Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico

Detalhes bibliográficos
Autor(a) principal: Taulaigo, A
Data de Publicação: 2020
Outros Autores: Pedro, B, Mariano, M, Paiva Nunes, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4494
Resumo: Introduction: In order to personalize stroke treatment, it is important to know if there are differences between genders in clinical features, acute phase treatment and outcomes. Material and Methods: Longitudinal retrospective study that included patients with ischemic stroke, admitted in a stroke unit during a 30 months period and treated with throm bectomy with or without thrombolysis. The objective was to assess gender differences. Results: Of 594 patients included, 50% were women. At admission, women had higher median age (78 vs 73 years), higher modified Rankin Score (mRS) and higher median Na tional Institutes of Health Stroke Scale (NIHSS). No gender differences were found in treatment type, median time be tween symptoms onset and computed tomography, between computed tomography and thrombolysis and with respect to revascularization success. Disability expressed by mRS and mortality at 3 months were similar between genders. More women had atrial fibrillation (AF) (51% vs 35%), nevertheless, less women with known AF were receiving anticoagulant ther apy before the event, compared to men (38% vs 52%). Discussion: Even if women were older and had worse pre morbid functional status, no gender differences were evident with regard to acute phase treatment efficacy and medium term outcomes. Conclusion: In women, age should not limit acute phase treatment of stroke and decisions should be individualized
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spelling Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral IsquémicoGender Differences in Acute Ischemic Stroke TreatmentHCC MEDHSJ NEUAcidente Vascular CerebralFatores SexuaisIsquemiaIntroduction: In order to personalize stroke treatment, it is important to know if there are differences between genders in clinical features, acute phase treatment and outcomes. Material and Methods: Longitudinal retrospective study that included patients with ischemic stroke, admitted in a stroke unit during a 30 months period and treated with throm bectomy with or without thrombolysis. The objective was to assess gender differences. Results: Of 594 patients included, 50% were women. At admission, women had higher median age (78 vs 73 years), higher modified Rankin Score (mRS) and higher median Na tional Institutes of Health Stroke Scale (NIHSS). No gender differences were found in treatment type, median time be tween symptoms onset and computed tomography, between computed tomography and thrombolysis and with respect to revascularization success. Disability expressed by mRS and mortality at 3 months were similar between genders. More women had atrial fibrillation (AF) (51% vs 35%), nevertheless, less women with known AF were receiving anticoagulant ther apy before the event, compared to men (38% vs 52%). Discussion: Even if women were older and had worse pre morbid functional status, no gender differences were evident with regard to acute phase treatment efficacy and medium term outcomes. Conclusion: In women, age should not limit acute phase treatment of stroke and decisions should be individualizedIntrodução: Na abordagem personalizada do acidente vascular cerebral (AVC) é importante definir se existem diferenças de género relativamente às caraterísticas clínicas, tratamento de fase aguda e resultados. Material e Métodos: Estudo longitudinal retrospetivo que incluiu doentes com AVC isquémico admitidos na Unidade Cerebro Vascular, durante 30 meses, tratados com trombectomia com ou sem trombólise prévia, com o objetivo de avaliar diferenças de género. Resultados: De 594 doentes, 50% eram mulheres apresentando, à admissão, idade mediana maior (78 vs 73 anos), maior pontuação na escala modificada de Rankin (mRS) e na National Institutes of Health Stroke Scale (NIHSS). Não houve diferenças no tipo de tratamento, no tempo mediano entre o início dos sintomas e tomografia computadorizada (TC), entre o tempo TC-trombólise ou na eficácia da revascularização. A disabilidade expressa pelo valor de mRS e a mortalidade aos 3 meses foram sobreponíveis entre géneros. Mais mulheres sofriam de fibrilhação auricular (FA) (51% vs 35%), no entanto menos mulheres com FA conhecida recebiam terapêutica anticoagulante antes do evento, comparativamente aos homens (38% vs 52%). Discussão: Apesar das mulheres apresentarem idade mais elevada e maior grau de dependência, não existiram diferenças de género na eficácia do tratamento de fase aguda nem nos resultados a médio prazo. Conclusão: No género feminino, a idade não deve constituir uma limitação à realização de terapêutica de fase aguda do AVC.Sociedade Portuguesa de Medicina InternaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPETaulaigo, APedro, BMariano, MPaiva Nunes, A2023-04-13T14:48:55Z2020-072020-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4494engMed Interna 2020;27(3):219-22810.24950/O/34/20/3/2020info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-16T05:45:35Zoai:repositorio.chlc.min-saude.pt:10400.17/4494Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:49:37.069421Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
Gender Differences in Acute Ischemic Stroke Treatment
title Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
spellingShingle Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
Taulaigo, A
HCC MED
HSJ NEU
Acidente Vascular Cerebral
Fatores Sexuais
Isquemia
title_short Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
title_full Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
title_fullStr Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
title_full_unstemmed Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
title_sort Diferenças de Género no Tratamento de Fase Aguda do Acidente Vascular Cerebral Isquémico
author Taulaigo, A
author_facet Taulaigo, A
Pedro, B
Mariano, M
Paiva Nunes, A
author_role author
author2 Pedro, B
Mariano, M
Paiva Nunes, A
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Taulaigo, A
Pedro, B
Mariano, M
Paiva Nunes, A
dc.subject.por.fl_str_mv HCC MED
HSJ NEU
Acidente Vascular Cerebral
Fatores Sexuais
Isquemia
topic HCC MED
HSJ NEU
Acidente Vascular Cerebral
Fatores Sexuais
Isquemia
description Introduction: In order to personalize stroke treatment, it is important to know if there are differences between genders in clinical features, acute phase treatment and outcomes. Material and Methods: Longitudinal retrospective study that included patients with ischemic stroke, admitted in a stroke unit during a 30 months period and treated with throm bectomy with or without thrombolysis. The objective was to assess gender differences. Results: Of 594 patients included, 50% were women. At admission, women had higher median age (78 vs 73 years), higher modified Rankin Score (mRS) and higher median Na tional Institutes of Health Stroke Scale (NIHSS). No gender differences were found in treatment type, median time be tween symptoms onset and computed tomography, between computed tomography and thrombolysis and with respect to revascularization success. Disability expressed by mRS and mortality at 3 months were similar between genders. More women had atrial fibrillation (AF) (51% vs 35%), nevertheless, less women with known AF were receiving anticoagulant ther apy before the event, compared to men (38% vs 52%). Discussion: Even if women were older and had worse pre morbid functional status, no gender differences were evident with regard to acute phase treatment efficacy and medium term outcomes. Conclusion: In women, age should not limit acute phase treatment of stroke and decisions should be individualized
publishDate 2020
dc.date.none.fl_str_mv 2020-07
2020-07-01T00:00:00Z
2023-04-13T14:48:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4494
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Med Interna 2020;27(3):219-228
10.24950/O/34/20/3/2020
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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