Cilia distal domain: diversity in evolutionarily conserved structures

Detalhes bibliográficos
Autor(a) principal: Soares, Helena
Data de Publicação: 2019
Outros Autores: Carmona, Bruno, Nolasco, Sofia, Melo, Luís Viseu, Gonçalves, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/9520
Resumo: FCT_UID/Multi/00612; IPL/2016/TBCCentro_ESTeSL; IPL/2017/CILIOPAT_ESTeSL.
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spelling Cilia distal domain: diversity in evolutionarily conserved structuresCiliaCilia distal domainMicrotubule-capping structuresCilia structural diversityFCT_UID/Multi/00612IPL/2016/TBCCentro_ESTeSLIPL/2017/CILIOPAT_ESTeSLFCT_UID/Multi/00612; IPL/2016/TBCCentro_ESTeSL; IPL/2017/CILIOPAT_ESTeSL.Eukaryotic cilia are microtubule-based organelles that protrude from the cell surface to fulfill sensory and motility functions. Their basic structure consists of an axoneme templated by a centriole/basal body. Striking differences in ciliary ultra-structures can be found at the ciliary base, the axoneme and the tip, not only throughout the eukaryotic tree of life, but within a single organism. Defects in cilia biogenesis and function are at the origin of human ciliopathies. This structural/functional diversity and its relationship with the etiology of these diseases is poorly understood. Some of the important events in cilia function occur at their distal domain, including cilia assembly/disassembly, IFT (intraflagellar transport) complexes' remodeling, and signal detection/transduction. How axonemal microtubules end at this domain varies with distinct cilia types, originating different tip architectures. Additionally, they show a high degree of dynamic behavior and are able to respond to different stimuli. The existence of microtubule-capping structures (caps) in certain types of cilia contributes to this diversity. It has been proposed that caps play a role in axoneme length control and stabilization, but their roles are still poorly understood. Here, we review the current knowledge on cilia structure diversity with a focus on the cilia distal domain and caps and discuss how they affect cilia structure and function.MDPIRCIPLSoares, HelenaCarmona, BrunoNolasco, SofiaMelo, Luís ViseuGonçalves, João2019-02-18T15:54:35Z2019-022019-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/9520engSoares H, Carmona B, Nolasco S, Melo LV, Gonçalves J. Cilia distal domain: diversity in evolutionarily conserved structures. Cells. 2019;8(2):160.10.3390/cells8020160info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:58:17Zoai:repositorio.ipl.pt:10400.21/9520Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:18:04.747710Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cilia distal domain: diversity in evolutionarily conserved structures
title Cilia distal domain: diversity in evolutionarily conserved structures
spellingShingle Cilia distal domain: diversity in evolutionarily conserved structures
Soares, Helena
Cilia
Cilia distal domain
Microtubule-capping structures
Cilia structural diversity
FCT_UID/Multi/00612
IPL/2016/TBCCentro_ESTeSL
IPL/2017/CILIOPAT_ESTeSL
title_short Cilia distal domain: diversity in evolutionarily conserved structures
title_full Cilia distal domain: diversity in evolutionarily conserved structures
title_fullStr Cilia distal domain: diversity in evolutionarily conserved structures
title_full_unstemmed Cilia distal domain: diversity in evolutionarily conserved structures
title_sort Cilia distal domain: diversity in evolutionarily conserved structures
author Soares, Helena
author_facet Soares, Helena
Carmona, Bruno
Nolasco, Sofia
Melo, Luís Viseu
Gonçalves, João
author_role author
author2 Carmona, Bruno
Nolasco, Sofia
Melo, Luís Viseu
Gonçalves, João
author2_role author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Soares, Helena
Carmona, Bruno
Nolasco, Sofia
Melo, Luís Viseu
Gonçalves, João
dc.subject.por.fl_str_mv Cilia
Cilia distal domain
Microtubule-capping structures
Cilia structural diversity
FCT_UID/Multi/00612
IPL/2016/TBCCentro_ESTeSL
IPL/2017/CILIOPAT_ESTeSL
topic Cilia
Cilia distal domain
Microtubule-capping structures
Cilia structural diversity
FCT_UID/Multi/00612
IPL/2016/TBCCentro_ESTeSL
IPL/2017/CILIOPAT_ESTeSL
description FCT_UID/Multi/00612; IPL/2016/TBCCentro_ESTeSL; IPL/2017/CILIOPAT_ESTeSL.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-18T15:54:35Z
2019-02
2019-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/9520
url http://hdl.handle.net/10400.21/9520
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Soares H, Carmona B, Nolasco S, Melo LV, Gonçalves J. Cilia distal domain: diversity in evolutionarily conserved structures. Cells. 2019;8(2):160.
10.3390/cells8020160
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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