Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106121 https://doi.org/10.3389/fphar.2020.00243 |
Resumo: | In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin. |
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Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studieshuman insulinionic liquidscholine geranatecholine oleatetransdermal permeationchemical and biological characterizationIn this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.Frontiers Media S.A.2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106121http://hdl.handle.net/10316/106121https://doi.org/10.3389/fphar.2020.00243eng1663-9812Jorge, Ludmilla R.Harada, Liliam K.Silva, Erica C.Campos, Welida F.Moreli, Fernanda C.Shimamoto, GustavoPereira, Jorge F. B.Oliveira, José MTubino, MatthieuVila, Marta M. D. C.Balcão, Victor M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-21T21:35:03Zoai:estudogeral.uc.pt:10316/106121Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:35.183480Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
title |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
spellingShingle |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies Jorge, Ludmilla R. human insulin ionic liquids choline geranate choline oleate transdermal permeation chemical and biological characterization |
title_short |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
title_full |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
title_fullStr |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
title_full_unstemmed |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
title_sort |
Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies |
author |
Jorge, Ludmilla R. |
author_facet |
Jorge, Ludmilla R. Harada, Liliam K. Silva, Erica C. Campos, Welida F. Moreli, Fernanda C. Shimamoto, Gustavo Pereira, Jorge F. B. Oliveira, José M Tubino, Matthieu Vila, Marta M. D. C. Balcão, Victor M. |
author_role |
author |
author2 |
Harada, Liliam K. Silva, Erica C. Campos, Welida F. Moreli, Fernanda C. Shimamoto, Gustavo Pereira, Jorge F. B. Oliveira, José M Tubino, Matthieu Vila, Marta M. D. C. Balcão, Victor M. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jorge, Ludmilla R. Harada, Liliam K. Silva, Erica C. Campos, Welida F. Moreli, Fernanda C. Shimamoto, Gustavo Pereira, Jorge F. B. Oliveira, José M Tubino, Matthieu Vila, Marta M. D. C. Balcão, Victor M. |
dc.subject.por.fl_str_mv |
human insulin ionic liquids choline geranate choline oleate transdermal permeation chemical and biological characterization |
topic |
human insulin ionic liquids choline geranate choline oleate transdermal permeation chemical and biological characterization |
description |
In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106121 http://hdl.handle.net/10316/106121 https://doi.org/10.3389/fphar.2020.00243 |
url |
http://hdl.handle.net/10316/106121 https://doi.org/10.3389/fphar.2020.00243 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1663-9812 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134114958278656 |