Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs

Detalhes bibliográficos
Autor(a) principal: Silva, Ana Teresa
Data de Publicação: 2019
Outros Autores: Bento, Clara M., Pena, Ana C, Figueiredo, Luisa M., Prudêncio, Cristina, Aguiar, Luísa, Silva, Tânia, Ferraz, Ricardo, Gomes, Maria Salomé, Teixeira, Cátia, Gomes, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50334
Resumo: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugsAmideAminoquinolineAntimalarialAntioxidantAntiparasiticAntiproliferativeArtemisininChloroquineCinnamicIonic liquidPrimaquineRepurposingRescuing© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.This research was funded by Fundação para a Ciência e Tecnologia (FCT), Portugal, grants UID/QUI/50006/2019, and PTDC/BTM-SAL/29786/2017.MDPIRepositório da Universidade de LisboaSilva, Ana TeresaBento, Clara M.Pena, Ana CFigueiredo, Luisa M.Prudêncio, CristinaAguiar, LuísaSilva, TâniaFerraz, RicardoGomes, Maria SaloméTeixeira, CátiaGomes, Paula2021-12-10T14:31:14Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50334engMolecules. 2019 Dec 24;25(1):6610.3390/molecules250100661420-3049info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:28Zoai:repositorio.ul.pt:10451/50334Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:49.034743Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
spellingShingle Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
Silva, Ana Teresa
Amide
Aminoquinoline
Antimalarial
Antioxidant
Antiparasitic
Antiproliferative
Artemisinin
Chloroquine
Cinnamic
Ionic liquid
Primaquine
Repurposing
Rescuing
title_short Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_full Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_fullStr Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_full_unstemmed Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_sort Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
author Silva, Ana Teresa
author_facet Silva, Ana Teresa
Bento, Clara M.
Pena, Ana C
Figueiredo, Luisa M.
Prudêncio, Cristina
Aguiar, Luísa
Silva, Tânia
Ferraz, Ricardo
Gomes, Maria Salomé
Teixeira, Cátia
Gomes, Paula
author_role author
author2 Bento, Clara M.
Pena, Ana C
Figueiredo, Luisa M.
Prudêncio, Cristina
Aguiar, Luísa
Silva, Tânia
Ferraz, Ricardo
Gomes, Maria Salomé
Teixeira, Cátia
Gomes, Paula
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Silva, Ana Teresa
Bento, Clara M.
Pena, Ana C
Figueiredo, Luisa M.
Prudêncio, Cristina
Aguiar, Luísa
Silva, Tânia
Ferraz, Ricardo
Gomes, Maria Salomé
Teixeira, Cátia
Gomes, Paula
dc.subject.por.fl_str_mv Amide
Aminoquinoline
Antimalarial
Antioxidant
Antiparasitic
Antiproliferative
Artemisinin
Chloroquine
Cinnamic
Ionic liquid
Primaquine
Repurposing
Rescuing
topic Amide
Aminoquinoline
Antimalarial
Antioxidant
Antiparasitic
Antiproliferative
Artemisinin
Chloroquine
Cinnamic
Ionic liquid
Primaquine
Repurposing
Rescuing
description © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-12-10T14:31:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50334
url http://hdl.handle.net/10451/50334
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Molecules. 2019 Dec 24;25(1):66
10.3390/molecules25010066
1420-3049
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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