Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/113593 |
Resumo: | This study is part of the PhD thesis program of one of the authors (TPdS), supervised (MMC) and co-supervised (PN) by other two, conducted in NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. TP acknowledges the support of Fundação para a Ciência e Tecnologia, Portugal (Project UID/BIO/04565/ 2020), and Programa Operacional Regional de Lisboa 2020 (Project N. 007317). The authors are grateful to Joana Castro, PhD, from Medinres - Medical Information and Research, for her advice in the statistical analysis. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligandChronic coronary syndromecoronary artery diseaseinflammationsoluble CD40 ligandThis study is part of the PhD thesis program of one of the authors (TPdS), supervised (MMC) and co-supervised (PN) by other two, conducted in NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. TP acknowledges the support of Fundação para a Ciência e Tecnologia, Portugal (Project UID/BIO/04565/ 2020), and Programa Operacional Regional de Lisboa 2020 (Project N. 007317). The authors are grateful to Joana Castro, PhD, from Medinres - Medical Information and Research, for her advice in the statistical analysis.Introduction: Inflammation contributes to the initiation and progression of atherosclerosis, although the underlying inflammatory pathways are not entirely known. Specifically, the role of the proinflammatory soluble CD40 ligand (sCD40L) on the expression of chronic coronary syndrome (CCS) is not completely understood. We evaluated whether sCD40L expression is associated with the presence of CCS and with the clinical and anatomical severity of CCS. Methods: We prospectively recruited 94 participants, assigned to two groups matched by age and sex, without coronary artery disease (n=26) and with CCS (n=68). Clinical, laboratory and anatomical data were prospectively collected, and serum levels of sCD40L were measured. Results: In patients with CCS, classic cardiovascular risk factors were more prevalent, and the sCD40L levels, leukocyte and neutrophil counts, and neutrophil/lymphocyte ratio, but not the C-reactive protein levels, were significantly higher than those in controls. sCD40L was independently associated with the presence of obstructive coronary artery disease in multivariate analysis. Regarding CCS severity, sCD40L levels showed a significant stepwise increase with increasing angina severity (ANOVA P=0.001). In addition, sCD40L was independently associated with the anatomical severity of coronary artery disease, as assessed by the Gensini score. Among patients with CCS, those with previous coronary artery bypass grafting (n=23) had lower sCD40L levels than patients waiting for revascularization (n=45) [4.3 (2.1) ng/mL vs. 6.8 (3.5) ng/mL, P=0.001]. Conclusions: The expression of the proinflammatory sCD40L was associated with the presence of CCS and reflected the clinical and anatomical severity of CCS. In addition, we describe for the first time the association between prior CABG and reduced sCD40L levels in patients with CCS.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNPereira-da-Silva, TiagoNapoleao, PatriciaPinheiro, TeresaSelas, MafaldaSilva, FilipaFerreira, Rui CruzCarmo, Miguel Mota2021-03-09T23:57:20Z2020-10-152020-10-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/113593eng2160-200XPURE: 26667932info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:56:31Zoai:run.unl.pt:10362/113593Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:20.209791Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
title |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
spellingShingle |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand Pereira-da-Silva, Tiago Chronic coronary syndrome coronary artery disease inflammation soluble CD40 ligand |
title_short |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
title_full |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
title_fullStr |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
title_full_unstemmed |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
title_sort |
Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand |
author |
Pereira-da-Silva, Tiago |
author_facet |
Pereira-da-Silva, Tiago Napoleao, Patricia Pinheiro, Teresa Selas, Mafalda Silva, Filipa Ferreira, Rui Cruz Carmo, Miguel Mota |
author_role |
author |
author2 |
Napoleao, Patricia Pinheiro, Teresa Selas, Mafalda Silva, Filipa Ferreira, Rui Cruz Carmo, Miguel Mota |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Pereira-da-Silva, Tiago Napoleao, Patricia Pinheiro, Teresa Selas, Mafalda Silva, Filipa Ferreira, Rui Cruz Carmo, Miguel Mota |
dc.subject.por.fl_str_mv |
Chronic coronary syndrome coronary artery disease inflammation soluble CD40 ligand |
topic |
Chronic coronary syndrome coronary artery disease inflammation soluble CD40 ligand |
description |
This study is part of the PhD thesis program of one of the authors (TPdS), supervised (MMC) and co-supervised (PN) by other two, conducted in NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. TP acknowledges the support of Fundação para a Ciência e Tecnologia, Portugal (Project UID/BIO/04565/ 2020), and Programa Operacional Regional de Lisboa 2020 (Project N. 007317). The authors are grateful to Joana Castro, PhD, from Medinres - Medical Information and Research, for her advice in the statistical analysis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-15 2020-10-15T00:00:00Z 2021-03-09T23:57:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/113593 |
url |
http://hdl.handle.net/10362/113593 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2160-200X PURE: 26667932 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138035055460352 |