Iron gene expression profile in atherogenic Mox macrophages
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/3825 |
Resumo: | The role of macrophage iron in the physiopathology of atherosclerosis is an open question that needs to be clarified. In atherosclerotic lesions, recruited macrophages are submitted to cytokines and oxidized lipids which influence their phenotype. An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described. |
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Iron gene expression profile in atherogenic Mox macrophagesAtherosclerosisIron MetabolismMacrophageMoxOxidized LDLProinflammatory StimuliDeterminantes Imunológicos em Doenças CrónicasThe role of macrophage iron in the physiopathology of atherosclerosis is an open question that needs to be clarified. In atherosclerotic lesions, recruited macrophages are submitted to cytokines and oxidized lipids which influence their phenotype. An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described.This work was supported by: Fundação para a Ciência e a Tecnologia, Portugal (grant number SFRH/BD/48671/2008 to LM); BioISI centre grant (Centre Reference: UID/MULTI/04046/2013) from FCT/MCTES/PIDDAC, Portugal; Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal; INSERM, France; Agence Nationale de la Recherche, France (grant number ANR 2010 MIDI 004 02).ElsevierRepositório Científico do Instituto Nacional de SaúdeMarques, L.Negre-Salvayre, A.Costa, L.Canonne-Hergaux, F.2020-04-01T00:30:11Z2016-03-102016-03-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3825engBiochim Biophys Acta. 2016 Jun;1862(6):1137-46. doi: 10.1016/j.bbadis.2016.03.004. Epub 2016 Mar 10.0006-3002)doi.org/10.1016/j.bbadis.2016.03.004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:59Zoai:repositorio.insa.pt:10400.18/3825Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:37.627546Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Iron gene expression profile in atherogenic Mox macrophages |
title |
Iron gene expression profile in atherogenic Mox macrophages |
spellingShingle |
Iron gene expression profile in atherogenic Mox macrophages Marques, L. Atherosclerosis Iron Metabolism Macrophage Mox Oxidized LDL Proinflammatory Stimuli Determinantes Imunológicos em Doenças Crónicas |
title_short |
Iron gene expression profile in atherogenic Mox macrophages |
title_full |
Iron gene expression profile in atherogenic Mox macrophages |
title_fullStr |
Iron gene expression profile in atherogenic Mox macrophages |
title_full_unstemmed |
Iron gene expression profile in atherogenic Mox macrophages |
title_sort |
Iron gene expression profile in atherogenic Mox macrophages |
author |
Marques, L. |
author_facet |
Marques, L. Negre-Salvayre, A. Costa, L. Canonne-Hergaux, F. |
author_role |
author |
author2 |
Negre-Salvayre, A. Costa, L. Canonne-Hergaux, F. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Marques, L. Negre-Salvayre, A. Costa, L. Canonne-Hergaux, F. |
dc.subject.por.fl_str_mv |
Atherosclerosis Iron Metabolism Macrophage Mox Oxidized LDL Proinflammatory Stimuli Determinantes Imunológicos em Doenças Crónicas |
topic |
Atherosclerosis Iron Metabolism Macrophage Mox Oxidized LDL Proinflammatory Stimuli Determinantes Imunológicos em Doenças Crónicas |
description |
The role of macrophage iron in the physiopathology of atherosclerosis is an open question that needs to be clarified. In atherosclerotic lesions, recruited macrophages are submitted to cytokines and oxidized lipids which influence their phenotype. An important phenotypic population driven by oxidized phospholipids is the Mox macrophages which present unique biological properties but their iron phenotype is not well described. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-10 2016-03-10T00:00:00Z 2020-04-01T00:30:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/3825 |
url |
http://hdl.handle.net/10400.18/3825 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biochim Biophys Acta. 2016 Jun;1862(6):1137-46. doi: 10.1016/j.bbadis.2016.03.004. Epub 2016 Mar 10. 0006-3002) doi.org/10.1016/j.bbadis.2016.03.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132123678900224 |