Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs

Detalhes bibliográficos
Autor(a) principal: Silva, AT
Data de Publicação: 2020
Outros Autores: Bento, CM, Pena, AC, Figueiredo, LM, Prudêncio, C, Aguiar, L, Silva, T, Ferraz, R, Gomes, MS, Teixeira, C, Gomes, P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/141485
Resumo: Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.
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spelling Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugsCinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/141485eng1420-304910.3390/molecules25010066Silva, ATBento, CMPena, ACFigueiredo, LMPrudêncio, CAguiar, LSilva, TFerraz, RGomes, MSTeixeira, CGomes, Pinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T09:18:42Zoai:repositorio-aberto.up.pt:10216/141485Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T09:18:42Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
spellingShingle Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
Silva, AT
title_short Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_full Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_fullStr Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_full_unstemmed Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
title_sort Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs
author Silva, AT
author_facet Silva, AT
Bento, CM
Pena, AC
Figueiredo, LM
Prudêncio, C
Aguiar, L
Silva, T
Ferraz, R
Gomes, MS
Teixeira, C
Gomes, P
author_role author
author2 Bento, CM
Pena, AC
Figueiredo, LM
Prudêncio, C
Aguiar, L
Silva, T
Ferraz, R
Gomes, MS
Teixeira, C
Gomes, P
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, AT
Bento, CM
Pena, AC
Figueiredo, LM
Prudêncio, C
Aguiar, L
Silva, T
Ferraz, R
Gomes, MS
Teixeira, C
Gomes, P
description Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/141485
url https://hdl.handle.net/10216/141485
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
10.3390/molecules25010066
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dc.publisher.none.fl_str_mv MDPI
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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