Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates

Detalhes bibliográficos
Autor(a) principal: Martins, Celso
Data de Publicação: 2015
Outros Autores: Correia, Vanessa G., Aguiar-Ricardo, Ana, Cunha, Ângela, Moutinho, Maria Guilhermina M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/13372
Resumo: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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spelling Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolatesAntimicrobial oxazolinesOpportunistic pathogensMICViability assayClinical isolatesThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made."Background: The search for new antimicrobial compounds able to overcome the global issue of microbial resistance to antibiotics is a priority worldwide. Moreover, several commensal microorganisms have been increasingly associated to opportunistic microbial infections. Having previously disclosed the green synthesis and preliminary characterization of the oligomers [linear oligo(ethylenimine) hydrochloride and oligo(2-methyl-2-oxazoline) quaternized with N,Ndimethyldodecylamine] we herein report on the screening of these oligomers against a battery of 69 clinical isolates of Aerococcus spp., Candida spp., Staphylococcus spp. and Streptococcus spp. Findings: The isolates’ susceptibility to both oligomers was evaluated by determining their minimal inhibitory concentration (MIC) and the biocidal effectiveness of each compound was further confirmed through spectrophotometric measurements and fluorescence microscopy. The MIC values of the 69 isolates were highly variable, yet favourably comparable with those of other antimicrobial polymers. The viability assays resulted in 100% of microbial killing rate after only 5 min, highlighting the promising antimicrobial action of these oligomers. Conclusions: Though further studies are required, evidence suggests that a strong effort should be done in order to confirm these compounds as valid alternatives for several clinical applications. This is reinforced by their well described biocompatibility with human tissues and by their proposed mechanism of action which difficult the development of microbial resistance to these compounds."This work was partially supported by Fundação para a Ciência e Tecnologia (FCT), Project PTDC/QUI/73939/2006, and by Instituto Superior de Ciências da Saúde Egas Moniz (ISCSEM).SpringerRepositório ComumMartins, CelsoCorreia, Vanessa G.Aguiar-Ricardo, AnaCunha, ÂngelaMoutinho, Maria Guilhermina M.2016-04-29T08:42:41Z2015-07-28T00:00:00Z2015-07-28T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/13372engMartins et al. SpringerPlus (2015) 4:3822193-180110.1186/s40064-015-1166-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:05Zoai:comum.rcaap.pt:10400.26/13372Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:07:18.924611Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
title Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
spellingShingle Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
Martins, Celso
Antimicrobial oxazolines
Opportunistic pathogens
MIC
Viability assay
Clinical isolates
title_short Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
title_full Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
title_fullStr Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
title_full_unstemmed Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
title_sort Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
author Martins, Celso
author_facet Martins, Celso
Correia, Vanessa G.
Aguiar-Ricardo, Ana
Cunha, Ângela
Moutinho, Maria Guilhermina M.
author_role author
author2 Correia, Vanessa G.
Aguiar-Ricardo, Ana
Cunha, Ângela
Moutinho, Maria Guilhermina M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Martins, Celso
Correia, Vanessa G.
Aguiar-Ricardo, Ana
Cunha, Ângela
Moutinho, Maria Guilhermina M.
dc.subject.por.fl_str_mv Antimicrobial oxazolines
Opportunistic pathogens
MIC
Viability assay
Clinical isolates
topic Antimicrobial oxazolines
Opportunistic pathogens
MIC
Viability assay
Clinical isolates
description This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-28T00:00:00Z
2015-07-28T00:00:00Z
2016-04-29T08:42:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/13372
url http://hdl.handle.net/10400.26/13372
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins et al. SpringerPlus (2015) 4:382
2193-1801
10.1186/s40064-015-1166-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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