Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/140995 |
Resumo: | Funding: This work was supported by Fundação para a Ciência e Tecnologia project PTDC/MEDPAT/30385/2017 and iNOVA4Health-UIDB/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Educação e Ciência, Portugal, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement. A.C.F. was funded by FCT PhD studentship (PD/BD/135503/2018). |
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Choroidal Vascular Impairment in Intermediate Age-Related Macular Degenerationintermediate AMDchorioretinal vasculatureoptical coherence tomographyOCTangiographyFunding: This work was supported by Fundação para a Ciência e Tecnologia project PTDC/MEDPAT/30385/2017 and iNOVA4Health-UIDB/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Educação e Ciência, Portugal, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement. A.C.F. was funded by FCT PhD studentship (PD/BD/135503/2018).Age-related macular degeneration (AMD) is a multifactorial disease, whose complete pathogenesis is still unclear. Local hemodynamics may play a crucial role in its manifestation and progression. To evaluate choroidal and retinal vascular parameters, a total of 134 eyes were analyzed, 100 with intermediate AMD and 34 age matched healthy controls. 131 eyes of 104 patients were eligible for complete image assessment and 3 eyes were excluded for insufficient image quality: Group 1: intermediate AMD ( n = 97) and Group 2: healthy controls ( n = 34). Spectral domain optic coherence tomography (SD-OCT) with enhanced depth imaging (EDI) and optic coherence tomography angiography (OCT-A) were acquired using Spectralis (Heidelberg Engineering). Choroid and retinal capillary plexus were evaluated and image binarization was used to obtain quantitative data. Mean age was 77.67 years old (YO) and 67.2% were women. Total subfoveal choroidal area and luminal area were significantly reduced in Group 1 compared with Group 2 (0.88 mm 2 and 0.40 mm 2 vs. 1.24 mm 2 and 0.55 mm 2, respectively) ( p < 0.05). Regarding choriocapillary flow density, AMD eyes recorded reduced values (34.83%) compared with controls (36.25%) ( p < 0.05). Chorioretinal vasculature is impaired in intermediate AMD patients and vascular parameters could be attractive new prognostic biomarkers. Future therapeutic approaches may target this vascular dysfunction and delay disease progression.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFlores, RitaCarneiro, ÂngelaNeri, GuilhermeFradinho, Ana CQuenderra, BrunoBarata, Maria JoãoTenreiro, SandraSeabra, Miguel C2022-06-28T22:27:53Z2022-05-222022-05-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/140995eng2075-4418PURE: 45002711https://doi.org/10.3390/diagnostics12051290info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:18:15Zoai:run.unl.pt:10362/140995Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:49:52.946456Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| title |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| spellingShingle |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration Flores, Rita intermediate AMD chorioretinal vasculature optical coherence tomography OCTangiography |
| title_short |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| title_full |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| title_fullStr |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| title_full_unstemmed |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| title_sort |
Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration |
| author |
Flores, Rita |
| author_facet |
Flores, Rita Carneiro, Ângela Neri, Guilherme Fradinho, Ana C Quenderra, Bruno Barata, Maria João Tenreiro, Sandra Seabra, Miguel C |
| author_role |
author |
| author2 |
Carneiro, Ângela Neri, Guilherme Fradinho, Ana C Quenderra, Bruno Barata, Maria João Tenreiro, Sandra Seabra, Miguel C |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Flores, Rita Carneiro, Ângela Neri, Guilherme Fradinho, Ana C Quenderra, Bruno Barata, Maria João Tenreiro, Sandra Seabra, Miguel C |
| dc.subject.por.fl_str_mv |
intermediate AMD chorioretinal vasculature optical coherence tomography OCTangiography |
| topic |
intermediate AMD chorioretinal vasculature optical coherence tomography OCTangiography |
| description |
Funding: This work was supported by Fundação para a Ciência e Tecnologia project PTDC/MEDPAT/30385/2017 and iNOVA4Health-UIDB/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Educação e Ciência, Portugal, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement. A.C.F. was funded by FCT PhD studentship (PD/BD/135503/2018). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-06-28T22:27:53Z 2022-05-22 2022-05-22T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/140995 |
| url |
http://hdl.handle.net/10362/140995 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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2075-4418 PURE: 45002711 https://doi.org/10.3390/diagnostics12051290 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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