Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/6494 |
Resumo: | The authors are grateful to the participants of the study, the study team in Nicaragua for sample collection and preparation and all those who contributed with ideas and the analyses of samples, Kate Jones, Elizabeth Leese, James Staff, Howard Mason and Shahwaiz Iqbal from HSE, Buxton, UK, Moosa Faniband from Lund University, Sweden, and Kristina Jakobsson from University of Gothenburg, Sweden. |
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Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathyChronic Kidney Disease of Unknown Origin (CKDu)Environmental ToxinsMesoamerican Nephropathy (MeN)NephrotoxicityPesticidesSegurança AlimentarAvaliação de RiscoToxicologiaSaúde HumanaThe authors are grateful to the participants of the study, the study team in Nicaragua for sample collection and preparation and all those who contributed with ideas and the analyses of samples, Kate Jones, Elizabeth Leese, James Staff, Howard Mason and Shahwaiz Iqbal from HSE, Buxton, UK, Moosa Faniband from Lund University, Sweden, and Kristina Jakobsson from University of Gothenburg, Sweden.Objectives: There is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years. Methods: Urine samples collected at baseline (pre-sugarcane harvest) and the first 6 month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (aluminium, total arsenic, cadmium, chromium, cobalt, copper, lead, manganese, mercury, selenium, silicon and strontium) were analysed by inductively coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-dichlorophenoxyacetic acid, 3-phenoxybenzoic acid, 4-fluoro-3-phenoxybenzoic acid, chloro-3,3,3-trifluoro-1-propen-1-yl-2,2-dimethylcyclopropanecarboxylic acid, cis/trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, ethylenethiourea, glyphosate, 4-chloro-2-methylphenoxy acetic acid, 3-hydroxy-pyrimetanil, 5-hydroxytiabendazole, hydroxy-tebuconazole and 3,5,6-trichloro-2-pyridinol) and two mycotoxins (ochratoxin A (OTA) and citrinin (CIT)) were analysed by liquid chromatography coupled-mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable vs declining kidney function) were examined. Results: Elevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection. Conclusions: The tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.This study was supported by the Colt Foundation (Grant number CF/03/14 and through a PhD fellowship awarded to ETS). Additional support was received from the Dutch National Postcode Lottery providing additional funding through Solidaridad. Thanks are due for the financial support to CESAM (UID/AMB/50017/2019), to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020.BMJ Publishing Group/ Royal College of Physicians of London, Faculty of Occupational MedicineRepositório Científico do Instituto Nacional de SaúdeSmpokou, Evangelia-TheanoGonzález-Quiroz, MarvinMartins, CarlaAlvito, PaulaLe Blond, JenniferGlaser, JasonAragón, AuroraWesseling, CatharinaNitsch, DorotheaPearce, NeilNorman, JillLindh, ChristianMorton, JackieCaplin, Ben2020-04-23T15:57:47Z2019-09-272019-09-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6494engOccup Environ Med . 2019 Dec;76(12):920-926. doi: 10.1136/oemed-2019-105772. Epub 2019 Sep 271351-071110.1136/oemed-2019-105772info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:29Zoai:repositorio.insa.pt:10400.18/6494Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:12.152026Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| title |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| spellingShingle |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy Smpokou, Evangelia-Theano Chronic Kidney Disease of Unknown Origin (CKDu) Environmental Toxins Mesoamerican Nephropathy (MeN) Nephrotoxicity Pesticides Segurança Alimentar Avaliação de Risco Toxicologia Saúde Humana |
| title_short |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| title_full |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| title_fullStr |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| title_full_unstemmed |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| title_sort |
Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy |
| author |
Smpokou, Evangelia-Theano |
| author_facet |
Smpokou, Evangelia-Theano González-Quiroz, Marvin Martins, Carla Alvito, Paula Le Blond, Jennifer Glaser, Jason Aragón, Aurora Wesseling, Catharina Nitsch, Dorothea Pearce, Neil Norman, Jill Lindh, Christian Morton, Jackie Caplin, Ben |
| author_role |
author |
| author2 |
González-Quiroz, Marvin Martins, Carla Alvito, Paula Le Blond, Jennifer Glaser, Jason Aragón, Aurora Wesseling, Catharina Nitsch, Dorothea Pearce, Neil Norman, Jill Lindh, Christian Morton, Jackie Caplin, Ben |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Smpokou, Evangelia-Theano González-Quiroz, Marvin Martins, Carla Alvito, Paula Le Blond, Jennifer Glaser, Jason Aragón, Aurora Wesseling, Catharina Nitsch, Dorothea Pearce, Neil Norman, Jill Lindh, Christian Morton, Jackie Caplin, Ben |
| dc.subject.por.fl_str_mv |
Chronic Kidney Disease of Unknown Origin (CKDu) Environmental Toxins Mesoamerican Nephropathy (MeN) Nephrotoxicity Pesticides Segurança Alimentar Avaliação de Risco Toxicologia Saúde Humana |
| topic |
Chronic Kidney Disease of Unknown Origin (CKDu) Environmental Toxins Mesoamerican Nephropathy (MeN) Nephrotoxicity Pesticides Segurança Alimentar Avaliação de Risco Toxicologia Saúde Humana |
| description |
The authors are grateful to the participants of the study, the study team in Nicaragua for sample collection and preparation and all those who contributed with ideas and the analyses of samples, Kate Jones, Elizabeth Leese, James Staff, Howard Mason and Shahwaiz Iqbal from HSE, Buxton, UK, Moosa Faniband from Lund University, Sweden, and Kristina Jakobsson from University of Gothenburg, Sweden. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-09-27 2019-09-27T00:00:00Z 2020-04-23T15:57:47Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6494 |
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http://hdl.handle.net/10400.18/6494 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Occup Environ Med . 2019 Dec;76(12):920-926. doi: 10.1136/oemed-2019-105772. Epub 2019 Sep 27 1351-0711 10.1136/oemed-2019-105772 |
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embargoedAccess |
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application/pdf |
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BMJ Publishing Group/ Royal College of Physicians of London, Faculty of Occupational Medicine |
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BMJ Publishing Group/ Royal College of Physicians of London, Faculty of Occupational Medicine |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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