Natural compounds as metabolic modulators of the tumor microenvironment
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/37940 |
Resumo: | The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to '(re)-educate' TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression. |
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Natural compounds as metabolic modulators of the tumor microenvironmentTumor microenvironmentStromal cellsMetabolismMetabolic modulationNatural compoundsPhytochemicalsCancerThe tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to '(re)-educate' TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression.MDPI2023-06-06T09:34:21Z2021-06-08T00:00:00Z2021-06-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/37940eng10.3390/molecules26123494Dias, Ana S.Helguero, LuisaAlmeida, Catarina R.Duarte, Iola F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:11:53Zoai:ria.ua.pt:10773/37940Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:07:53.208615Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Natural compounds as metabolic modulators of the tumor microenvironment |
title |
Natural compounds as metabolic modulators of the tumor microenvironment |
spellingShingle |
Natural compounds as metabolic modulators of the tumor microenvironment Dias, Ana S. Tumor microenvironment Stromal cells Metabolism Metabolic modulation Natural compounds Phytochemicals Cancer |
title_short |
Natural compounds as metabolic modulators of the tumor microenvironment |
title_full |
Natural compounds as metabolic modulators of the tumor microenvironment |
title_fullStr |
Natural compounds as metabolic modulators of the tumor microenvironment |
title_full_unstemmed |
Natural compounds as metabolic modulators of the tumor microenvironment |
title_sort |
Natural compounds as metabolic modulators of the tumor microenvironment |
author |
Dias, Ana S. |
author_facet |
Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. |
author_role |
author |
author2 |
Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. |
dc.subject.por.fl_str_mv |
Tumor microenvironment Stromal cells Metabolism Metabolic modulation Natural compounds Phytochemicals Cancer |
topic |
Tumor microenvironment Stromal cells Metabolism Metabolic modulation Natural compounds Phytochemicals Cancer |
description |
The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to '(re)-educate' TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-08T00:00:00Z 2021-06-08 2023-06-06T09:34:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/37940 |
url |
http://hdl.handle.net/10773/37940 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3390/molecules26123494 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137732581130240 |