Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma.
| Autor(a) principal: | |
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| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/50201 |
Resumo: | non-edited manuscript |
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Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma.Human PapillomavirusRisk FactorsCancer EpidemiologyEsophageal cancerEsophageal NeoplasmsCiências Médicas::Medicina BásicaScience & Technologynon-edited manuscriptThe first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patients with and without esophageal squamous cell carcinoma (ESCC) and correlate HPV presence with classical risk factors. METHODS: Invited patients signed the informed consent form, and interviews were conducted in order to obtain information about sociodemographic and lifestyle behavior. During endoscopy, esophageal biopsies were collected from case and controls. Multiplex polymerase chain reaction genotyping was conducted on endoscopic biopsies to identify HPV types and HPV-16 was further evaluated by specific PCR real time. RESULTS: Among 87 cases, 12 (13.8%) had tumors harboring high risk HPV DNA and among 87 controls, 12 (13.8%) had high risk HPV DNA (OR:1.025 [CI:0.405:2.592]). Variables regarding consumption of alcohol and use of tobacco continued to characterize risk factors even after adjustments by presence or absence of high risk HPV. CONCLUSION: HPV was demonstrated to be frequently and similarly associated to normal and malignant esophageal tissues, but not as an independent risk factor to esophageal cancer. IMPACT: To contribute to the Brazilian population data on this subject, which is still contradictory.CNPq Universal for providing supplies to the largest study, of which this study is a part of, entitled “The role of human papillomavirus (HPV) as the etiologic agent of esophageal cancer. A cross-sectional study, case-control and longitudinal at Barretos Cancer Hospital”; (Grant number 482666/2012-9 to ALF); INCT HPV [Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [Grant number 08/57889-1 to LLV]; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Grant number 573799/2008-3 to LLV)]info:eu-repo/semantics/acceptedVersionUniversidad de Murciaet. al.Universidade do MinhoCosta, Allini Mafra daFregnani, José Humberto Tavares GuerreiroPastrez, Paula Roberta AguiarMariano, Vânia SammartinoNeto, Cristovam ScapulatempoGuimarães, Denise PeixotoOliveira, Kelly Menezio Giordina deNeto, Said Abdala ZemiNunes, Emily MontosaLongatto, Adhemar20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/50201engda Costa, A. M., Fregnani, J. H. T. G., Pastrez, P. R. A., et. al. (2017). Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. Histol Histopathol, 119290213-39111699-584810.14670/HH-11-92928875493http://www.hh.um.es/Articles-Proofs/11-929-manuscript.pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:26Zoai:repositorium.sdum.uminho.pt:1822/50201Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:02:05.068184Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| title |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| spellingShingle |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. Costa, Allini Mafra da Human Papillomavirus Risk Factors Cancer Epidemiology Esophageal cancer Esophageal Neoplasms Ciências Médicas::Medicina Básica Science & Technology |
| title_short |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| title_full |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| title_fullStr |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| title_full_unstemmed |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| title_sort |
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. |
| author |
Costa, Allini Mafra da |
| author_facet |
Costa, Allini Mafra da Fregnani, José Humberto Tavares Guerreiro Pastrez, Paula Roberta Aguiar Mariano, Vânia Sammartino Neto, Cristovam Scapulatempo Guimarães, Denise Peixoto Oliveira, Kelly Menezio Giordina de Neto, Said Abdala Zemi Nunes, Emily Montosa Longatto, Adhemar |
| author_role |
author |
| author2 |
Fregnani, José Humberto Tavares Guerreiro Pastrez, Paula Roberta Aguiar Mariano, Vânia Sammartino Neto, Cristovam Scapulatempo Guimarães, Denise Peixoto Oliveira, Kelly Menezio Giordina de Neto, Said Abdala Zemi Nunes, Emily Montosa Longatto, Adhemar |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
et. al. Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Costa, Allini Mafra da Fregnani, José Humberto Tavares Guerreiro Pastrez, Paula Roberta Aguiar Mariano, Vânia Sammartino Neto, Cristovam Scapulatempo Guimarães, Denise Peixoto Oliveira, Kelly Menezio Giordina de Neto, Said Abdala Zemi Nunes, Emily Montosa Longatto, Adhemar |
| dc.subject.por.fl_str_mv |
Human Papillomavirus Risk Factors Cancer Epidemiology Esophageal cancer Esophageal Neoplasms Ciências Médicas::Medicina Básica Science & Technology |
| topic |
Human Papillomavirus Risk Factors Cancer Epidemiology Esophageal cancer Esophageal Neoplasms Ciências Médicas::Medicina Básica Science & Technology |
| description |
non-edited manuscript |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/50201 |
| url |
http://hdl.handle.net/1822/50201 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
da Costa, A. M., Fregnani, J. H. T. G., Pastrez, P. R. A., et. al. (2017). Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related to esophageal squamous cell carcinoma. Histol Histopathol, 11929 0213-3911 1699-5848 10.14670/HH-11-929 28875493 http://www.hh.um.es/Articles-Proofs/11-929-manuscript.pdf |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad de Murcia |
| publisher.none.fl_str_mv |
Universidad de Murcia |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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