Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012

Detalhes bibliográficos
Autor(a) principal: Amaral, Rita
Data de Publicação: 2018
Outros Autores: Fonseca, João A., Jacinto, Tiago, Pereira, Ana M., Malinovschi, Andrei, Janson, Christer, Alving, Kjell
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/13743
Resumo: Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Data from the National Health and Nutrition Examination Surveys (NHANES) 2007–2012 were used (n = 30,442). Adults with current asthma were selected. Asthma phenotypes were: B-Eos-high [if blood eosinophils (B-Eos) ≥ 300/mm3]; FeNO-high (FeNO ≥ 35 ppb); B-Eos&FeNO-low (B-Eos < 150/mm3 and FeNO < 20 ppb); asthma with obesity (AwObesity) (BMI ≥ 30 kg/m2); and asthma with concurrent COPD. Data were weighted for the US population and analyses were stratified by age (< 40 and ≥ 40 years old). Of the 18,619 adults included, 1059 (5.6% [95% CI 5.1–5.9]) had current asthma. A substantial overlap was observed both in subjects aged < 40 years (44%) and ≥ 40 years (54%). The more prevalent specific overlaps in both age groups were AwObesity associated with either B-Eos-high (15 and 12%, respectively) or B-Eos&FeNO-low asthma (13 and 11%, respectively). About 14% of the current asthma patients were “non-classified”. Regardless of phenotype classification, having concomitant phenotypes was significantly associated with (adjusted OR, 95% CI) ≥ 2 controller medications (2.03, 1.16–3.57), and FEV1 < LLN (3.21, 1.74–5.94), adjusted for confounding variables. A prevalent overlap of commonly reported asthma phenotypes was observed among asthma patients from the general population, with implications for objective asthma outcomes. A broader approach may be required to better characterize asthma patients and prevent poor asthma outcomes.
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spelling Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012AsthmaEpidemiological studyOverlapPhenotypesEvidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Data from the National Health and Nutrition Examination Surveys (NHANES) 2007–2012 were used (n = 30,442). Adults with current asthma were selected. Asthma phenotypes were: B-Eos-high [if blood eosinophils (B-Eos) ≥ 300/mm3]; FeNO-high (FeNO ≥ 35 ppb); B-Eos&FeNO-low (B-Eos < 150/mm3 and FeNO < 20 ppb); asthma with obesity (AwObesity) (BMI ≥ 30 kg/m2); and asthma with concurrent COPD. Data were weighted for the US population and analyses were stratified by age (< 40 and ≥ 40 years old). Of the 18,619 adults included, 1059 (5.6% [95% CI 5.1–5.9]) had current asthma. A substantial overlap was observed both in subjects aged < 40 years (44%) and ≥ 40 years (54%). The more prevalent specific overlaps in both age groups were AwObesity associated with either B-Eos-high (15 and 12%, respectively) or B-Eos&FeNO-low asthma (13 and 11%, respectively). About 14% of the current asthma patients were “non-classified”. Regardless of phenotype classification, having concomitant phenotypes was significantly associated with (adjusted OR, 95% CI) ≥ 2 controller medications (2.03, 1.16–3.57), and FEV1 < LLN (3.21, 1.74–5.94), adjusted for confounding variables. A prevalent overlap of commonly reported asthma phenotypes was observed among asthma patients from the general population, with implications for objective asthma outcomes. A broader approach may be required to better characterize asthma patients and prevent poor asthma outcomes.Repositório Científico do Instituto Politécnico do PortoAmaral, RitaFonseca, João A.Jacinto, TiagoPereira, Ana M.Malinovschi, AndreiJanson, ChristerAlving, Kjell2019-05-20T12:08:39Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/13743engAmaral, R., Fonseca, J. A., Jacinto, T., Pereira, A. M., Malinovschi, A., Janson, C., & Alving, K. (2018). Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007-2012. Clinical and Translational Allergy, 8(1), 13. https://doi.org/10.1186/s13601-018-0201-32045-702210.1186/s13601-018-0201-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-20T01:53:13Zoai:recipp.ipp.pt:10400.22/13743Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:33:36.756701Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
title Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
spellingShingle Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
Amaral, Rita
Asthma
Epidemiological study
Overlap
Phenotypes
title_short Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
title_full Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
title_fullStr Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
title_full_unstemmed Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
title_sort Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012
author Amaral, Rita
author_facet Amaral, Rita
Fonseca, João A.
Jacinto, Tiago
Pereira, Ana M.
Malinovschi, Andrei
Janson, Christer
Alving, Kjell
author_role author
author2 Fonseca, João A.
Jacinto, Tiago
Pereira, Ana M.
Malinovschi, Andrei
Janson, Christer
Alving, Kjell
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Amaral, Rita
Fonseca, João A.
Jacinto, Tiago
Pereira, Ana M.
Malinovschi, Andrei
Janson, Christer
Alving, Kjell
dc.subject.por.fl_str_mv Asthma
Epidemiological study
Overlap
Phenotypes
topic Asthma
Epidemiological study
Overlap
Phenotypes
description Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Data from the National Health and Nutrition Examination Surveys (NHANES) 2007–2012 were used (n = 30,442). Adults with current asthma were selected. Asthma phenotypes were: B-Eos-high [if blood eosinophils (B-Eos) ≥ 300/mm3]; FeNO-high (FeNO ≥ 35 ppb); B-Eos&FeNO-low (B-Eos < 150/mm3 and FeNO < 20 ppb); asthma with obesity (AwObesity) (BMI ≥ 30 kg/m2); and asthma with concurrent COPD. Data were weighted for the US population and analyses were stratified by age (< 40 and ≥ 40 years old). Of the 18,619 adults included, 1059 (5.6% [95% CI 5.1–5.9]) had current asthma. A substantial overlap was observed both in subjects aged < 40 years (44%) and ≥ 40 years (54%). The more prevalent specific overlaps in both age groups were AwObesity associated with either B-Eos-high (15 and 12%, respectively) or B-Eos&FeNO-low asthma (13 and 11%, respectively). About 14% of the current asthma patients were “non-classified”. Regardless of phenotype classification, having concomitant phenotypes was significantly associated with (adjusted OR, 95% CI) ≥ 2 controller medications (2.03, 1.16–3.57), and FEV1 < LLN (3.21, 1.74–5.94), adjusted for confounding variables. A prevalent overlap of commonly reported asthma phenotypes was observed among asthma patients from the general population, with implications for objective asthma outcomes. A broader approach may be required to better characterize asthma patients and prevent poor asthma outcomes.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-05-20T12:08:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/13743
url http://hdl.handle.net/10400.22/13743
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amaral, R., Fonseca, J. A., Jacinto, T., Pereira, A. M., Malinovschi, A., Janson, C., & Alving, K. (2018). Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007-2012. Clinical and Translational Allergy, 8(1), 13. https://doi.org/10.1186/s13601-018-0201-3
2045-7022
10.1186/s13601-018-0201-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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