Idiopathic nodular glomerulosclerosis: a case report

Detalhes bibliográficos
Autor(a) principal: Cunha,Catia
Data de Publicação: 2015
Outros Autores: Gomes,Ana Marta, Lopes,Daniela, Sousa,Sonia, Pereira,Susana, Campelos,Sofia, Tente,David, Fernandes,Joao Carlos
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000400011
Resumo: The histological pattern of nodular glomerulosclerosis is typical of diabetic nephropathy, but it can be found in other diseases, such as chronic membranoproliferative glomerulonephritis, amyloidosis, monoclonal immunoglobulin deposition and fibrillary/immunotactoid glomerulopathies. Additionally, there are few reports of idiopathic nodular glomerulosclerosis, an exclusion diagnosis, which has been associated with smoking. Herein we present a case of a non-diabetic 45-year-old man, with a background history of hypertension known for 5 years and heavy smoking, who was referred to our Nephrology clinic for evaluation of haematoproteinuria. Renal function was normal and serologies and immunoelectrophoresis studies were negative. Renal biopsy revealed a nodular glomerulosclerosis pattern on light microscopy, and immunofluorescence and electronic microscopy excluded other previously referred causes for this pattern. By exclusion, a diagnosis of idiopathicnodular glomerulosclerosis was established, probably in association with smoking and hypertension. Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity that should be considered in patients with active smoking, especially if there is concomitant hypertension. Some authors actually suggest the designation of “smoking -related nodular glomerulosclerosis” to this “pseudodiabetic” glomerulopathy.
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spelling Idiopathic nodular glomerulosclerosis: a case reportHypertensionnodular glomerulosclerosissmokingThe histological pattern of nodular glomerulosclerosis is typical of diabetic nephropathy, but it can be found in other diseases, such as chronic membranoproliferative glomerulonephritis, amyloidosis, monoclonal immunoglobulin deposition and fibrillary/immunotactoid glomerulopathies. Additionally, there are few reports of idiopathic nodular glomerulosclerosis, an exclusion diagnosis, which has been associated with smoking. Herein we present a case of a non-diabetic 45-year-old man, with a background history of hypertension known for 5 years and heavy smoking, who was referred to our Nephrology clinic for evaluation of haematoproteinuria. Renal function was normal and serologies and immunoelectrophoresis studies were negative. Renal biopsy revealed a nodular glomerulosclerosis pattern on light microscopy, and immunofluorescence and electronic microscopy excluded other previously referred causes for this pattern. By exclusion, a diagnosis of idiopathicnodular glomerulosclerosis was established, probably in association with smoking and hypertension. Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity that should be considered in patients with active smoking, especially if there is concomitant hypertension. Some authors actually suggest the designation of “smoking -related nodular glomerulosclerosis” to this “pseudodiabetic” glomerulopathy.Sociedade Portuguesa de Nefrologia2015-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000400011Portuguese Journal of Nephrology & Hypertension v.29 n.4 2015reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000400011Cunha,CatiaGomes,Ana MartaLopes,DanielaSousa,SoniaPereira,SusanaCampelos,SofiaTente,DavidFernandes,Joao Carlosinfo:eu-repo/semantics/openAccess2024-02-06T17:04:51Zoai:scielo:S0872-01692015000400011Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:55.853269Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Idiopathic nodular glomerulosclerosis: a case report
title Idiopathic nodular glomerulosclerosis: a case report
spellingShingle Idiopathic nodular glomerulosclerosis: a case report
Cunha,Catia
Hypertension
nodular glomerulosclerosis
smoking
title_short Idiopathic nodular glomerulosclerosis: a case report
title_full Idiopathic nodular glomerulosclerosis: a case report
title_fullStr Idiopathic nodular glomerulosclerosis: a case report
title_full_unstemmed Idiopathic nodular glomerulosclerosis: a case report
title_sort Idiopathic nodular glomerulosclerosis: a case report
author Cunha,Catia
author_facet Cunha,Catia
Gomes,Ana Marta
Lopes,Daniela
Sousa,Sonia
Pereira,Susana
Campelos,Sofia
Tente,David
Fernandes,Joao Carlos
author_role author
author2 Gomes,Ana Marta
Lopes,Daniela
Sousa,Sonia
Pereira,Susana
Campelos,Sofia
Tente,David
Fernandes,Joao Carlos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha,Catia
Gomes,Ana Marta
Lopes,Daniela
Sousa,Sonia
Pereira,Susana
Campelos,Sofia
Tente,David
Fernandes,Joao Carlos
dc.subject.por.fl_str_mv Hypertension
nodular glomerulosclerosis
smoking
topic Hypertension
nodular glomerulosclerosis
smoking
description The histological pattern of nodular glomerulosclerosis is typical of diabetic nephropathy, but it can be found in other diseases, such as chronic membranoproliferative glomerulonephritis, amyloidosis, monoclonal immunoglobulin deposition and fibrillary/immunotactoid glomerulopathies. Additionally, there are few reports of idiopathic nodular glomerulosclerosis, an exclusion diagnosis, which has been associated with smoking. Herein we present a case of a non-diabetic 45-year-old man, with a background history of hypertension known for 5 years and heavy smoking, who was referred to our Nephrology clinic for evaluation of haematoproteinuria. Renal function was normal and serologies and immunoelectrophoresis studies were negative. Renal biopsy revealed a nodular glomerulosclerosis pattern on light microscopy, and immunofluorescence and electronic microscopy excluded other previously referred causes for this pattern. By exclusion, a diagnosis of idiopathicnodular glomerulosclerosis was established, probably in association with smoking and hypertension. Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity that should be considered in patients with active smoking, especially if there is concomitant hypertension. Some authors actually suggest the designation of “smoking -related nodular glomerulosclerosis” to this “pseudodiabetic” glomerulopathy.
publishDate 2015
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.29 n.4 2015
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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