Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Detalhes bibliográficos
Autor(a) principal: Alves, C..H.
Data de Publicação: 2020
Outros Autores: Fernandes, R., Santiago, A. R., Ambrósio, A. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/90487
https://doi.org/10.3390/cells9051217
Resumo: The retina is a highly metabolically active tissue with high-level consumption of nutrientsand oxygen. This high metabolic demand requires a properly developed and maintained vascularsystem. The retina is nourished by two systems: the central retinal artery that supplies the innerretina and the choriocapillaris that supplies the outer retina and retinal pigment epithelium (RPE).Pathological neovascularization, characterized by endothelial cell proliferation and new vesselformation, is a common hallmark in several retinal degenerative diseases, including age-relatedmacular degeneration (AMD). A limited number of studies have suggested that microglia, the residentimmune cells of the retina, have an important role not only in the pathology but also in the formationand physiology of the retinal vascular system. Here, we review the current knowledge on microglialinteraction with the retinal vascular system under physiological and pathological conditions. To do so,we first highlight the role of microglial cells in the formation and maintenance of the retinal vasculaturesystem. Thereafter, we discuss the molecular signaling mechanisms through which microglial cellscontribute to the alterations in retinal and choroidal vasculatures and to the neovascularizationin AMD.
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spelling Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degenerationage-related macular degeneration (AMD)retinachoroidmicrogliaretinal vasculatureinflammationneogenesisangiogenesisThe retina is a highly metabolically active tissue with high-level consumption of nutrientsand oxygen. This high metabolic demand requires a properly developed and maintained vascularsystem. The retina is nourished by two systems: the central retinal artery that supplies the innerretina and the choriocapillaris that supplies the outer retina and retinal pigment epithelium (RPE).Pathological neovascularization, characterized by endothelial cell proliferation and new vesselformation, is a common hallmark in several retinal degenerative diseases, including age-relatedmacular degeneration (AMD). A limited number of studies have suggested that microglia, the residentimmune cells of the retina, have an important role not only in the pathology but also in the formationand physiology of the retinal vascular system. Here, we review the current knowledge on microglialinteraction with the retinal vascular system under physiological and pathological conditions. To do so,we first highlight the role of microglial cells in the formation and maintenance of the retinal vasculaturesystem. Thereafter, we discuss the molecular signaling mechanisms through which microglial cellscontribute to the alterations in retinal and choroidal vasculatures and to the neovascularizationin AMD.This research was funded by National Funds via FCT (Foundation for Science and Technology) throughthe Strategic Project UIDB/04539/2020 and UIDP/04539/2020 (CIBB); and CEECIND/00886/2017 to C.H.AMDPI2020-05-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/90487http://hdl.handle.net/10316/90487https://doi.org/10.3390/cells9051217eng2073-4409https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290930/pdf/cells-09-01217.pdfAlves, C..H.Fernandes, R.Santiago, A. R.Ambrósio, A. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T04:21:25Zoai:estudogeral.uc.pt:10316/90487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:10:36.787450Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
title Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
spellingShingle Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
Alves, C..H.
age-related macular degeneration (AMD)
retina
choroid
microglia
retinal vasculature
inflammation
neogenesis
angiogenesis
title_short Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
title_full Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
title_fullStr Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
title_full_unstemmed Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
title_sort Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
author Alves, C..H.
author_facet Alves, C..H.
Fernandes, R.
Santiago, A. R.
Ambrósio, A. F.
author_role author
author2 Fernandes, R.
Santiago, A. R.
Ambrósio, A. F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Alves, C..H.
Fernandes, R.
Santiago, A. R.
Ambrósio, A. F.
dc.subject.por.fl_str_mv age-related macular degeneration (AMD)
retina
choroid
microglia
retinal vasculature
inflammation
neogenesis
angiogenesis
topic age-related macular degeneration (AMD)
retina
choroid
microglia
retinal vasculature
inflammation
neogenesis
angiogenesis
description The retina is a highly metabolically active tissue with high-level consumption of nutrientsand oxygen. This high metabolic demand requires a properly developed and maintained vascularsystem. The retina is nourished by two systems: the central retinal artery that supplies the innerretina and the choriocapillaris that supplies the outer retina and retinal pigment epithelium (RPE).Pathological neovascularization, characterized by endothelial cell proliferation and new vesselformation, is a common hallmark in several retinal degenerative diseases, including age-relatedmacular degeneration (AMD). A limited number of studies have suggested that microglia, the residentimmune cells of the retina, have an important role not only in the pathology but also in the formationand physiology of the retinal vascular system. Here, we review the current knowledge on microglialinteraction with the retinal vascular system under physiological and pathological conditions. To do so,we first highlight the role of microglial cells in the formation and maintenance of the retinal vasculaturesystem. Thereafter, we discuss the molecular signaling mechanisms through which microglial cellscontribute to the alterations in retinal and choroidal vasculatures and to the neovascularizationin AMD.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-14
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/90487
http://hdl.handle.net/10316/90487
https://doi.org/10.3390/cells9051217
url http://hdl.handle.net/10316/90487
https://doi.org/10.3390/cells9051217
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4409
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290930/pdf/cells-09-01217.pdf
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