Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Daniel Barreira
Data de Publicação: 2024
Outros Autores: Reis, R. L., Pirraco, Rogério P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/88564
Resumo: Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cellâ cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.
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spelling Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool3D tumor modelsCancerSpheroidsTumor microenvironmentCancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cellâ cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.Authors would like to acknowledge the fnancial support from the European Research Council through the Starting Grant “CapBed” (ERC-2018-STG-805411) and FCT/MCTES (Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia, e Ensino Superior) through the grant SFRH/BD/119756/2016 (D.B.R.). The authors would additionally like to thank the contributions to this work from the project “TERM RES Hub—Scientifc Infrastructure for Tissue Engineering and Regenerative Medicine”, reference PINFRA/22190/2016 (Norte-01-0145-FEDER-022190), funded by the Portuguese National Science Foundation (FCT) in cooperation with the Northern Portugal Regional Coordination and Development Commission (CCDR-N). Ultimately, we would like to equally acknowledge fnancial support fromhttps://doi.org/10.54499/ UIDB/50026/2020);https://doi.org/10.54499/UIDP/50026/2020) andhttps://doi. org/10.54499/LA/P/0050/2020).BMCUniversidade do MinhoRodrigues, Daniel BarreiraReis, R. L.Pirraco, Rogério P.2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/88564engRodrigues D. B., Reis R. L., Pirraco R. P. Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool, Journal of Biomedical Science , doi:10.1186/s12929-024-00997-9, 20241021-77701423-012710.1186/s12929-024-00997-938254117https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-00997-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-24T01:23:49Zoai:repositorium.sdum.uminho.pt:1822/88564Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:37:06.311753Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
title Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
spellingShingle Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
Rodrigues, Daniel Barreira
3D tumor models
Cancer
Spheroids
Tumor microenvironment
title_short Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
title_full Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
title_fullStr Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
title_full_unstemmed Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
title_sort Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
author Rodrigues, Daniel Barreira
author_facet Rodrigues, Daniel Barreira
Reis, R. L.
Pirraco, Rogério P.
author_role author
author2 Reis, R. L.
Pirraco, Rogério P.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Daniel Barreira
Reis, R. L.
Pirraco, Rogério P.
dc.subject.por.fl_str_mv 3D tumor models
Cancer
Spheroids
Tumor microenvironment
topic 3D tumor models
Cancer
Spheroids
Tumor microenvironment
description Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cellâ cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/88564
url https://hdl.handle.net/1822/88564
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues D. B., Reis R. L., Pirraco R. P. Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool, Journal of Biomedical Science , doi:10.1186/s12929-024-00997-9, 2024
1021-7770
1423-0127
10.1186/s12929-024-00997-9
38254117
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-00997-9
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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