Neurofilament proteins in neurodegenerative diseases
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/7895 https://doi.org/10.1007/s00018-004-4268-8 |
Resumo: | The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic mice, these studies provided new insights into neurofilament function. The function of each subunit, the relationship of neurofilaments with other cytoskeletal elements and their clinical significance are topics of increasing attention. |
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Neurofilament proteins in neurodegenerative diseasesThe function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic mice, these studies provided new insights into neurofilament function. The function of each subunit, the relationship of neurofilaments with other cytoskeletal elements and their clinical significance are topics of increasing attention.2004info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/7895http://hdl.handle.net/10316/7895https://doi.org/10.1007/s00018-004-4268-8engCellular and Molecular Life Sciences (CMLS). 61:24 (2004) 3057-3075Liu, Q.Xie, F.Siedlak, S. L.Nunomura, A.Honda, K.Moreira, P. I.Zhua, X.Smith, M. A.Perry, G.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-29T10:10:32Zoai:estudogeral.uc.pt:10316/7895Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:35.832721Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neurofilament proteins in neurodegenerative diseases |
title |
Neurofilament proteins in neurodegenerative diseases |
spellingShingle |
Neurofilament proteins in neurodegenerative diseases Liu, Q. |
title_short |
Neurofilament proteins in neurodegenerative diseases |
title_full |
Neurofilament proteins in neurodegenerative diseases |
title_fullStr |
Neurofilament proteins in neurodegenerative diseases |
title_full_unstemmed |
Neurofilament proteins in neurodegenerative diseases |
title_sort |
Neurofilament proteins in neurodegenerative diseases |
author |
Liu, Q. |
author_facet |
Liu, Q. Xie, F. Siedlak, S. L. Nunomura, A. Honda, K. Moreira, P. I. Zhua, X. Smith, M. A. Perry, G. |
author_role |
author |
author2 |
Xie, F. Siedlak, S. L. Nunomura, A. Honda, K. Moreira, P. I. Zhua, X. Smith, M. A. Perry, G. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Liu, Q. Xie, F. Siedlak, S. L. Nunomura, A. Honda, K. Moreira, P. I. Zhua, X. Smith, M. A. Perry, G. |
description |
The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic mice, these studies provided new insights into neurofilament function. The function of each subunit, the relationship of neurofilaments with other cytoskeletal elements and their clinical significance are topics of increasing attention. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/7895 http://hdl.handle.net/10316/7895 https://doi.org/10.1007/s00018-004-4268-8 |
url |
http://hdl.handle.net/10316/7895 https://doi.org/10.1007/s00018-004-4268-8 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cellular and Molecular Life Sciences (CMLS). 61:24 (2004) 3057-3075 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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