Iron gene expression profile in atherogenic Mox macrophages

Detalhes bibliográficos
Autor(a) principal: Marques, L.
Data de Publicação: 2016
Outros Autores: Negre-Salvayre, A., Costa, L., Canonne-Hergaux, F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3825
Resumo: The role of macrophage iron in the physiopathology of atherosclerosis is an open question that needs to be clarified. In atherosclerotic lesions, recruited macrophages are submitted to cytokines and oxidized lipids which influence their phenotype. An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described.
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spelling Iron gene expression profile in atherogenic Mox macrophagesAtherosclerosisIron MetabolismMacrophageMoxOxidized LDLProinflammatory StimuliDeterminantes Imunológicos em Doenças CrónicasThe role of macrophage iron in the physiopathology of atherosclerosis is an open question that needs to be clarified. In atherosclerotic lesions, recruited macrophages are submitted to cytokines and oxidized lipids which influence their phenotype. An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described.This work was supported by: Fundação para a Ciência e a Tecnologia, Portugal (grant number SFRH/BD/48671/2008 to LM); BioISI centre grant (Centre Reference: UID/MULTI/04046/2013) from FCT/MCTES/PIDDAC, Portugal; Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal; INSERM, France; Agence Nationale de la Recherche, France (grant number ANR 2010 MIDI 004 02).ElsevierRepositório Científico do Instituto Nacional de SaúdeMarques, L.Negre-Salvayre, A.Costa, L.Canonne-Hergaux, F.2020-04-01T00:30:11Z2016-03-102016-03-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3825engBiochim Biophys Acta. 2016 Jun;1862(6):1137-46. doi: 10.1016/j.bbadis.2016.03.004. Epub 2016 Mar 10.0006-3002)doi.org/10.1016/j.bbadis.2016.03.004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:59Zoai:repositorio.insa.pt:10400.18/3825Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:37.627546Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Iron gene expression profile in atherogenic Mox macrophages
title Iron gene expression profile in atherogenic Mox macrophages
spellingShingle Iron gene expression profile in atherogenic Mox macrophages
Marques, L.
Atherosclerosis
Iron Metabolism
Macrophage
Mox
Oxidized LDL
Proinflammatory Stimuli
Determinantes Imunológicos em Doenças Crónicas
title_short Iron gene expression profile in atherogenic Mox macrophages
title_full Iron gene expression profile in atherogenic Mox macrophages
title_fullStr Iron gene expression profile in atherogenic Mox macrophages
title_full_unstemmed Iron gene expression profile in atherogenic Mox macrophages
title_sort Iron gene expression profile in atherogenic Mox macrophages
author Marques, L.
author_facet Marques, L.
Negre-Salvayre, A.
Costa, L.
Canonne-Hergaux, F.
author_role author
author2 Negre-Salvayre, A.
Costa, L.
Canonne-Hergaux, F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Marques, L.
Negre-Salvayre, A.
Costa, L.
Canonne-Hergaux, F.
dc.subject.por.fl_str_mv Atherosclerosis
Iron Metabolism
Macrophage
Mox
Oxidized LDL
Proinflammatory Stimuli
Determinantes Imunológicos em Doenças Crónicas
topic Atherosclerosis
Iron Metabolism
Macrophage
Mox
Oxidized LDL
Proinflammatory Stimuli
Determinantes Imunológicos em Doenças Crónicas
description The role of macrophage iron in the physiopathology of atherosclerosis is an open question that needs to be clarified. In atherosclerotic lesions, recruited macrophages are submitted to cytokines and oxidized lipids which influence their phenotype. An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-10
2016-03-10T00:00:00Z
2020-04-01T00:30:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3825
url http://hdl.handle.net/10400.18/3825
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochim Biophys Acta. 2016 Jun;1862(6):1137-46. doi: 10.1016/j.bbadis.2016.03.004. Epub 2016 Mar 10.
0006-3002)
doi.org/10.1016/j.bbadis.2016.03.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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