Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/5049 https://doi.org/10.1016/j.jpba.2006.11.038 |
Resumo: | Flow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10-7 to 5.0 × 10-4 mol L-1) in phosphate buffer solution as well as high sensitivity (0.143 A mol-1 L cm-2) and low submicromolar detection limit (1.36 × 10-7 mol L-1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10-6 and 5.0 × 10-5 mol L-1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements. |
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Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulationsFlow injection analysisCarbon film resistor electrodesAcetaminophenAmperometryFlow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10-7 to 5.0 × 10-4 mol L-1) in phosphate buffer solution as well as high sensitivity (0.143 A mol-1 L cm-2) and low submicromolar detection limit (1.36 × 10-7 mol L-1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10-6 and 5.0 × 10-5 mol L-1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements.http://www.sciencedirect.com/science/article/B6TGX-4MSHT96-1/1/a5eb87f817e43c4bd0120021afa851f32007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5049http://hdl.handle.net/10316/5049https://doi.org/10.1016/j.jpba.2006.11.038engJournal of Pharmaceutical and Biomedical Analysis. 43:5 (2007) 1622-1627Felix, Fabiana S.Brett, Christopher M. A.Angnes, Lúcioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-07-27T09:45:26Zoai:estudogeral.uc.pt:10316/5049Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:01:16.501349Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
title |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
spellingShingle |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations Felix, Fabiana S. Flow injection analysis Carbon film resistor electrodes Acetaminophen Amperometry |
title_short |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
title_full |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
title_fullStr |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
title_full_unstemmed |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
title_sort |
Carbon film resistor electrode for amperometric determination of acetaminophen in pharmaceutical formulations |
author |
Felix, Fabiana S. |
author_facet |
Felix, Fabiana S. Brett, Christopher M. A. Angnes, Lúcio |
author_role |
author |
author2 |
Brett, Christopher M. A. Angnes, Lúcio |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Felix, Fabiana S. Brett, Christopher M. A. Angnes, Lúcio |
dc.subject.por.fl_str_mv |
Flow injection analysis Carbon film resistor electrodes Acetaminophen Amperometry |
topic |
Flow injection analysis Carbon film resistor electrodes Acetaminophen Amperometry |
description |
Flow injection analysis (FIA) with amperometric detection was employed for acetaminophen quantification in pharmaceutical formulations using a carbon film resistor electrode. This sensor exhibited sharp and reproducible current peaks for acetaminophen without chemical modification of its surface. A wide linear working range (8.0 × 10-7 to 5.0 × 10-4 mol L-1) in phosphate buffer solution as well as high sensitivity (0.143 A mol-1 L cm-2) and low submicromolar detection limit (1.36 × 10-7 mol L-1) were achieved. The repeatability (R.S.D. for 10 successive injections of 5.0 × 10-6 and 5.0 × 10-5 mol L-1 acetaminophen solutions) was 3.1 and 1.3%, respectively, without any memory effect between injections. The new procedure was applied to the analyses of commercial pharmaceutical products and the results were in good agreement with those obtained utilizing a spectrophotometric method. Consequently, this amperometric method has been shown to be very suitable for quality control analyses and other applications with similar requirements. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/5049 http://hdl.handle.net/10316/5049 https://doi.org/10.1016/j.jpba.2006.11.038 |
url |
http://hdl.handle.net/10316/5049 https://doi.org/10.1016/j.jpba.2006.11.038 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Pharmaceutical and Biomedical Analysis. 43:5 (2007) 1622-1627 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
aplication/PDF |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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