos, Nuno C.
Huber, Roland G.
Martins, Ivo C.
dc.subject.por.fl_str_mv RNA structure
Circular RNA
Circular genomes
Flavivirus
Virus genomes
topic RNA structure
Circular RNA
Circular genomes
Flavivirus
Virus genomes
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-09-16T13:18:39Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49529
url http://hdl.handle.net/10451/49529
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cells. 2021 Mar 13;10(3):642
10.3390/cells10030642
2073-4409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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