Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/18755 |
Resumo: | In the present study, aqueous extracts of Salvia africana, Salvia o cinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 7.5 g/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. o cinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple ca eic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of -carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC50 values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC50 = 47.8 2.1 g/mL). In addition, the three sage aqueous extracts showed promising cytotoxic e ect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries. |
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Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous ExtractsAnti-inflammatoryAntibacterialAntioxidantCytotoxicityHigh performance liquid chromatographyPhenolic compoundsSalviaIn the present study, aqueous extracts of Salvia africana, Salvia o cinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 7.5 g/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. o cinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple ca eic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of -carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC50 values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC50 = 47.8 2.1 g/mL). In addition, the three sage aqueous extracts showed promising cytotoxic e ect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries.Foundation for Science and Technology (FCT), the European Union, the National Strategic Reference Framework (QREN), the European Regional Development Fund (FEDER), and Operational Programme Competitiveness Factors (COMPETE), for funding the Organic Chemistry Research Unit (QOPNA) (FCT UID/QUI/00062/2019) and Mountain Research Center (CIMO) (UID/AGR/00690/2019), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement. A. Fernandes and R. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract. Project AgroForWealth (CENTRO-01–0145-FEDER-000001), funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso. APC was sponsored by MDPI.Biblioteca Digital do IPBAfonso, Andrea Luísa FernandesPereira, Olívia R.Fernandes, ÂngelaCalhelha, Ricardo C.Silva, ArturFerreira, Isabel C.F.R.Cardoso, Susana M.2018-01-19T10:00:00Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/18755engAfonso, Andrea F.; Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur M.S.; Ferreira, R. C.F.; Cardoso, Susana M. (2019). Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts. Molecules. ISSN 1420-3049. 24, p. 1-1310.3390/molecules24234327info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:45:58Zoai:bibliotecadigital.ipb.pt:10198/18755Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:10:54.889534Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
title |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
spellingShingle |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts Afonso, Andrea Luísa Fernandes Anti-inflammatory Antibacterial Antioxidant Cytotoxicity High performance liquid chromatography Phenolic compounds Salvia |
title_short |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
title_full |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
title_fullStr |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
title_full_unstemmed |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
title_sort |
Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts |
author |
Afonso, Andrea Luísa Fernandes |
author_facet |
Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
author_role |
author |
author2 |
Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Afonso, Andrea Luísa Fernandes Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur Ferreira, Isabel C.F.R. Cardoso, Susana M. |
dc.subject.por.fl_str_mv |
Anti-inflammatory Antibacterial Antioxidant Cytotoxicity High performance liquid chromatography Phenolic compounds Salvia |
topic |
Anti-inflammatory Antibacterial Antioxidant Cytotoxicity High performance liquid chromatography Phenolic compounds Salvia |
description |
In the present study, aqueous extracts of Salvia africana, Salvia o cinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 7.5 g/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. o cinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple ca eic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of -carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC50 values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC50 = 47.8 2.1 g/mL). In addition, the three sage aqueous extracts showed promising cytotoxic e ect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2019 2019-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/18755 |
url |
http://hdl.handle.net/10198/18755 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Afonso, Andrea F.; Pereira, Olívia R.; Fernandes, Ângela; Calhelha, Ricardo C.; Silva, Artur M.S.; Ferreira, R. C.F.; Cardoso, Susana M. (2019). Phytochemical composition and bioactive effects of Salvia africana, salvia officinalis 'Icterina' and Salvia mexicana aqueous Extracts. Molecules. ISSN 1420-3049. 24, p. 1-13 10.3390/molecules24234327 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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