The role of PC-MRI in neurodegenerative diseases

• Autor(a) principal: Attier-Zmudka,Jadwiga
• Data de Publicação: 2017
• Outros Autores: Chaarani,Bader, Couvillers,Frederique, Gondry-Jouet,Catherine, Sérot,Jean-Marie, Balédent,Olivier
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Geriatrics, Gerontology and Aging (Online)
• Texto Completo: https://ggaging.com/details/424
• topic: Magnetic Resonance Imaging/methods; neurodegenerative diseases; Elderly.

<p><b>INTRODUCTION:</b> Neurodegenerative diseases, a major public health problem, could have a vascular origin. Phase-contrast magnetic resonance imaging (PC-MRI) enables reliable, non-invasive, and rapid measurements of cerebrospinal fluid (CSF) and blood flows, and evaluation of the mechanical coupling between cerebral blood and CSF flows throughout the cardiac cycle (CC).<br> <b>OBJECTIVES:</b> Our purpose was to evaluate the potential of PC-MRI to the study of cerebral blood and CSF flows in patients with neurodegenerative diseases such as Alzheimer’s disease (AD), Mild cognitive impairment with amnesic disorders (MCIa) and Vascular Dementia (VD).<br> <b>METHODS:</b> The elderly population consisted of 20 AD (age: 80 ± 5 years); 12 AD patients with vascular cerebral lesions (ADvasc) (age: 81 ± 5 years), 10 MCIa patients (age: 80 ± 7 years), and 8 VD patients (age: 78 ± 7 years) were identified. They underwent the same PC-MRI protocol and were compared to 13 age-matched Healthy Elderly (HE) (age: 71± 9 years). Arterial blood pressure was analyzed to detect patients with hypertension.<br> <b>RESULTS:</b> Significantly higher cerebral blood and CSF flows were observed in HE when compared to VD, AD and ADvasc, (p&lt;0.05), but not MCIa patients who yielded the highest cerebral arterial and venous blood flows and stroke volumes compared to the other patients, (p&lt;0.05). The highest oscillations of CSF were also detected in MCIa patients (p&lt;0.05).<br> <b>CONCLUSION:</b> Our preliminary data suggests an increase in cerebral arterial blood and CSF flows in MCIa. PC-MRI provides a new hydrodynamic view, which may help evaluate a potential role of cardiovascular alterations in neurodegenerative diseases.</p>