Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/44890 |
Resumo: | © 2017 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial, and no modifications or adaptations are made. |
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Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patientsAlberta Stroke Program Early CT ScoreEEGEpilepsyOutcomeSeizuresStroke© 2017 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial, and no modifications or adaptations are made.Objective: Seizures and electroencephalographic (EEG) abnormalities have been associated with unfavorable stroke functional outcome. However, this association may depend on clinical and imaging stroke severity. We set out to analyze whether epileptic seizures and early EEG abnormalities are predictors of stroke outcome after adjustment for age and clinical/imaging infarct severity. Methods: A prospective study was made on consecutive and previously independent acute stroke patients with a National Institutes of Health Stroke Scale (NIHSS) score ≥ 4 on admission and an acute anterior circulation ischemic lesion on brain imaging. All patients underwent standardized clinical and diagnostic assessment during admission and after discharge, and were followed for 12 months. Video-EEG (<60 min) was performed in the first 72 h. The Alberta Stroke Program Early CT Score quantified middle cerebral artery infarct size. The outcomes in this study were an unfavorable functional outcome (modified Rankin Scale [mRS] ≥ 3) and death (mRS = 6) at discharge and 12 months after stroke. Results: Unfavorable outcome at discharge was independently associated with NIHSS score (p = 0.001), EEG background activity slowing (p < 0.001), and asymmetry (p < 0.001). Unfavorable outcome 1 year after stroke was independently associated with age (p = 0.001), NIHSS score (p < 0.001), remote symptomatic seizures (p = 0.046), EEG background activity slowing (p < 0.001), and asymmetry (p < 0.001). Death in the first year after stroke was independently associated with age (p = 0.028), NIHSS score (p = 0.001), acute symptomatic seizures (p = 0.015), and EEG suppression (p = 0.019). Significance: Acute symptomatic seizures were independent predictors of vital outcome and remote symptomatic seizures of functional outcome in the first year after stroke. Therefore, their recognition and prevention strategies may be clinically relevant. Early EEG abnormalities were independent predictors and comparable to age and early clinical/imaging infarct severity in stroke functional outcome discrimination, reflecting the concept that EEG is a sensitive and robust method in the functional assessment of the brain.This work was supported by the 2012 Research Grant in Cerebrovascular Diseases (C.B.; scientific promoter: Sociedade Portuguesa do AVC; sponsor: Tecnifar).John Wiley & Sons, Inc.Repositório da Universidade de LisboaBentes, CarlaPeralta, Ana RitaMartins, Hugo F GCasimiro, CarlosMorgado, CarlosFranco, Ana CatarinaViana, PedroFonseca, Ana CatarinaGeraldes, RuthCanhão, PatríciaMelo, Teresa Pinho ePaiva, TeresaFerro, José2020-11-16T16:31:38Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44890engEpilepsia Open. 2017;2(4):441-45210.1002/epi4.120752470-9239info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:00:35Zoai:repositorio.ul.pt:10451/44890Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:00:35Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| title |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| spellingShingle |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients Bentes, Carla Alberta Stroke Program Early CT Score EEG Epilepsy Outcome Seizures Stroke |
| title_short |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| title_full |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| title_fullStr |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| title_full_unstemmed |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| title_sort |
Seizures, electroencephalographic abnormalities, and outcome of ischemic stroke patients |
| author |
Bentes, Carla |
| author_facet |
Bentes, Carla Peralta, Ana Rita Martins, Hugo F G Casimiro, Carlos Morgado, Carlos Franco, Ana Catarina Viana, Pedro Fonseca, Ana Catarina Geraldes, Ruth Canhão, Patrícia Melo, Teresa Pinho e Paiva, Teresa Ferro, José |
| author_role |
author |
| author2 |
Peralta, Ana Rita Martins, Hugo F G Casimiro, Carlos Morgado, Carlos Franco, Ana Catarina Viana, Pedro Fonseca, Ana Catarina Geraldes, Ruth Canhão, Patrícia Melo, Teresa Pinho e Paiva, Teresa Ferro, José |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Bentes, Carla Peralta, Ana Rita Martins, Hugo F G Casimiro, Carlos Morgado, Carlos Franco, Ana Catarina Viana, Pedro Fonseca, Ana Catarina Geraldes, Ruth Canhão, Patrícia Melo, Teresa Pinho e Paiva, Teresa Ferro, José |
| dc.subject.por.fl_str_mv |
Alberta Stroke Program Early CT Score EEG Epilepsy Outcome Seizures Stroke |
| topic |
Alberta Stroke Program Early CT Score EEG Epilepsy Outcome Seizures Stroke |
| description |
© 2017 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial, and no modifications or adaptations are made. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2020-11-16T16:31:38Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/44890 |
| url |
http://hdl.handle.net/10451/44890 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Epilepsia Open. 2017;2(4):441-452 10.1002/epi4.12075 2470-9239 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
| publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817549108970258432 |