Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties

Detalhes bibliográficos
Autor(a) principal: Justino, Jorge
Data de Publicação: 2012
Outros Autores: Rauter, Amélia, Dias, Catarina, Martins, Alice, Branco, Isabel, Goulart, Margarida, Nogueira, José, Neng, Nuno, Silva, Filipa, Trevitt, Clare, Waltho, Jon
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.15/882
Resumo: Estudo de produção agronómica de espécis da salvia com vista à avaliação dos seus constituintes para o potencial controlo da doença de Alzaimer
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spelling Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding propertiesSalvia sclareoidesPhenolic profileAntioxidant activityCytotoxicityGenotoxicityPrion bindingEstudo de produção agronómica de espécis da salvia com vista à avaliação dos seus constituintes para o potencial controlo da doença de AlzaimerSalvia sclareoides is an aromatic herb native to Portugal, of which phenolic content (Folin–Ciocalteau method), chemical profile (HPLC/DAD), antioxidant activity (DPPH, β-carotene/linoleic acid assays), acute toxicity (MTT method, adapted for non-adherent cells), genotoxicity (short-term chromosomal aberration assay) and prion binding properties were evaluated in the acetone, water, ethanol, methanol and n-butanol extracts. The latter presented the highest phenolic content and antioxidant activity (DPPH assay), and was the single one with the flavonoids (+)-catechin, kaempferol O-glucoside and quercetin. Vanillic acid was the major component of all extracts but gallic, gentisic, caffeic, syringic, coumaric and ferulic acids were also found in some extracts. Only the n-butanol extract had components binding to the cellular form of human prion protein detected by NMR which showed specificity for two regions of the folded domain and for the unstructured N-terminal region. Extracts were not cytotoxic nor genotoxic, reinforcing the potential of S. sclareoides for nutraceutical purposes.Este trabalho é financiado por Fundos FEDER através do Programa Operacional Fatores de Competitividade – COMPETE e por Fundos Nacionais através da FCT – Fundação para a Ciência e a Tecnologia no âmbito do projeto «Refª do Projecto»ElsevierRepositório Científico do Instituto Politécnico de SantarémJustino, JorgeRauter, AméliaDias, CatarinaMartins, AliceBranco, IsabelGoulart, MargaridaNogueira, JoséNeng, NunoSilva, FilipaTrevitt, ClareWaltho, Jon2013-12-09T16:10:42Z2012-062012-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.15/882porJustino,J.;Rauter,A.;Dias,C.;Martins.A.;Branco,I.;Goulart,M. (2012).Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties.Food Chemistry,132,1930-1935. Disponível em : http://www.sciencedirect.com/science/article/pii/S03088146110178330308-8146info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-21T07:30:03Zoai:repositorio.ipsantarem.pt:10400.15/882Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:53:21.235270Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
title Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
spellingShingle Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
Justino, Jorge
Salvia sclareoides
Phenolic profile
Antioxidant activity
Cytotoxicity
Genotoxicity
Prion binding
title_short Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
title_full Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
title_fullStr Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
title_full_unstemmed Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
title_sort Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties
author Justino, Jorge
author_facet Justino, Jorge
Rauter, Amélia
Dias, Catarina
Martins, Alice
Branco, Isabel
Goulart, Margarida
Nogueira, José
Neng, Nuno
Silva, Filipa
Trevitt, Clare
Waltho, Jon
author_role author
author2 Rauter, Amélia
Dias, Catarina
Martins, Alice
Branco, Isabel
Goulart, Margarida
Nogueira, José
Neng, Nuno
Silva, Filipa
Trevitt, Clare
Waltho, Jon
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Santarém
dc.contributor.author.fl_str_mv Justino, Jorge
Rauter, Amélia
Dias, Catarina
Martins, Alice
Branco, Isabel
Goulart, Margarida
Nogueira, José
Neng, Nuno
Silva, Filipa
Trevitt, Clare
Waltho, Jon
dc.subject.por.fl_str_mv Salvia sclareoides
Phenolic profile
Antioxidant activity
Cytotoxicity
Genotoxicity
Prion binding
topic Salvia sclareoides
Phenolic profile
Antioxidant activity
Cytotoxicity
Genotoxicity
Prion binding
description Estudo de produção agronómica de espécis da salvia com vista à avaliação dos seus constituintes para o potencial controlo da doença de Alzaimer
publishDate 2012
dc.date.none.fl_str_mv 2012-06
2012-06-01T00:00:00Z
2013-12-09T16:10:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.15/882
url http://hdl.handle.net/10400.15/882
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Justino,J.;Rauter,A.;Dias,C.;Martins.A.;Branco,I.;Goulart,M. (2012).Non-toxic Salvia sclareoides Brot. extracts as a source of functional food ingredients: Phenolic profile, antioxidant activity and prion binding properties.Food Chemistry,132,1930-1935. Disponível em : http://www.sciencedirect.com/science/article/pii/S0308814611017833
0308-8146
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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