Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae

Detalhes bibliográficos
Autor(a) principal: Grosso, Filipa
Data de Publicação: 2015
Outros Autores: Silva, Liliana, Sousa, C., Ramos, Helena, Quinteira, Sandra, Peixe, Luísa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/38723
Resumo: Acinetobacter bereziniae clinical relevance is starting to be recognized; however, very few descriptions of its carbapenem resistance currently exist. Here we characterize two carbapenem-resistant A. bereziniae isolates. Materials & methods: Isolates were obtained from environmental and clinical samples. Carbapenemases were searched by phenotypic, biochemical and PCR assays. Clonality was studied by ApaI-PFGE and genetic location for carbapenemase genes were assessed by I-CeuI and S1 hybridizations. Results: Isolates were not clonally related but both produced the exclusively Portuguese IMP-5, with the clinical isolate also producing an OXA-58. The carbapenemase genes were plasmid located. Conclusion: Our results emphasize the role of non-baumannii Acinetobacter species as important reservoirs of clinically relevant resistance genes that could also contribute to their emergence as nosocomial pathogens
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spelling Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniaeAcinetobacter bereziniaecarbapenem resistanceIMP-5integronmetallo--lactamaseoxacillinasemetallo-ß-lactamaseScience & TechnologyAcinetobacter bereziniae clinical relevance is starting to be recognized; however, very few descriptions of its carbapenem resistance currently exist. Here we characterize two carbapenem-resistant A. bereziniae isolates. Materials & methods: Isolates were obtained from environmental and clinical samples. Carbapenemases were searched by phenotypic, biochemical and PCR assays. Clonality was studied by ApaI-PFGE and genetic location for carbapenemase genes were assessed by I-CeuI and S1 hybridizations. Results: Isolates were not clonally related but both produced the exclusively Portuguese IMP-5, with the clinical isolate also producing an OXA-58. The carbapenemase genes were plasmid located. Conclusion: Our results emphasize the role of non-baumannii Acinetobacter species as important reservoirs of clinically relevant resistance genes that could also contribute to their emergence as nosocomial pathogensThis work was funded by FEDER funds through the Operational Programme for Competitiveness Factors – COMPETE and by National Funds through FCT – Foundation for Science and Technology under the project Pest-C/EQB/LA0006/2013. L Silva and F Grosso were supported by grants from FCT (SFRH/BD/88028/2012 and SFRH/BPD/95556/2013, respectively). C Sousa was funded by an FCT contract CIENCIA2008. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.Future MedicineUniversidade do MinhoGrosso, FilipaSilva, LilianaSousa, C.Ramos, HelenaQuinteira, SandraPeixe, Luísa20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38723engGrosso, Filipa; Silva, Liliana; Sousa, C.; Ramos, Helena; Quinteira, Sandra; Peixe, Luísa, Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae. Future Microbiology, 10(10), 1609-1613, 20151746-09131746-092110.2217/fmb.15.8826439605http://www.futuremedicine.com/loi/fmbinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:15:41Zoai:repositorium.sdum.uminho.pt:1822/38723Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:08:09.558253Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
title Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
spellingShingle Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
Grosso, Filipa
Acinetobacter bereziniae
carbapenem resistance
IMP-5
integron
metallo--lactamase
oxacillinase
metallo-ß-lactamase
Science & Technology
title_short Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
title_full Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
title_fullStr Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
title_full_unstemmed Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
title_sort Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae
author Grosso, Filipa
author_facet Grosso, Filipa
Silva, Liliana
Sousa, C.
Ramos, Helena
Quinteira, Sandra
Peixe, Luísa
author_role author
author2 Silva, Liliana
Sousa, C.
Ramos, Helena
Quinteira, Sandra
Peixe, Luísa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Grosso, Filipa
Silva, Liliana
Sousa, C.
Ramos, Helena
Quinteira, Sandra
Peixe, Luísa
dc.subject.por.fl_str_mv Acinetobacter bereziniae
carbapenem resistance
IMP-5
integron
metallo--lactamase
oxacillinase
metallo-ß-lactamase
Science & Technology
topic Acinetobacter bereziniae
carbapenem resistance
IMP-5
integron
metallo--lactamase
oxacillinase
metallo-ß-lactamase
Science & Technology
description Acinetobacter bereziniae clinical relevance is starting to be recognized; however, very few descriptions of its carbapenem resistance currently exist. Here we characterize two carbapenem-resistant A. bereziniae isolates. Materials & methods: Isolates were obtained from environmental and clinical samples. Carbapenemases were searched by phenotypic, biochemical and PCR assays. Clonality was studied by ApaI-PFGE and genetic location for carbapenemase genes were assessed by I-CeuI and S1 hybridizations. Results: Isolates were not clonally related but both produced the exclusively Portuguese IMP-5, with the clinical isolate also producing an OXA-58. The carbapenemase genes were plasmid located. Conclusion: Our results emphasize the role of non-baumannii Acinetobacter species as important reservoirs of clinically relevant resistance genes that could also contribute to their emergence as nosocomial pathogens
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38723
url http://hdl.handle.net/1822/38723
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Grosso, Filipa; Silva, Liliana; Sousa, C.; Ramos, Helena; Quinteira, Sandra; Peixe, Luísa, Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae. Future Microbiology, 10(10), 1609-1613, 2015
1746-0913
1746-0921
10.2217/fmb.15.88
26439605
http://www.futuremedicine.com/loi/fmb
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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