The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis

Detalhes bibliográficos
Autor(a) principal: Pereira-Da-silva, Tiago
Data de Publicação: 2021
Outros Autores: Napoleão, Patrícia, Pinheiro, Teresa, Selas, Mafalda, Silva, Filipa, Ferreira, Rui Cruz, Carmo, Miguel Mota
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/110600
Resumo: Funding: T.P. has received research support from Fundação para a Ciência e Tecnologia, Portugal [Project UID/BIO/04565/2020], and Programa Operacional Regional de Lisboa 2020 [Project N. 007317].
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spelling The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosisAtherosclerosisCarotid artery diseaseCoronary artery diseaseInflammationLower extremity arterial diseaseSoluble CD40 ligandMedicine(all)Funding: T.P. has received research support from Fundação para a Ciência e Tecnologia, Portugal [Project UID/BIO/04565/2020], and Programa Operacional Regional de Lisboa 2020 [Project N. 007317].Background and objectives: Polyvascular atherosclerosis is frequent and associated with a high cardiovascular risk, although the mechanisms regulating the atherosclerosis extent to single or multiple arterial territories are still poorly understood. Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory mediator associated with the presence of single-territorial atherosclerosis. We assessed whether the sCD40L expression is associated with the atherosclerosis extent to single or multiple arterial territories and with the atherosclerosis severity in different territories. Materials and Methods: We prospectively enrolled 94 participants with no atherosclerosis (controls, n = 26); isolated coronary atherosclerosis (group 1, n = 20); coronary and lower extremity (LE) atherosclerosis (group 2, n = 18); coronary and carotid atherosclerosis (group 3, n = 12); and coronary, LE, and carotid atherosclerosis (group 4, n = 18). Serum sCD40L levels were quantified. Results: The sCD40L levels (ng/mL, mean (standard deviation)) were 4.0 (1.5), 5.6 (2.6), 7.2 (4.2), 5.9 (3.7), and 5.1 (2.4) in controls and groups 1 to 4, respectively (ANOVA p = 0.012). In nonrevascularized patients, the sCD40L levels were significantly higher in group 2 than in group 1 and were correlated with the number of LE diseased segments. Prior LE bypass surgery was associated with lower sCD40L levels. Coexistence of coronary and LE atherosclerosis was independently associated with the sCD40L levels. Conclusions: The sCD40L levels were increased in stable atherosclerosis, particularly in polyvascular coronary and LE atherosclerosis. The number of LE diseased segments and prior LE revascularization were associated with sCD40L expression. To our knowledge, these are novel data, which provide insights into the mechanisms underlying multi-territorial atherosclerosis expression. sCD40L may be a promising noninvasive tool for refining the stratification of the systemic atherosclerotic burden.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNPereira-Da-silva, TiagoNapoleão, PatríciaPinheiro, TeresaSelas, MafaldaSilva, FilipaFerreira, Rui CruzCarmo, Miguel Mota2021-01-22T23:40:45Z2021-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttp://hdl.handle.net/10362/110600eng1010-660XPURE: 27651931https://doi.org/10.3390/medicina57010039info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:54:29Zoai:run.unl.pt:10362/110600Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:41:41.030529Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
title The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
spellingShingle The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
Pereira-Da-silva, Tiago
Atherosclerosis
Carotid artery disease
Coronary artery disease
Inflammation
Lower extremity arterial disease
Soluble CD40 ligand
Medicine(all)
title_short The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
title_full The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
title_fullStr The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
title_full_unstemmed The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
title_sort The proinflammatory soluble CD40 ligand is associated with the systemic extent of stable atherosclerosis
author Pereira-Da-silva, Tiago
author_facet Pereira-Da-silva, Tiago
Napoleão, Patrícia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
author_role author
author2 Napoleão, Patrícia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Pereira-Da-silva, Tiago
Napoleão, Patrícia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
dc.subject.por.fl_str_mv Atherosclerosis
Carotid artery disease
Coronary artery disease
Inflammation
Lower extremity arterial disease
Soluble CD40 ligand
Medicine(all)
topic Atherosclerosis
Carotid artery disease
Coronary artery disease
Inflammation
Lower extremity arterial disease
Soluble CD40 ligand
Medicine(all)
description Funding: T.P. has received research support from Fundação para a Ciência e Tecnologia, Portugal [Project UID/BIO/04565/2020], and Programa Operacional Regional de Lisboa 2020 [Project N. 007317].
publishDate 2021
dc.date.none.fl_str_mv 2021-01-22T23:40:45Z
2021-01
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/110600
url http://hdl.handle.net/10362/110600
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1010-660X
PURE: 27651931
https://doi.org/10.3390/medicina57010039
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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