Evaluation of pulmonary systemic blood flow using ECG gated acquisition
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/12543 |
Resumo: | We propose a functional parametric analysis method using ECG-gated 99mTc-labeled red blood cell (RBC) imaging for detection and characterization of periodic variations in local blood activity in the lungs during cardiac cycle. We validated in animal experiments that such count variations correlate with cyclical pulmonary blood flow and may be used for evaluation of systemic-to-pulmonary shunts. Clinical studies were performed in 48 patients. After labeling the ABC pool with 99mTc, ECG-gated gamma camera images of both lung fields were acquired and processed to obtain Fourier transforms of time/activity functions in selected regions. The first harmonic parametric images of amplitude and phase were derived. There was an excellent correlation (r = 0.92) between activity variations and pulsatile flow measured by our method with that obtained by the thermodilution method in dog experiments (n = 10) after implantation of a systemic-to-pulmonary shunt. Patient studies showed the technique to be sensitive in detecting and quantifying abnormal systemic-to-pulmonary blood flow. Lung pulsatile flow can thus be noninvasively measured from functional parametric phase and amplitude images; the technique may be useful for detecting and quantifying abnormal systemic-to-pulmonary blood flow in man |
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spelling |
Evaluation of pulmonary systemic blood flow using ECG gated acquisitionWe propose a functional parametric analysis method using ECG-gated 99mTc-labeled red blood cell (RBC) imaging for detection and characterization of periodic variations in local blood activity in the lungs during cardiac cycle. We validated in animal experiments that such count variations correlate with cyclical pulmonary blood flow and may be used for evaluation of systemic-to-pulmonary shunts. Clinical studies were performed in 48 patients. After labeling the ABC pool with 99mTc, ECG-gated gamma camera images of both lung fields were acquired and processed to obtain Fourier transforms of time/activity functions in selected regions. The first harmonic parametric images of amplitude and phase were derived. There was an excellent correlation (r = 0.92) between activity variations and pulsatile flow measured by our method with that obtained by the thermodilution method in dog experiments (n = 10) after implantation of a systemic-to-pulmonary shunt. Patient studies showed the technique to be sensitive in detecting and quantifying abnormal systemic-to-pulmonary blood flow. Lung pulsatile flow can thus be noninvasively measured from functional parametric phase and amplitude images; the technique may be useful for detecting and quantifying abnormal systemic-to-pulmonary blood flow in manSociety of Nuclear Medicine1993info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/12543http://hdl.handle.net/10316/12543engJournal of Nuclear Medicine. 34:9 1441-14460161-5505Lima, João J. Pedroso deBotelho, Maria Filomena R.Rafael, José A. S.Bernardo, JoãoGonçalves, Lino M.Pacheco, Maria de FátimaSantos, Cristina A.Pinto, António J.Cerqueira, Manuel D.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T03:50:05Zoai:estudogeral.uc.pt:10316/12543Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:37.089236Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
title |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
spellingShingle |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition Lima, João J. Pedroso de |
title_short |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
title_full |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
title_fullStr |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
title_full_unstemmed |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
title_sort |
Evaluation of pulmonary systemic blood flow using ECG gated acquisition |
author |
Lima, João J. Pedroso de |
author_facet |
Lima, João J. Pedroso de Botelho, Maria Filomena R. Rafael, José A. S. Bernardo, João Gonçalves, Lino M. Pacheco, Maria de Fátima Santos, Cristina A. Pinto, António J. Cerqueira, Manuel D. |
author_role |
author |
author2 |
Botelho, Maria Filomena R. Rafael, José A. S. Bernardo, João Gonçalves, Lino M. Pacheco, Maria de Fátima Santos, Cristina A. Pinto, António J. Cerqueira, Manuel D. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, João J. Pedroso de Botelho, Maria Filomena R. Rafael, José A. S. Bernardo, João Gonçalves, Lino M. Pacheco, Maria de Fátima Santos, Cristina A. Pinto, António J. Cerqueira, Manuel D. |
description |
We propose a functional parametric analysis method using ECG-gated 99mTc-labeled red blood cell (RBC) imaging for detection and characterization of periodic variations in local blood activity in the lungs during cardiac cycle. We validated in animal experiments that such count variations correlate with cyclical pulmonary blood flow and may be used for evaluation of systemic-to-pulmonary shunts. Clinical studies were performed in 48 patients. After labeling the ABC pool with 99mTc, ECG-gated gamma camera images of both lung fields were acquired and processed to obtain Fourier transforms of time/activity functions in selected regions. The first harmonic parametric images of amplitude and phase were derived. There was an excellent correlation (r = 0.92) between activity variations and pulsatile flow measured by our method with that obtained by the thermodilution method in dog experiments (n = 10) after implantation of a systemic-to-pulmonary shunt. Patient studies showed the technique to be sensitive in detecting and quantifying abnormal systemic-to-pulmonary blood flow. Lung pulsatile flow can thus be noninvasively measured from functional parametric phase and amplitude images; the technique may be useful for detecting and quantifying abnormal systemic-to-pulmonary blood flow in man |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/12543 http://hdl.handle.net/10316/12543 |
url |
http://hdl.handle.net/10316/12543 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Nuclear Medicine. 34:9 1441-1446 0161-5505 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Society of Nuclear Medicine |
publisher.none.fl_str_mv |
Society of Nuclear Medicine |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133707914706944 |