Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/90487 https://doi.org/10.3390/cells9051217 |
Resumo: | The retina is a highly metabolically active tissue with high-level consumption of nutrientsand oxygen. This high metabolic demand requires a properly developed and maintained vascularsystem. The retina is nourished by two systems: the central retinal artery that supplies the innerretina and the choriocapillaris that supplies the outer retina and retinal pigment epithelium (RPE).Pathological neovascularization, characterized by endothelial cell proliferation and new vesselformation, is a common hallmark in several retinal degenerative diseases, including age-relatedmacular degeneration (AMD). A limited number of studies have suggested that microglia, the residentimmune cells of the retina, have an important role not only in the pathology but also in the formationand physiology of the retinal vascular system. Here, we review the current knowledge on microglialinteraction with the retinal vascular system under physiological and pathological conditions. To do so,we first highlight the role of microglial cells in the formation and maintenance of the retinal vasculaturesystem. Thereafter, we discuss the molecular signaling mechanisms through which microglial cellscontribute to the alterations in retinal and choroidal vasculatures and to the neovascularizationin AMD. |
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Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degenerationage-related macular degeneration (AMD)retinachoroidmicrogliaretinal vasculatureinflammationneogenesisangiogenesisThe retina is a highly metabolically active tissue with high-level consumption of nutrientsand oxygen. This high metabolic demand requires a properly developed and maintained vascularsystem. The retina is nourished by two systems: the central retinal artery that supplies the innerretina and the choriocapillaris that supplies the outer retina and retinal pigment epithelium (RPE).Pathological neovascularization, characterized by endothelial cell proliferation and new vesselformation, is a common hallmark in several retinal degenerative diseases, including age-relatedmacular degeneration (AMD). A limited number of studies have suggested that microglia, the residentimmune cells of the retina, have an important role not only in the pathology but also in the formationand physiology of the retinal vascular system. Here, we review the current knowledge on microglialinteraction with the retinal vascular system under physiological and pathological conditions. To do so,we first highlight the role of microglial cells in the formation and maintenance of the retinal vasculaturesystem. Thereafter, we discuss the molecular signaling mechanisms through which microglial cellscontribute to the alterations in retinal and choroidal vasculatures and to the neovascularizationin AMD.This research was funded by National Funds via FCT (Foundation for Science and Technology) throughthe Strategic Project UIDB/04539/2020 and UIDP/04539/2020 (CIBB); and CEECIND/00886/2017 to C.H.AMDPI2020-05-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/90487http://hdl.handle.net/10316/90487https://doi.org/10.3390/cells9051217eng2073-4409https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290930/pdf/cells-09-01217.pdfAlves, C..H.Fernandes, R.Santiago, A. R.Ambrósio, A. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T04:21:25Zoai:estudogeral.uc.pt:10316/90487Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:10:36.787450Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
title |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
spellingShingle |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration Alves, C..H. age-related macular degeneration (AMD) retina choroid microglia retinal vasculature inflammation neogenesis angiogenesis |
title_short |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
title_full |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
title_fullStr |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
title_full_unstemmed |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
title_sort |
Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration |
author |
Alves, C..H. |
author_facet |
Alves, C..H. Fernandes, R. Santiago, A. R. Ambrósio, A. F. |
author_role |
author |
author2 |
Fernandes, R. Santiago, A. R. Ambrósio, A. F. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alves, C..H. Fernandes, R. Santiago, A. R. Ambrósio, A. F. |
dc.subject.por.fl_str_mv |
age-related macular degeneration (AMD) retina choroid microglia retinal vasculature inflammation neogenesis angiogenesis |
topic |
age-related macular degeneration (AMD) retina choroid microglia retinal vasculature inflammation neogenesis angiogenesis |
description |
The retina is a highly metabolically active tissue with high-level consumption of nutrientsand oxygen. This high metabolic demand requires a properly developed and maintained vascularsystem. The retina is nourished by two systems: the central retinal artery that supplies the innerretina and the choriocapillaris that supplies the outer retina and retinal pigment epithelium (RPE).Pathological neovascularization, characterized by endothelial cell proliferation and new vesselformation, is a common hallmark in several retinal degenerative diseases, including age-relatedmacular degeneration (AMD). A limited number of studies have suggested that microglia, the residentimmune cells of the retina, have an important role not only in the pathology but also in the formationand physiology of the retinal vascular system. Here, we review the current knowledge on microglialinteraction with the retinal vascular system under physiological and pathological conditions. To do so,we first highlight the role of microglial cells in the formation and maintenance of the retinal vasculaturesystem. Thereafter, we discuss the molecular signaling mechanisms through which microglial cellscontribute to the alterations in retinal and choroidal vasculatures and to the neovascularizationin AMD. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/90487 http://hdl.handle.net/10316/90487 https://doi.org/10.3390/cells9051217 |
url |
http://hdl.handle.net/10316/90487 https://doi.org/10.3390/cells9051217 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2073-4409 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290930/pdf/cells-09-01217.pdf |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134000405544960 |