Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies

Detalhes bibliográficos
Autor(a) principal: Jorge, Ludmilla R.
Data de Publicação: 2020
Outros Autores: Harada, Liliam K., Silva, Erica C., Campos, Welida F., Moreli, Fernanda C., Shimamoto, Gustavo, Pereira, Jorge F. B., Oliveira, José M, Tubino, Matthieu, Vila, Marta M. D. C., Balcão, Victor M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106121
https://doi.org/10.3389/fphar.2020.00243
Resumo: In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.
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spelling Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studieshuman insulinionic liquidscholine geranatecholine oleatetransdermal permeationchemical and biological characterizationIn this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.Frontiers Media S.A.2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106121http://hdl.handle.net/10316/106121https://doi.org/10.3389/fphar.2020.00243eng1663-9812Jorge, Ludmilla R.Harada, Liliam K.Silva, Erica C.Campos, Welida F.Moreli, Fernanda C.Shimamoto, GustavoPereira, Jorge F. B.Oliveira, José MTubino, MatthieuVila, Marta M. D. C.Balcão, Victor M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-21T21:35:03Zoai:estudogeral.uc.pt:10316/106121Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:35.183480Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
title Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
spellingShingle Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
Jorge, Ludmilla R.
human insulin
ionic liquids
choline geranate
choline oleate
transdermal permeation
chemical and biological characterization
title_short Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
title_full Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
title_fullStr Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
title_full_unstemmed Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
title_sort Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
author Jorge, Ludmilla R.
author_facet Jorge, Ludmilla R.
Harada, Liliam K.
Silva, Erica C.
Campos, Welida F.
Moreli, Fernanda C.
Shimamoto, Gustavo
Pereira, Jorge F. B.
Oliveira, José M
Tubino, Matthieu
Vila, Marta M. D. C.
Balcão, Victor M.
author_role author
author2 Harada, Liliam K.
Silva, Erica C.
Campos, Welida F.
Moreli, Fernanda C.
Shimamoto, Gustavo
Pereira, Jorge F. B.
Oliveira, José M
Tubino, Matthieu
Vila, Marta M. D. C.
Balcão, Victor M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jorge, Ludmilla R.
Harada, Liliam K.
Silva, Erica C.
Campos, Welida F.
Moreli, Fernanda C.
Shimamoto, Gustavo
Pereira, Jorge F. B.
Oliveira, José M
Tubino, Matthieu
Vila, Marta M. D. C.
Balcão, Victor M.
dc.subject.por.fl_str_mv human insulin
ionic liquids
choline geranate
choline oleate
transdermal permeation
chemical and biological characterization
topic human insulin
ionic liquids
choline geranate
choline oleate
transdermal permeation
chemical and biological characterization
description In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106121
http://hdl.handle.net/10316/106121
https://doi.org/10.3389/fphar.2020.00243
url http://hdl.handle.net/10316/106121
https://doi.org/10.3389/fphar.2020.00243
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1663-9812
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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